Chondroitin complex

Chondroitin complex is a combined medicine that is prescribed for the healing of cartilage tissues.

[1], [2], [3]

Indications Chondroitin complex

It is used in the treatment of diseases affecting the function of joints with the spine - such as arthropathy, osteoarthritis, spondylosis and osteochondrosis of the intervertebral type. It is also possible to prescribe a remedy to restore bones after a fracture.

[4], [5]

Release form

Release of the medication is realized in capsules contained in flacon.

[6], [7], [8], [9], [10]

Pharmacodynamics

The effect of the drug is provided by the action of its constituent elements.

Sodium chondroitin sulfate is a high-molecular-type mucopolysaccharide that is an important participant in the processes of building cartilage tissues. It weakens the effect of enzymes that destroy cartilage in the joint region, and also promotes their healing. Due to this, the articular function is normalized. The drug slows the development of inflammation in the initial stages, and also inhibits the degeneration of cartilage tissue.

During the treatment of osteoarthritis in the knee or hip joint area, this element helps to reduce pain and reduces the need for NSAIDs.

Glucosamine hydrochloride is a chondroprotective element. It affects the processes of biosynthesis of hyaluronan with proteoglycans, and besides it reduces the deficiency of glycosamin.

At the same time, during the binding of chondroitinsulfuric acid, this component activates sulfur fixation. It also selectively affects cartilage within the joints, slows the formation of enzymes that destroy cartilage tissue, and superoxide radicals. In addition, it prevents the disruption of glycosaminoglycan biosynthesis processes induced by NSAIDs and interferes with the destructive effect of chondrocytes with SCS.

[11], [12]

Pharmacokinetics

With a single use of capsules in standard portions, the peak values of chondroitin within the plasma are noted after 3-4 hours. Excretion of the substance occurs after 24 hours - through the kidneys. Bioavailability indicators are 13%.

Glucosamine hydrochloride is absorbed through the intestine. Approximately 25% of the element penetrates the cartilage tissues and articular synovial membranes. Some of the substance is biotransformed inside the liver, resulting in the formation of water, urea and carbon dioxide.

[13], [14], [15], [16], [17],

Dosing and administration

Drink medication is necessary orally - the capsules are swallowed whole, without pre-chewing, 30 minutes before eating. Take the medicine you drink with plain water. The duration of the therapy cycle and the size of the dosage portions are selected by the physician, which takes into account the degree of severity of the pathology, and its nature.

Usually an adult and a teenager over 15 years of age are prescribed a daily capsule intake of 1 unit twice a day. After 3 weeks of such a course, it is allowed to switch to a single capsule intake per day.

Often, this treatment lasts 2 months, but to get a stable drug effect, you need to use the drug for at least 0.5 years.

During treatment it is recommended to stop using alcohol and reduce the amount of sugar in the diet.

[21], [22], [23], [24]

Use Chondroitin complex during pregnancy

Prescribe chondroitin complex to pregnant women - it is forbidden.

Contraindications

The main contraindications:

• the presence of hypersensitivity to drugs;
• tendency to bleeding;
• the period of breastfeeding;
• diabetes;
• thrombophlebitis;
• problems with the work of the liver or kidneys, having a pronounced form;
• phenylketonuria.

[18], [19], [20]

Side effects Chondroitin complex

The use of medication can trigger the appearance of such side effects:

• disorders in the work of the digestive tract: diarrhea, pain in the epigastrium, nausea, constipation, vomiting and bloating;
• allergy symptoms: the appearance of hives, swelling, rashes on the epidermis, itching, dermatitis or erythema;
• disorders of the central nervous system: insomnia, increased fatigue, a feeling of drowsiness or general weakness, dizziness, and headaches.

In case of appearance of negative symptoms, you need to stop taking capsules and consult a doctor.

Overdose

There is no evidence of Chondroitin complex poisoning. It is believed that in case of an overdose, an increase in the intensity of the negative symptoms can be expected.

Treatment involves symptomatic procedures. Also in such cases it is recommended to consult your doctor.

[25], [26],

Interactions with other drugs

Combination of the drug with tetracyclines can cause increased absorption in the gastrointestinal tract. But when combined with lemomitsetinom or semi-artificial penicillin reverse reaction is observed - the intensity of absorption is weakened.

The medication reduces the body's need for using GCS, analgesic drugs and NSAIDs.

The effectiveness of the treatment is increased when meals containing retinol and vitamin C are included in the food ration, and in addition manganese salts, selenium, zinc with copper and magnesium.

[27], [28], [29]

Storage conditions

Chondroitin complex is required to be kept out of the reach of children. Temperature indicators - no more than 25ºС.

[30], [31], [32], [33], [34]

Shelf life

Chondroitin complex is allowed to be used within 24 months from the date of manufacture of the drug.

[35], [36]

Application for children

The use of the drug in children is not allowed.

[37], [38], [39]

Reviews

The chondroitin complex usually receives positive reviews. Accepted patients noted the high therapeutic effectiveness and convenience of the dosage form.

Of the minuses, the presence of negative signs (mainly in the work of the digestive tract, but it rarely happens) is singled out, and besides this, the price of the medicine is quite high. There are also reviews, which indicate that in pharmacies this drug is difficult to find.