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Imunophane
Last reviewed: 23.04.2024
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Indications of the imunofana
It is used in the process of complex therapy in conditions of immunodeficiency or intoxication, as well as with inflammation of a chronic type of various origin. It is also used in adults with adjuvant treatment during vaccination against viruses and bacterial lesions.
Release form
Release in the form of a solution for sc and I / m injections, in ampoules of 1 ml. Inside the blister are 5 such ampoules. In a separate pack - 1 blister with ampoules.
Pharmacodynamics
The active substance of the drug is a hexapeptide with a molecular weight of 836D. The drug has deintoxication, immunomodulating, as well as hepatoprotective properties, promotes inactivation of peroxide and free radical ligaments. The effect of this peptide imunoksikedukdanta is due to the achievement of the three main effects of drugs: restoring the balance between the processes of oxidation-reduction inside the body, correction of the immune function, as well as slowing down the multiple medication resistance mediated by transmembrane protein transporters.
The effect of the drug on the production of specific antibodies having antibacterial and antiviral activity corresponds to the effect of medicinal vaccines. But Imunofan, unlike vaccines, has little effect on the production of reactants and immunoglobulins from the IgE subclass, without increasing the immediate manifestation of hypersensitivity. The drug helps to form the immunoglobulins that make up the subclass of IgA, if a person has an inborn deficit.
Imunofan with high efficiency copes with multiple resistance of tumor cells in relation to various drugs, and also increases their sensitivity to the influence of cytostatics.
Pharmacokinetics
The drug is completely absorbed from the site of administration of the solution, after which it undergoes a rapid disintegration into natural amino acids, which are its constituent elements.
Development of medicinal effect begins after 2-3 days (in the fast phase) and lasts for up to 4 months (in moderate as well as slow phases).
During the rapid phase, which lasts for about 2-3 days, first of all, the deintoxication effect of drugs develops - the antioxidant protective function of the body increases (by stimulating the production of lactoferrin with ceruloplasmin and increasing the activity of catalase action). The drug helps to stabilize the process of peroxide lipid oxidation, slows down the disintegration of the phospholipid cells located inside the membrane, as well as the binding of arachidonic acid, which lowers cholesterol and the production of inflammatory conductors. In the case of an infectious or toxic disorder with an effect on the liver, the drug prevents cytolysis and reduces serum bilirubin levels along with the activity of transaminases.
During the middle phase, which begins after 2-3 days, and lasts no more than 7-10 days, potentiation of the action of phagocytosis occurs and the number of perishing viruses with bacteria increases. In connection with the activation of phagocytosis, the inflammatory reaction of the chronic type, maintained by the persistence of antigens of bacterial or viral type, may be slightly exacerbated.
During the slow phase of the drug, which begins after 7-10 days and lasts up to 4 months, the basic values of humoral and cellular immune reactions stabilize. During this period, the immunomodulating index is restored, the production of specific antibodies and so on increases.
Dosing and administration
The solution is introduced in / m or in a / c way. Apply the medicine you need courses.
A single dosage of drugs per day for children over 2 years old, as well as adults, is 1 ml (50 μg). The attending physician prescribes the duration of the therapeutic course, taking into account the severity of the disease, the peculiarities of its course, and in addition the effectiveness of the use of drugs and its tolerability by the patient.
Standard medical regimens are described below, with the observance of which it is recommended to administer the drug to the patient.
During the treatment of oncological pathologies (as an aid in complex therapy - in combination with surgery and chemotherapy): inject injections every day, 1 time. Before chemotherapy, as well as conducting an operation, 8-10 injections of the solution should be administered, and then continue to apply the medication for the entire duration of the therapy.
During symptomatic or combined treatment in persons with cancer tumors at stage 3-4 of the disease, having different locations: administration of the solution every day once a day. The course includes 8-10 injection procedures, and then a break of 15-20 days is required, after which the above course is repeated. This treatment regimen is used throughout the period of therapy.
For children diagnosed with malignant diseases in the lymphatic or hematopoietic system: injections are performed once a day, and the entire course of therapy includes 10-20 injection procedures. It is necessary to prescribe the solution throughout the course of chemotherapy, and then after its completion - as a means of preventing the appearance of toxicosis.
With combined treatment, children with papillomatosis in the oropharynx with the larynx: do the injections once a day according to the schedule every other day. For the course, 10 procedures are required to administer the solution.
During the treatment of opportunistic infections (such as toxoplasmosis, herpetic or cytomegalovirus infection, pneumocystis pneumonia, chlamydia and cryptosporidiosis): one injection per day, the medication is administered every day. The course consists of 15-20 procedures of administration.
In the complex treatment of infections, the type of HIV: every day, inject the 1st injection. The entire course includes 15-20 injection procedures. If necessary, you can repeat courses, taking breaks between them lasting 2-4 weeks.
In combination with other drugs for the treatment of viral form of hepatitis (chronic type) or chronic form of brucellosis: every day for the first injection of the solution, a course requires 15-20 injections. To prevent relapse, it is necessary to repeat a therapeutic course every 2-3 months.
To eliminate diphtheria: every day to enter a 1-nu injection, in total for the course should be done 8-10 procedures. If a person is a diphtheria bacterium carrier, it is necessary to inject the solution every 3 days. In total it is necessary to perform 3-5 injection procedures.
As an auxiliary drug during treatment of people with severe burns, as well as signs of toxemia (with the development of septicotoxemia), with complications of purulent-septic nature or traumas in the limbs, and in addition for surgical patients suffering from septic form of endocarditis: everyday administration 1 injection of the solution, 8-10 procedures are performed for the entire course. If necessary, you can extend the course to 20 procedures.
During pulmonary diseases of obstructive type in chronic form, as well as in cholecystopancreatitis: injections are performed once every three days. For the course make 8-10 introductions. It is allowed to prolong therapy to 20 injection procedures, which are carried out with the above intervals.
Combined use in the elimination of psoriasis: everyday injections (1 time). The entire course of therapy consists of 15-20 procedures.
For adults during preventive vaccination: a one-time injection of the solution on the day of vaccination.
Use of the imunofana during pregnancy
Prescribe medication to pregnant women (if there is no risk of Rhesus-conflict with the fetus), as well as lactating women should, taking into account the risks for the child / fetus, as well as their ratio in comparison with the benefit from its use for the woman.
Contraindications
Among the contraindications: the presence of intolerance in relation to any of the elements of the drug, and in addition, a child under 2 years of age.
Interactions with other drugs
Special instructions
Reviews
Imunofan is considered to be quite effective and quick-acting medicine. Patients note that after the first procedure for the administration of the solution the condition improves. The reviews demonstrate that the drug works most effectively when eliminating pathologies of viral or infectious origin.
Shelf life
Imunofan can be used in the period of 2 years since the release of the drug.
Attention!
To simplify the perception of information, this instruction for use of the drug "Imunophane" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.