Umbrella

Omnadren is an androgenic drug that contains a mixture of testosterone esters.

Indications Omnidirectional

It is used in the treatment of such disorders in men:

• eunuchoidism;
• gipopituitarizm ;
• post-stroke syndrome;
• oligospermia;
• symptoms of men's menopause;
• infertility or impotence ;
• androgen deficiency (a similar condition is often observed in dwarfism, hypokorticism, or adiposogenital syndrome).

In women, medication is prescribed for the following disorders:

• osteoporosis, which is due to a deficiency of androgens;
• symptoms of breast cancer;
• ovarian carcinoma;
• Hyperestrogenism, against which there are dysfunctional bleeding from the uterus;
• uterine myoma or endometriosis;
• signs of PMS;
• manifestations observed during menopause;
• as virilization of the external genitalia in hermaphroditism.

[1]

Release form

The release is made in the form of an oily liquid for injection, in ampoules, having a capacity of 1 ml. Inside the box there are 5 such ampoules.

[2], [3], [4], [5]

Pharmacodynamics

Testosterone is a direct participant in the processes of formation of seminal vesicles with testicles and the prostate, and at the same time participates in the development of sexual characteristics of secondary and tertiary character. In addition, this hormone affects the formation of a general bodily constitution and human sexual behavior. The element helps to strengthen sexual desire and potency, stimulates the activation of spermatogenesis processes, and also reduces the severity of menopausal manifestations in men.

Testosterone is an antagonist of the female sex hormone estrogen. Its influence leads to a slowing of the gonadotropic activity of the pituitary gland and the suppression of the operation of the mammary glands. A person undergoing treatment with this medication may have signs of masculinization.

The drug acts as an anabolic: it increases the rate of protein binding, helps to potentiate calcium retention inside bone tissues, increases hemoglobin levels inside the blood and muscle mass, and in addition activates the renal production of erythropoietin.

The introduction of exogenous testosterone to a healthy man results in suppression of the production of natural, endogenous testosterone. This is due to a decrease in LH release. The use of large portions of the drug leads to suppression of spermatogenesis, because it affects the reverse retardation of FSH release processes.

During therapy with testosterone in men who have functional pituitary insufficiency, potentiation of signs of hypogonadism is observed. But if impotence is not associated with hypogonadism, but with other factors, then using Omnadrena can not solve the problem.

[6], [7], [8], [9], [10],

Pharmacokinetics

Testosterone esters contained in the drug have a different rate of absorption and excretion, which causes a rapid drug exposure and a long-lasting effect (approximately 1 month) with 1-fold use. For example, the effect of testosterone propionate develops already during the 1st day after use, and isocapro- nate with testosterone phenylpropionate begins to act only after 24 hours from the time of use.

The caprolate of testosterone has an effect on that time interval, when the effect of phenylpropionate and isocaproton of testosterone is no longer recorded.

Protein synthesis of the drug inside the plasma is 98%. Exchange processes occur inside the liver; 17-ketosteroids are formed, which are further synthesized with sulfuric or glucuronic acid. After that, they are excreted in the urine.

Approximately 90% of the drug is excreted by the kidneys in the form of a metabolic product, and another 6% by the intestine, in an unchanged state.

The testosterone half-life is within 10-100 minutes.

[11], [12], [13]

Dosing and administration

The drug is used in a portion of 1 ml of substance administered 1-fold during the 28-day period. The procedure is performed intramuscularly - the drug is injected deep inside the gluteus muscle. The size of the portion is chosen by the attending doctor, taking into account the prescribed indications and how the patient's organism reacts to the use of the medication.

In the case of treatment of the primary form of hypogonadism in men, the drug is administered in / m in a 1-time fashion, with an interval of 7, 14 or 21 days. At the same time, the frequency of the procedure is determined by the degree of manifestation of insufficiency of the function of the genital glands of the patient.

In the case of the male climax, Omnadren is applied 1-fold for 14 days. Further, when the effect of drug use becomes noticeable, it is required to transfer the patient to the use of the drug 1-fold for 21 days.

During the treatment of infertility, a man requires the introduction of 2 ml of the drug 1-fold for 2 weeks. When there is pain during the treatment in the penis during erection, the treatment course should be canceled.

During a woman's menopause, the medication is used in a 1 ml dose, with 1x application for 2 or 3 weeks.

With oncology affecting the breast or ovaries, the solution is used in a dosage of 1-2 ml, 1 time per 1 or 2 weeks. This cycle lasts a fairly long time.

[22], [23]

Use Omnidirectional during pregnancy

Omnadren can not be given to nursing or pregnant women. If it is necessary to carry out therapy during lactation, breastfeeding should be abandoned for this period.

Contraindications

The main contraindications:

• gynecomastia;
• the presence of a suspicion of prostate cancer or an already diagnosed disease;
• asthenia;
• hypercalciuria or calcemia;
• deficiency of the kidneys, heart or liver;
• application for elderly men;
• the presence of intolerance with respect to the drug.

[14], [15], [16]

Side effects Omnidirectional

The use of medication can cause some side effects:

• disorders of the endocrine function: in women, there may be the appearance of hirsutism, dysmenorrhea or masculinization, and in addition a slowdown in the processes of gonadotropin release. Men may have a disorder of spermatogenesis, but also the occurrence of gynecomastia, oligospermia, or priapism. In case of use in adolescent boys, over-active puberty is possible;
• problems with the functioning of the reproductive system: a disorder of libido;
• lesions affecting the epidermis: alopecia in the male type and the appearance of acne;
• disorders of digestive activity: the emergence of liver tumors or purpura, nausea, and in addition, problems in the work of the liver and cholestatic form of jaundice;
• disturbances in the processes of blood uptake: inhibition of the activity of a variety of factors of blood circulation inside the plasma, and in addition, the development of bleeding in persons using drugs that have an anti-shaking effect;
• problems related to the operation of the PNS or CNS: headaches, a sense of fear, paresthesia;
• disorders of metabolic processes: an increase in the values of cholesterol inside the blood plasma.

Local symptoms and pain can also develop on the areas of substance administration.

[17], [18], [19], [20], [21]

Interactions with other drugs

When used together with the drug anticoagulants for ingestion, you should regularly and carefully monitor the level of blood loss.

In diabetics who use androgenic medications, with the introduction of Omnadrena blood sugar can decrease, and in addition there may be a need for the use of insulin.

The use of a drug in combination with SCS or ACTH increases the likelihood of peripheral edemas - for example, in people with hepatic pathologies or lesions affecting CAS.

The effects of testosterone may be weakened by combining the substance with medicaments that stimulate the induction of microsomal hepatic enzymes.

[24], [25], [26]

Storage conditions

Omnadren is required to be kept in a place protected from sunlight, at temperatures ranging from 15-25 ° C.

When a precipitate in the form of flakes appears in the solution, it is required to place the ampoule with it for a short period of time in ordinary water having a temperature of 37 ° C.

[27]

Shelf life

Omnadren is allowed to be used within 36 months from the date of manufacture of the medicinal product.

Application for children

The drug is not used for therapy in boys who are prepubertal.

[28], [29]

Analogues

Analogues of the drug are such medicines as Testanat with Androgel and Nebido, and in addition Sustanon-250, Andriol TK, Tetrasterone, Methyltestosterone and Testosterone propionate.

[30]

Reviews

Omnadren receives quite a variety of reviews. For example, some of the patients who used the medication talk about the development of certain side effects caused by the characteristics of the medication.

Among the observations - long-term therapy causes disorders of the liver function, fluid retention and the appearance of pronounced acne on the epidermis. Along with this, because of the wide availability of the drug, it is often injected in too large portions - in an attempt to build muscle mass. Excessive excess of the allowable portion leads to the appearance of negative symptoms.