Revmoxicam

Revmoxicam belongs to the category of elective NSAIDs. The active ingredient is meloxicam.

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Indications of the revmoxicam

It is used to eliminate pain symptoms in people with diseases that affect ODA, and have a degenerative-inflammatory form.

Used for osteoarthritis and arthrosis. In addition, it is used in the combined treatment of rheumatoid arthritis and Bekhterev's disease.

Release form

The release of the drug is realized in tablet form (volume 7.5 or 15 mg), and in addition in injectable liquid and candles.

Tablets are distributed on blister plates, in an amount of 10 pieces. Inside the box there are 1-2 plates.

Rectal suppositories are packed in 5 pieces inside the blister, on the first blister inside the pack.

Injection liquid - in ampoules with a capacity of 1.5 mg. Inside the box there are 5 such ampoules.

Pharmacodynamics

The drug has a strong antipyretic, anti-inflammatory and analgesic activity. The effect of drugs is due to the fact that its active element is able to suppress the function of COX-2. Because of this, there is a decrease in the binding of pro-inflammatory cytokines acting as mediators of inflammatory processes. There is almost no effect on the activity of COX-1. Also, suppression of the binding of cytoprotective GH and thromboxane is not registered.

The use of medicines relieves pain and reduces the intensity of inflammation in diseases associated with the work of the ODA. At the same time, Revmoxicam does not affect the function of chondrocytes (for example, on the binding of an element of proteoglycan).

Pharmacokinetics

When ingested meloxicam is well absorbed inside the gastrointestinal tract, demonstrating a bioavailability index of 89%. The use of food does not affect the degree of absorption of drugs.

On the 3-5th day from the start of therapy, a stable indicator of meloxicam within the body is recorded (it does not matter what form of drugs to use). Synthesis with the intraplasma protein is 99%, and the meloxicam values within the synovia are 50% of its plasma indices.

The component undergoes a full metabolism inside the liver, transforming into inactive decay products. The half-life is 20 hours. Excretion of the substance is carried out by the intestines and kidneys (in approximately equal parts). Meloksikam can pass through the BBB and the histiocytic barrier.

Dosing and administration

Scheme of use of the tablet form.

The medicine is swallowed completely, without chewing, while washing with a lot of ordinary water. Use tablets with food to reduce the risk of negative symptoms in the gastrointestinal tract. The sizes of dosage portions are selected by the doctor individually. Usually people with osteoarthritis should take 7.5 mg per day. If there is a need, it is allowed to increase the dose in half - up to 15 mg.

People with rheumatoid arthritis or Bechterew's disease are required to take 15 mg of medicine per day. Further, upon achievement of the desired effect, it is necessary to use a maintenance dose of 7.5 mg / day.

Persons who are prone to develop negative symptoms are allowed to use the drug in dosages not exceeding 7.5 mg.

The mode of application of injections of medicinal substance.

To enter a medicine it is necessary in / m way, parenterally. The injection must be deep and be made into the gluteal region. The duration of the therapeutic cycle is selected by the doctor for each patient separately.

About a day, about 0.75-1.5 ml of a drug substance is usually administered. The injections are carried out once a day, at the same time they can be done no more than 5 days in a row. If necessary, further use the drug in its other drug forms. A day is allowed to enter no more than 15 mg of the substance.

Scheme of rectal suppository use.

The medication is administered rectally. Before starting the procedure, it is necessary to perform all the necessary hygiene measures. The length of the course and the size of the portion are chosen by the attending doctor. Usually, the administration of the first suppository is prescribed once a day. Use Revmoxicam allowed for a maximum of 7 consecutive days.

For gynecological procedures, suppositories are used exclusively with the appointment of a doctor, according to a scheme selected by a gynecologist.

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Use of the revmoxicam during pregnancy

It is forbidden to use a medicine (in any form) during pregnancy or lactation. It is important to completely exclude the possibility of pregnancy before starting therapy. During the treatment course, you should use reliable contraception. You can not use Revmoxicam at the conception planning stage.

Contraindications

The main contraindications:

• the presence of hypersensitivity relative to the elements of the drug;
• malabsorption of glucose-galactose, galactosemia, lactose intolerance (for tablets);
• ulcerative lesions developing inside the gastrointestinal tract;
• severe degree of heart failure;
• kidney or liver diseases, which have a severe character of leakage;
• rehabilitation after CABG surgery;
• The presence of a tendency to bleeding in a person or a recent bleeding of a cerebrovascular nature;
• pathologies that arise inside the rectum (for candles).

Intravenous administration of the drug is prohibited.

Caution is required to apply to people with bronchial asthma, liver cirrhosis, and in addition to depletion or dehydration of the body. Also, with caution should be used in the elderly or those who take anticoagulants, and in addition to people with diseases in the digestive system.

Side effects of the revmoxicam

The use of medication can cause the emergence of certain side-effects:

• disorders of the liver and digestive activity: problems with stool and digestive function, flatulence and nausea, abdominal pain and vomiting, and in addition eructations and increased activity of liver enzymes. Single gastritis, bleeding, ulcers and erosion in the gastrointestinal mucosa and stomatitis are noted;
• disturbances in the function of SSS and hematopoietic processes: swelling in the face or limbs, heart rhythm disorder, increased blood pressure, hyperemia, and also thrombocytopenia or leukopenia and anemia. Possible progression of heart failure and development of hypertension in people with diseases in the CCC;
• lesions affecting the work of the National Assembly: headaches, emotional instability, dizziness and day / night;
• disorders of urinary function: glomerular nephritis, renal insufficiency, which has an acute degree, tubulointerstitial nephritis and changes in blood urea and creatinine, and also nephrotic syndrome. Necrotic papillitis developed;
• affective sensory organs: ear noise, visual impairment, or conjunctivitis;
• allergy symptoms: hives, itching, photosensitivity, bronchial spasm, rashes or Stevens-Johnson syndrome. There may be angioedema or anaphylaxis;
• Other signs: the appearance of itching, irritation or burning in the anal area (when using candles).

If you have any negative symptoms after using any form of drugs, you must immediately cancel the treatment and consult your doctor.

Overdose

The use of medicament in large portions can trigger the occurrence of abdominal pains, nausea, feelings of drowsiness and vomiting, as well as a lethargic state. In addition, an overdose of the drug increases the risk of negative symptoms and increases the degree of their intensity.

A significant excess of the size of the allowable portion can lead to acute intoxication with meloxicam, because of which the patient has a disorder of hepatic and renal activity and increases blood pressure. A coma may also occur and a cardiac arrest may occur.

The medication does not have an antidote. To get rid of the disorders, you need to wash the stomach (if there was poisoning with tablets) or rectum (with intoxication with rectal suppositories). In addition, symptomatic activities are performed. If severe poisoning is noted, the affected person should be hospitalized.

Interactions with other drugs

Combined intake of the drug with other medications from the category of non-narcotic analgesics increases the risk of bleeding in the gastrointestinal tract and ulceration.

It is impossible to combine Revmoxicam with SSRIs, antiplatelet agents and anticoagulants, and in addition to heparin and thrombolytic agents.

Simultaneous use with diuretics in individuals with dehydration increases the likelihood of acute kidney failure. If this combination is necessary, renal activity should be monitored on a regular basis.

The drug weakens the effect of diuretics, vasodilators, medications that slow the activity of ACE, β-blockers and contraceptives placed inside the uterus.

The drug potentiates the hematotoxic effect of methotrexate, and in addition the negative effect of cyclosporin on the kidneys. Therefore, in such interactions, it is important to monitor kidney function and peripheral blood counts.

The drug increases the plasma values of lithium.

Combination of rheumoxicam with colestyramine reduces the half-life of the substance meloxicam.

The efficacy of oral antidiabetic drugs and insulin may change when combined with the drug. When prescribing a medication to people with diabetes, it is required to monitor the indicators of sugar and, if necessary, change the dosage of antidiabetics.

It is forbidden to mix injection liquid with other medicines inside one syringe.

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Storage conditions

Rheumoxicam in tablet form is required to be kept in a place closed from penetration of moisture and sunlight, with temperature indices ranging from 15-25 ° C.

The solution and suppository require temperature values within the range of 8-15 ° C.

Shelf life

Revmoxicam is allowed to be used for 24 months after the release of the drug.

Application for children

Medicine in any form can not be administered to children under 15 years of age.

Analogues

Analogues of the drug are Movalgin with Melox, Movalis and Meloxicam with Meloxicam-KV.

Reviews

Revmoxicam receives good reviews on the forums - it is believed that the drug in injections, tablets and suppositories copes well with the pain that appears due to osteoarthritis and other diseases of the ODA. But some people also report the presence of negative symptoms - feelings of drowsiness, increased values of blood pressure and abdominal pain.

There are also negative reviews from people who did not benefit from the medicine.

A lot of positive opinions about the drug are expressed in connection with the treatment of inflammations affecting the female urogenital system, but it must be taken into account that for the gynecological procedures of the suppository, only the doctor can prescribe Revmoxicam.