Chlorophylline

Chlorophyllin is a disinfectant, it belongs to the category of antiseptics.

[1], [2]

Indications of the chlorophylline

It is used for septic infringements of staphylococcal character (arising from infections either after labor or operations), and in addition, with complications after staphylococcal nature after surgical procedures (purulent wounds and inflammations):

• burn diseases;
• endocarditis of staphylococcus origin in persons who underwent surgery in the region of the heart;
• pulmonary abscess, pneumonia, as well as pleurisy;
• inflammation of the peritoneum;
• endometritis;
• osteomyelitis;
• sepsis developing after abortion, and in addition subacute or acute inflammation of the internal organs of the genital system, not having a connection with abortion or the process of delivery;
• pyelonephritis or urosepsis purulent-destructive nature (combined treatment).

It is also prescribed for the elimination of diseases provoked by antibiotic-resistant microorganisms-agents of non-staphylococcus nature (for example, with tuberculosis, erysipelas and infections caused by listeria having any localization).

[3], [4]

Release form

The release occurs in the form of a concentrate for the manufacture of an injectable therapeutic solution on an alcohol basis, in ampoules of 2 ml capacity. Inside the box there are 10 such ampoules.

[5], [6], [7], [8]

Pharmacodynamics

Chlorophylline is an antiseptic that has antibacterial (bacteriostatic, and bactericidal) and etiotropic activity against staphylococci, resistant and dependent on antibiotics.

The drug is capable of eliminating plasmid resistance against antibiotics in various pathogenic organisms that provoke the development of bacterial infections. It also increases the level of oxygen inside tissues and has a pronounced detoxification effect. Because of this, it is often used in conditions during which there is a weakening of the immune defense, and in addition to eliminating tissue hypoxia and increasing the effectiveness of the antibacterial drugs used.

During the experimental tests, the tropism revealed by this drug for pulmonary tissues was revealed, as well as the absence of teratogenic and mutagenic, and yet carcinogenic and embryotoxic effects.

Bactericidal values of drugs inside the blood develop immediately after IV injection of 8 ml of 0.25% drug; bacteriostatic parameters are observed with the introduction of 4 ml of the drug. Within the limits of therapeutic values, the substance is kept for about 6 hours on average, so the most optimal solution is the use of drugs four times a day.

[9], [10], [11],

Dosing and administration

The drug should be slowly injected in / in the method. This procedure is used for pneumonia, septic disorders and burn diseases.

It is required to dilute a 0.25% solution of LS (2 ml) with sterile saline (38 ml). The proportions are thus 1k20. The medicine is manufactured by the method ex tempore. The finished solution should have a completely transparent appearance, without any precipitation or flakes.

The substance should be administered daily in / in the method at a dosage of 40 ml 4 times / day. This course lasts 4-5 days.

To treat pyotorax or peritonitis, you need to apply the drug every day for 5-8 days. It is necessary to introduce Chlorophylline into the pleural cavity by means of a drainage tube. Before the procedure, the drug should be diluted in novocain solution (0.25%), in a ratio of 1k20. The substance is manufactured by the method ex tempore.

[16], [17], [18], [19]

Use of the chlorophylline during pregnancy

Chlorophyllin is not allowed for pregnant women.

Contraindications

The main contraindications:

• the presence of hypersensitivity relative to the elements of the drug;
• lactation period;
• children under 12 years of age.

[12], [13],

Side effects of the chlorophylline

The use of drugs can cause the appearance of allergy symptoms (such as swelling of the oral mucosa and lips).

[14], [15]

Overdose

Intoxication can cause potentiation of adverse events.

To treat an overdose, symptomatic procedures are required.

[20], [21]

Storage conditions

Chlorophyllin is required to be kept in a dark place, where access to small children is denied. The temperature values are within the limits of 15-25 ° С.

[22]

Shelf life

Chlorophylline can be used for 5 years from the date of manufacture of the drug.

[23], [24], [25], [26]