Nasobek

Nasobek is a medicine with anti-allergic and anti-inflammatory properties, and besides it removes puffiness.

Indications of the nasobek

It is used to eliminate various types of rhinitis (among them allergic or vasomotor).

[1]

Release form

The release is carried out in the form of a suspension for the spray, in bottles with a volume of 100, 180 or 200 dosages.

[2]

Pharmacodynamics

The active component of the spray is an artificial SCS. It stimulates the production of an element lipomodulin (a substance that slows the activity of the enzyme phospholipase A), and besides this interferes with the binding of arachidonic acid. As a result, inflammatory exudation decreases, as well as lymphokine binding, inhibition of neutrophil accumulation takes place in the vascular walls.

There is also suppression of granulation and infiltration processes - this is facilitated by the fact that beclomethasone can suppress the movement of macrophages. There is a decrease in puffiness, the amount of mucus produced decreases, mucociliary movement improves.

The drug has good tolerability, even in the case of prolonged use. Symptoms of the disease are weakened 2-3 days after the start of the course.

Pharmacokinetics

After administration through inhalation, the substance is slightly absorbed into the body. A small part of the active ingredient that enters the digestive tract is destroyed inside the liver.

Part of the drug is excreted after 15 hours, while about 90% of the component is subjected to protein synthesis inside the plasma. Excretion occurs with feces, and the remainder of the substance is excreted by the kidneys.

Dosing and administration

The spray is administered by the intranasal method.

Starting from the age of 12, the medicine is prescribed in a dosage of 1-2 injections into each of the nostrils, twice per day.

Children aged 6-12 years per day are allowed to use not more than 400 mg. Usually they are given 1 injection in each nostril twice per day.

Continue the course is required until the moment when there is an improvement in the patient's condition.

Before the first use of the drug (or when used after a long pause), it is necessary to shake the bottle with the spray. Next, you need to do a few taps in the air until a white cloud appears. After that, you need to exhale, and pinch one nostril with your finger, while simultaneously injecting the spray into the other. Injection is performed on a sigh, after which it is required to exhale through the mouth. After this, repeat this procedure with another nostril.

Having finished the procedure, it is necessary to wipe the nebulizer using a handkerchief or a damp cloth.

In addition, it is recommended to clean the applicator at least once a week. It is required to remove the nozzle, rinse it with warm water, then dry it and put it back on.

Use of the nasobek during pregnancy

Apply Zabojek is prohibited on the 1st trimester. Cautiously appointed at the 2nd and 3rd trimesters.

Contraindications

The main contraindications:

• the presence of hypersensitivity in relation to any of the elements of the medication;
• hemorrhagic form of diathesis;
• propensity to have nasal bleeding;
• infection having a viral or fungal origin;
• tuberculosis in the respiratory system;
• children's age is less than 6 years.

Caution is necessary in such cases:

• hypothyroidism or glaucoma;
• in the period of breastfeeding;
• in the presence of ulcers or cuts in the nasal septum;
• with hepatic diseases or amoebiasis;
• with a recent myocardial infarction;
• in the period after operations on the nose or in case of damage to the nose.

Side effects of the nasobek

Occasionally, as a result of the application of the spray, there are such side effects:

• rash on the skin, hives, as well as angioedema;
• development of candidiasis;
• sensation of drowsiness or weakness, and in addition headaches and a disorder of taste or olfactory receptors;
• the appearance of bleeding, dryness in the region of nasal and oral mucous membranes, itching with burning sensation in the nose, and also coughing and rhinorrhea.

The following problems are sometimes observed:

• perforation of the nasal septum, as well as the appearance of ulcers in the nasal mucosa;
• thinning of bone structures and decrease in growth rates in children;
• loss of vision, glaucoma or conjunctivitis.

[3], [4],

Overdose

As a result of prolonged use in high dosages, the patient may develop hypercorticosteroids. To eliminate the violation, you need to cancel the medicine - you need to do this by gradually reducing the dosage.

Interactions with other drugs

As a result of the combination with phenytoin, and in addition ephedrine, rifampicin, phenobarbital, as well as glutetimide, a weakening of the drug effect of Nasobek is observed.

When combined with antithrombotic drugs, adrenomimetics, ingested anti-diabetic drugs, digitalis medicines, and indapamide, the likelihood of side effects on both sides increases.

The drug reduces the effectiveness of isoniazid.

When combined with systemic SCS and anti-asthmatic drugs, potentiation of their properties is observed.

[5], [6]

Storage conditions

The nursery should be kept in a place that is inaccessible to children. The temperature should be within 10-25 ° C.

Special instructions

Reviews

Nasobek receives mostly positive reviews. Often it is used to combat allergic symptoms, but in addition to eliminate signs of sinusitis, which can not be removed with the help of vasoconstrictor drugs. When combined with antibiotics, the medicine helps cure sinusitis.

Some patients who received dependence on vasoconstrictive drugs try to cope with it using Nasobek.

Among the merits is also noted the rarity of side effects, as well as a convenient spray form and a pleasant smell of medicine. In addition, patients note a fairly low price for drugs.

[7], [8]

Shelf life

Nasobek can be used for 4 years from the date of manufacture of the drug. The opened bottle with a spray can be used for a maximum of 3 months.