Candide

Candide has a local antimycotic and antibacterial effect, and besides it has a trichomonasidic and antiprotozoal effect.

Indications Candida

It is used for the treatment of such signs or diseases:

• lichen, having a multicolored or pearly shape;
• mycoses that occur in the skin folds or on the feet;
• erythrazia;
• candidiasis of superficial nature, caused by the activity of mold, yeast and other fungi, dermatophytes and other microbial pathogens that are sensitive to clotrimazole;
• complicated by the development of pyoderma secondary character of mycosis;
• candidal form of vulvitis or balanitis;
• epidermal candidiasis;
• paronychia candida;
• Candidiasis in the area of the external genitalia or anus;
• diaper dermatitis of fungal origin.

A solution for the oral cavity is used in the treatment of stomatitis of Candida etiology.

Vaginal tablets are prescribed for the treatment of infections and superinfections in the genital area that are caused by the activity of bacteria that are sensitive to clotrimazole.

In addition, Candida can be used as a sanation in the field of the birth canal in the process of preparing for childbirth.

[1], [2], [3]

Release form

The release of the medication is realized in the form of a 2% gel, 1% cream for external treatment (in a tube of 20 g), 1% powder for external use (in plastic bottle with a capacity of 30 g), 1% solution for local processing (in a flacon with a volume of 15 g), and besides this in vaginal suppositories.

[4], [5], [6], [7], [8], [9], [10], [11], [12]

Pharmacodynamics

The antimycotic effect of clotrimazole (an active element of the drug, which is an imidazole derivative) develops by destroying the processes of ergosterol binding, which is contained in the cell walls of the fungus. As a result, the degree of permeability of fungal walls varies, which entails cell lysis.

The interaction of fungicidal parameters of drugs with mitochondrial as well as peroxidase enzymes is observed, which provokes an increase in the values of hydrogen peroxide to a toxic level. This causes the destruction of fungal cells.

The drug has a fungicidal and fungistatic effect on dermatomycetes (red trichophyton, interdigital trichophyton, flaky epidermophyton and fluffy microsporium), yeast-like and mold fungi (from the genus Candida, Candida glabrate, Pityrosporum orbiculare and the genus Rhodotorol).

Together with this, clotrimazole has activity against the exciter bacterium in a variety of forms.

Candida effectively affects gram-negative and-positive microbes. At high concentrations, the drug shows activity against vaginal trichomonas.

[13], [14], [15], [16], [17]

Pharmacokinetics

Through the epidermis and mucosal preparation is absorbed poorly, because of which local use of drugs does not cause systemic influence. After external application within the epidermis, a greater concentration of the drug component is noted than inside the dermis and subcutaneous layers.

After intravaginal application, the absorption of the drug is 3-10% of the administered dosage. During 2-3 days, low values of drugs are observed inside the blood; inside the vaginal secretion the level of medication is quite high.

The processes of clotrimazole metabolism are carried out inside the liver.

[18], [19], [20], [21],

Dosing and administration

Method of using the cream.

Apply the cream should be external, previously washing and drying those areas on the epidermis, where the lesion is located. Clean the skin with soap, which has neutral pH. Apply a thin layer of the drug, after which it is gently rubbed into the epidermis; to conduct such a procedure should be 2-3 times a day. The duration of the treatment cycle is determined by the doctor; the duration of this period depends on the degree of severity of pathology and localization of the lesion, and at the same time on the therapeutic effectiveness of drugs.

For the treatment of dermatomycosis, a minimum of 1 month course is required, and in the case of a pungent form, depriving of the use of the cream is necessary within 1-3 weeks. Patients with fungal lesions affecting the epidermis on the legs, it is required to constantly use the cream in a period of at least 14 days after the disappearance of signs of the disease.

The use of medication depends on the characteristics of the course of the pathology, and on the degree of its intensity. Usually the cream is rubbed into the affected area 2-3 times per day. It is also recommended to use it for 3-4 weeks in addition to completely eliminate the possibility of relapses.

Method of using a medicamental solution.

The solution is usually used for extensive lesions of the epidermis, but also for diseases developing in the scalp. When administering drops, the instructions and recommendations of the doctor should be strictly observed.

In case of treatment of lesions inside the mouth, moisten the cotton swab in a solution (10-20 drops of substance) and treat affected areas with it; this procedure is recommended to be performed 3-4 times a day, doing the processing as carefully as possible. The drug is used until the complete disappearance of clinical signs of the disease.

Scheme of the use of powder.

The powder should be applied externally, to the affected areas of the epidermis, 3-4 times a day. It is important that the treatment is regular - the procedure should be carried out continuously.

The duration of the therapeutic cycle is determined by the severity of the pathology and the location of the lesion. To completely cure the disease, it is sometimes necessary to continue therapy after eliminating the manifestations.

Usually therapy lasts 1 month. People with impaired otrebus character should use the medication within 1-3 weeks, and people with erythrasma need to continue therapy during the 0.5-1 month period.

Use of vaginal suppositories.

It is necessary to administer the tablets intravaginally. The procedure is carried out from the position of lying, and you also need to bend your legs. Use the suppository should be 1-fold a day, introducing them in the evening, before going to bed.

For sanation before childbirth, you must enter 1-well drug pill (0.5 g of therapeutic substance).

[29], [30], [31], [32], [33]

Use Candida during pregnancy

There is no clinically reliable information that the local use of Candida in pregnancy, as well as breastfeeding, adversely affects the body of a woman, a fetus or an infant. But to determine the appropriateness of using drugs in the 2nd and 3rd trimesters, and in addition to breastfeeding should only the doctor.

It is forbidden to treat the breast with breast milk.

Contraindications

The main contraindications:

• the presence of intolerance against clotrimazole or other components of the drug;
• use in menstruation.

[22], [23], [24]

Side effects Candida

The use of medication can lead to the emergence of certain side-effects:

• itching, urticaria and a sensation of tingling or burning in the area of cream treatment;
• puffiness, irritation and peeling of the epidermis, as well as blisters and erythema.

If any of the above symptoms occur, you must cancel the use of the ointment.

After intravaginal administration of the drug, local irritation occasionally arises, often disappearing on its own without stopping therapy. In addition, with this method of using Candida, the following negative symptoms may occur:

• burning sensation and itching;
• vaginal discharge or swelling of the vaginal mucosa;
• headache;
• increased frequency of urination and the development of interstitial cystitis;
• the appearance of pain during sexual contact;
• a burning sensation in the genital area of a man.

[25], [26], [27], [28]

Overdose

The use of cream in large portions does not cause the appearance of negative symptoms and the development of life-threatening conditions.

When you take the medicine, you may have vomiting, signs of allergy, nausea, development of anorexia, gastralgia or pollakiuria. Occasionally there is a feeling of drowsiness or hallucinations.

The medicine does not have an antidote. When oral use is necessary to give the patient activated charcoal, and in addition to carry out symptomatic activities.

[34], [35]

Interactions with other drugs

The effect of clotrimazole is weakened when combined with natamycin, nystatin, and amphotericin B. Therefore, Candide is not recommended for use with the above drugs.

There is no data on the development of adverse effects of other drugs when the drug is combined with them. This is due to the fact that clotrimazole has weak resorption properties.

[36], [37], [38], [39], [40]

Storage conditions

Candide is required to be kept out of the reach of small children. The temperature values are within the limits of 2-25 ° C.

[41], [42], [43], [44]

Shelf life

Candida in the form of a cream can be applied within 4 years from the moment of release of a medicinal product. The therapeutic solution has a shelf life of 36 months.

[45], [46]

Application for children

The solution is used to treat stomatitis in a child. You need to use it, strictly observing the instructions, and as directed by the doctor. In addition, it is prescribed for treatment in young children of certain fungal diseases - for example, thrush (appoint the drug in these cases, it can only doctor).

Newborns with candidiasis can also be prescribed a solution of the drug. The procedure of therapy is performed after breast-feeding. It is necessary to moisten in a solution (3-4 drops) a cotton swab or a stick, and then gently treat them affected by the disease areas inside the mouth. This procedure should be carried out 3 times a day. Already after the lapse of 2-3 days, there should be noticeable signs of improvement.

[47], [48]

Analogues

Analogues of the drug are drugs Imidil, Antifungol, Kandibene, Imidil cream, and besides Amicon with Clotrimazole, Kandizol with Kanestenom and Candid-B6.

[49], [50], [51], [52]

Reviews

Candide receives mostly positive comments from patients. Many of them note the high efficiency of the cream in the treatment of disorders caused by pathologies of fungal origin.

The solution is often used for therapy in children, because drops are more convenient to use, and also from the first procedure weaken the negative signs of disease.

Reviews of adults also contain information that the use of a gel or cream has allowed them to completely cure diseases of the fungal etiology and eliminate all negative symptoms. This leads to the conclusion that Candide in all therapeutic forms has high drug efficacy.