Zodak

Zodak is an antiallergic medicine of the second generation, which has a prolonged type of therapeutic effect.

Indications of the zodak

It is used to eliminate the following violations:

• Pollinosis;
• conjunctivitis of an allergic nature, as well as a runny nose (having a seasonal or year-round character);
• an itchy form of an allergic dermatosis;
• urticaria  (this includes the chronic stage of hives of idiopathic nature);
• angioedema.

Release form

Release of the medicine occurs in tablets, drops, and also syrup.

Tablets are packed in blister plates, 7 or 10 pieces each.

The syrup is contained in glass bottles with a capacity of 100 ml. Inside the box - 1 such a bottle, to which a measuring spoon is attached.

Drops are produced in glass bottles with a volume of 20 ml. In the pack, in addition to the bottle, there is also a special lid-dropper.

Pharmacodynamics

The active element cetirizine is an integral part of the group of competitive histamine antagonists. The component helps to block the end of H1 histamine, and at the same time has almost no cholinolytic and antiserotonin effect. Has a strong anti-allergic effect, while also providing antipruritic and antiexudative effect.

The drug weakens the severity of allergy symptoms at an early stage. In addition, it reduces the degree of movement of inflammatory cells. The drug suppresses the processes of excretion of the conductors participating in the manifestation of late signs of allergy.

Together with this, cetirizine eliminates smooth muscle spasms and strengthens the strength of capillaries, thereby preventing tissue puffiness. Helps reduce the severity of skin reaction to the use of histamine and specific allergens, and in addition to hypothermia (if a cold-type urticaria develops).

The use of medicament in a therapeutic dose does not cause a sedative effect and does not lead to a feeling of drowsiness.

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Pharmacokinetics

After ingestion of drops, tablets or syrup, the active element is rapidly absorbed from the digestive tract. Peak values within the body of the drug reaches 0.5-1 hour after admission.

The use of food has almost no effect on the degree of absorption, but taking drugs simultaneously with food results in a slight decrease in the rate of absorption.

Synthesis with blood protein is about 93%. The medicine does not pass into the cells, but also through the BBB.

Metabolic processes are carried out inside the liver, resulting in the formation of inactive metabolic products.

When taking drugs in a dose of 10 mg for 10 days, no cumulation of the active element within the body is noted.

Most of the medication in unchanged form is excreted through the kidneys. After a one-time use of the drug, its half-life is about 10 hours. If the drug is taken by a child aged 2-12 years, the half-life of the substance is reduced to 5-6 hours.

If the patient has problems with kidney function or if he undergoes hemodialysis procedures, the half-life expands to three times, and the clearance rate is reduced by 70%.

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Dosing and administration

The medication can be used only with the permission of the doctor - to avoid the development of complications. Zodak is used orally, and the medicine is not tied to eating.

Scheme of use of medicinal tablets.

Swallow tablets need to be whole, after which wash down with plain water. Adolescents over 12 years of age, as well as adults, should take 1 tablet once a day.

The size of the dose for children from the age group of 6-12 years is 1 tablet per day - it is taken in 1 dose or 2 times (0.5 tablets in the morning, and also in the evening).

The sizes of servings to the elderly are chosen by the attending doctor. Individually determine and the size of doses for people with disorders of renal activity.

Mode of application of syrup.

Adolescents from 12 years and adults are prescribed a single dose per day of 2-dimensional spoons of syrup.

Patients from the age group 6-12 years should take 2 measuring spoons of the medication once a day or divide the dose into 2 receptions - 1 spoonful in the morning and then in the evening.

Children aged 2-6 years should be given a 1-day measuring spoon (1 dose or divide by 0.5 tablespoons in the morning, and then in the evening).

People with kidney failure should reduce the size of the taken portion twice. For elderly patients who have no problems with kidney function, a dose change is not required.

Mode of use of oral drops.

Before using drops, dilute them in plain water. For adolescents from 12 years and adults, 20 drops of drugs are prescribed once a day. It is recommended to take the drug in the evening.

Age children's category of 6-12 years suggests the appointment of 20 drops once a day or 10 drops with a double use (in the morning, and then in the evening).

Children aged 1-2 years should be given 5 drops of LS twice a day.

People with kidney failure need to reduce the size of the portions of the drug in half.

Use of the zodak during pregnancy

Zodak can not be given to nursing mothers, as well as pregnant women.

Contraindications

Contraindication is a strong intolerance with regard to medicinal components.

With caution, it is necessary to prescribe the drug to persons with chronic kidney failure, and in addition to the elderly.

Side effects of the zodak

The medication is usually tolerated without complications, although sometimes with its use there are some side-effects, because of which use the medicine with caution, following the instructions.

Among the possible negative reactions:

• disorders of digestive activity: dryness of oral mucosa and manifestations of dyspepsia;
• disorders of the NS function: sensation of excitation, fatigue, drowsiness, as well as dizziness, migraine and headaches;
• symptoms of allergies: rashes, hives, and in addition, edema Quincke.

[6]

Overdose

Because of the poisoning of the drug in patients can develop such negative symptoms: a feeling of drowsiness, as well as retardation, weakness and severe fatigue. Tachycardia and headaches also occur. Perhaps the appearance of a feeling of irritability, constipation, dryness of the oral mucosa and delay in the process of urination.

To eliminate the overdose, symptomatic measures should be taken. The medicine does not have an antidote. Gastric lavage is performed and activated carbon is administered.

Interactions with other drugs

Combined use of the drug with theophylline (in a dose of 0.4 g / day) there is a decrease in the total values of cetirizine clearance, and the pharmacokinetics of theophylline remains unchanged.

Cetirizine does not affect the synthesis of warfarin with blood proteins. In the case of such a combination, the rate of absorption decreases, but its volume remains unchanged.

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Storage conditions

Zodak must be kept in a dry place, closed from penetration of children. The temperature is within the range of 10-25 ° C.

Shelf life

Zodak can be used for 3 years after the release of the therapeutic agent.

Application for children

Medication in tablets is allowed to prescribe to children over 6 years old, in syrup - for children from 2 years old, and drops for infants over the age of 1 year.

Analogues

Analogues of the drug are such drugs: Zetrinil and Allertec with Allerza and Letizen, and besides this, Cetirizin, Cetrin and Parlazin with Zirtek and Zincet.

Reviews

Zodak mostly receives positive feedback from patients. Among its advantages are not only high efficiency in the fight against allergic symptoms, but also low cost.

Positive about the drug in the form of drops respond parents who use the medicine to treat children. The administration of drops is very convenient, and with their use there are no side effects.

Concerning tablets, many positive reviews are left by people who suffered from allergic reactions for many years. They say that the pills helped to significantly improve the state of health at the stages of exacerbation of pathology.