Venlaksor

Venlaxor is an antidepressant.

Indications of the venlaksora

It is used to prevent or eliminate depressions of various origins.

Release form

The release is produced in tablets with a volume of 37.5, and 75 mg - 10 pieces inside blister packs. The box contains 3 such plates.

Pharmacodynamics

The structure of Venlaxor does not allow to attribute it to some category of antidepressants. Antidepressant medicinal effect and mechanisms of LS influence are conditioned by the fact that the drug is capable of potentiating the transmission of nerve signals. The active element and its product of EFA metabolism are SSRIs, as well as IONS, and besides this substance, which slows down the processes of dopamine capture.

The therapeutic course with the use of medication (single or multiple use) helps to reduce β-adrenergic reactivity. The drug has no tropism for benzodiazepine, opioid, and also non-ciclidine endings.

[1], [2], [3], [4]

Pharmacokinetics

The drug is well absorbed inside the digestive tract. The maximum values of the substance within the blood plasma after a single use of 25-150 mg portions are 33-173 ng / ml. These indicators are kept in the body for 24 hours.

Inside the liver, metabolic processes are carried out. The product of drug metabolism is O-desmethylvenlafaxine (EFA) substance, which has medicinal properties similar to the active element.

The half-life of the active component not metabolized is 5 hours; a similar indicator for EFA is 11 hours. Synthesis of the drug with proteins - 30%.

Excretion is mainly done by the kidneys.

In the case of tablets taken with food, the duration of the peak period for drugs within the blood is prolonged for 30 minutes.

If the patient is ill with hepatic cirrhosis, the metabolic rate of the products inside the blood increases, and the process of excretion, on the contrary, becomes slower.

With a severe or moderate degree of kidney failure, Venlaksor's clearance and its elements decrease. The sex and age of patients does not affect the pharmacokinetic characteristics of the medication.

Dosing and administration

You need to take the tablets inside, along with the food, twice a day (1 tablet with a volume of 37.5 mg), in the morning, and also in the evening. The daily dosage is 75 mg. After 2-3 weeks, if the effect of taking drugs is not observed, it is possible to increase the daily dose to 150 mg.

During treatment of severe forms of depression, higher dosages are allowed - start therapy with a two-time intake of 75 mg LS. The daily portion in the presence of the need is allowed to increase by 75 mg at intervals of 3 days. You need to do this until the medication is achieved.

The maximum allowable size of a daily portion is 375 mg. When the desired result is achieved, the serving size must be gradually reduced to the minimum values. Supportive treatment, as well as the prevention of the development of negative symptoms with the intake of minimum allowable portions are allowed to be carried out for six months.

With insufficient kidneys at an easy stage, the size of the daily dosage should not be adjusted. With a moderate stage of the disease - you need to reduce the size of the dose by 25-50% (due to the fact that in this case the half-life will increase). Persons with a serious stage of pathology are forbidden to take medicine. For people who undergo hemodialysis procedures, they complete half the daily dosage at the end.

Very cautiously, Venlaxor should be taken by elderly people - in order to prevent a negative impact on renal activity. This group of patients receiving a minimum effective daily dose, and if the need for its increase, the patient should be monitored by the doctor.

To abolish the use of drugs should be gradually - for a minimum of 7-14 days, during which the dose rate gradually decreases. The end of the medication is determined by the size of the portions, the duration of the course and the individual needs of the patient.

Use of the venlaksora during pregnancy

Do not prescribe Venlaxor to pregnant women.

Contraindications

The main contraindications:

• the presence of high sensitivity with respect to the drug;
• persons under the age of 18;
• hepatic pathology and kidney failure in severe degree;
• the period of breastfeeding;
• simultaneous use with MAOI.

Caution is required in case of application in such cases:

• recent myocardial infarction;
• increased blood pressure;
• an unstable form of angina pectoris;
• present in the anamnesis manic conditions or convulsive syndrome;
• increased values of IOP;
• presence of tachycardia;
• the tendency of the skin surface to develop bleeding;
• reduced weight.

Side effects of the venlaksora

The development of adverse symptoms of the drug depends on the duration of its use and the size of consumed portions. Often the complications are manifested in the form of a feeling of weakness, nausea, increased fatigue, a decrease in appetite, dryness of the oral mucosa and vomiting; more rarely there is constipation.

In addition, there may be an increase in cholesterol levels within the blood, weight loss, tachycardia and an increase in blood pressure. More rarely there are disorders in the work of the NS: unusual dreams or insomnia, dizziness, stupor, or increased excitability, and besides paresthesia, yawning, increased muscle tone and tremor. Occasionally, manic symptoms and seizures of epilepsy are noted.

Sometimes the disorders affect the urogenital system: dysuric disorders develop, problems with ejaculation and erection, anorgasmia or menorrhagia, and in addition, delayed urination and weakening of libido.

There are also problems with the function of the sensory organs: the development of mydriasis, visual disorders, accommodation disorders or taste buds. Lesions of the skin surface: the appearance of polyiform erythema, hyperhidrosis, rashes and hyperemia. Violations affecting the hematopoietic system: the development of thrombocytopenia, and in addition to this hemorrhage in the area of the skin or mucous membranes.

There are also anaphylactic signs.

Due to a sharp reduction in portion or cancellation of drugs, dizziness, nausea, headaches, dry mouth mucous membranes, vomiting, anorexia, fatigue, irritability, drowsiness, disorientation, or anxiety may occur. There is also diarrhea, hyperhidrosis, insomnia and paresthesia. Usually, these signs have a weak expression and disappear on their own.

Overdose

Poisoning is manifested by such signs: changes in ECG parameters (prolongation of the QT-interval, as well as blockage of the leg in the bundle bundle), ventricular tachycardia, bradycardia, seizures, decreased blood pressure and changes in consciousness.

Especially dangerous is intoxication in combination with the use of alcoholic beverages or psychotropic drugs. There are also reports of fatalities.

There are no special antidotes for the drug, symptomatic procedures are carried out, accompanied by monitoring the work of blood flow and respiratory organs.

To reduce the absorption of Venlaxor, it is necessary to use activated charcoal. Induction of vomiting is not recommended, because there is a risk of aspiration. Dialysis procedures are not effective.

[5], [6], [7], [8], [9], [10], [11], [12], [13],

Interactions with other drugs

It is strictly forbidden to appoint Venlaksor with MAOI. If MAOI were used to treat a patient, Venlaxor can be prescribed only after 2-3 weeks after the end of the previous course.

The combination with haloperidol potentiates the medicinal properties of the drug due to the fact that such a combination increases the plasma level of drugs.

The combination with clusepidom increases the level of medication in the blood, which can lead to the development of epileptic seizures.

The use of warfarin together with Venlaxor increases the anticoagulant effect of the first drug.

There is a change in the medicinal characteristics of the individual when it is combined with the drug.

Medication potentiates the effect of ethanol, so it can not be used in combination with alcohol.

[14]

Storage conditions

Venlaksor is required to be kept in a place closed from penetration of moisture. The temperature level is a maximum of 25 ° C.

[15]

Shelf life

Venlaxor can be used for 3 years after the release of the drug.

Reviews

Venlaxor usually receives positive feedback about its action during the treatment of severe forms of long-lasting depression, against the background of which there is an anhedonia, apathy and a sense of anguish. Patients talk about the return of strength and appetite, improving the mood and restoring a positive perception of the surrounding reality.

But there is also a group of patients who talk about poor drug tolerance and the development of side-effects.