Berlition

Berlition is a medicine that affects the processes of metabolism and the work of the digestive system.

[1], [2], [3]

Indications of the berlition

The drug is mainly used in the treatment of alcoholic or diabetic polyneuropathy, in which paresthesia is also observed.

It is also permissible to prescribe in different hepatic pathologies.

Release form

Release of the drug is carried out in the form of capsules, tablets, and in addition to this concentrate for manufacturing infusion solutions.

Berlition 300 capsules of 15 pieces inside the blister. In the package there are 1-2 blister plates.

Berlition 300 ED - available in glass ampoules of 12 ml. Inside the pack - 5 or ten ampoules with concentrate.

Berlition 300 Oral - inside the blister contains 10 tablets. In a pack - 3 blister packs.

Berlition 600 capsules - 15 pieces inside the blister. In a separate package contains 1-2 plates.

Berlition 600 ED is contained in glass ampoules of 24 ml. In a separate box - 5 or 10 ampoules with concentrate.

Pharmacodynamics

Berlition - a medicine that contains α-lipoic acid. The active substance is a vitamin-like element that forms inside the body. Along with this, thioctic acid is a coenzyme involved in the oxidative processes of decarboxylation of α-keto acids. In people with diabetes, the drug helps to change the plasma indices of pyruvic acid.

The drug prevents the deposition of glucose in the region of matrix proteins within the circulatory system, and the formation of the final products of glycosylation processes. It also contributes to the improvement of endoneural circulation and activates the formation of glutathione (anioxidant component). Due to this property the preparation positively influences the work of peripheral nerves in people suffering from sensory polyneuropathy of the diabetic type. Along with this, the active component of drugs improves liver function in people with hepatic pathologies.

[4], [5], [6], [7], [8]

Pharmacokinetics

After internal administration, thioctic acid undergoes rapid absorption from the gastrointestinal tract. The level of absolute bioavailability of the substance (in oral form) is 20% compared with the use in parenteral form. This is due to the fact that α-lipoic acid undergoes the effect of the first hepatic transmission. Peak plasma index is observed after a half an hour after receiving.

The half-life of the substance is approximately 25 minutes.

Excretion mainly occurs through the kidneys - in the form of decay products, and the remainder of the substance is excreted unchanged.

In in vitro tests, α-lipoic acid forms bonds with ions of various metals, and in addition complexes of a moderate type of solubility with sucrose molecules.

[9], [10], [11], [12], [13], [14], [15]

Dosing and administration

Receiving tablets and capsules:

Take inside, whole, not chewing or grinding. The daily dosage of the medicine is used in 1 dose, preferably half an hour after breakfast. To obtain the required medication, all medical recommendations for use should be observed. Often, Burlion takes a long time, and the treatment scheme is appointed by the doctor.

For the treatment of diabetic type polyneuropathy, 600 mg of medication per day are usually taken (2 capsules or tablets of 300 mg form or 1 capsule LS form 600 mg).

To eliminate hepatic diseases, it is often prescribed to take 600-1200 mg of the drug per day.

During treatment of severe forms of pathology, it is recommended to use the drug in its parenteral form.

Concentrate used in the manufacture of infusion solution:

The substance contained in the ampoule is used in the manufacture of infusion. To dissolve the concentrate, only sodium chloride solution (0.9%) can be used. The finished substance is injected intravenously. The dosage of the finished infusion is 250 ml, which should be administered in a period of at least half an hour.

To treat the severe stage of diabetic type polyneuropathy, 300-600 mg of substance per day are required (1-2 ampoules of the drug in the form of 300 units or 1 ampoule in the form of 600 units).

Hepatic pathologies are severely treated with the administration of α-lipoic acid in the amount of 600-1200 mg per day.

The course of therapy with the parenteral method of administration is carried out in the period of a maximum of 0.5-1 month, and then the patient is transferred to the oral form of treatment.

In the case of infusion, there is a possibility of anaphylaxis, and if there is a feeling of weakness, as well as itching or nausea, the injection procedure should be stopped immediately. During the infusion of the patient must be constantly monitored, and only a medical professional can do this.

Persons with a diabetic form of polyneuropathy must comply with the required blood sugar (in addition, in case of the need to change the dosage of anti-diabetic drugs).

[21], [22]

Use of the berlition during pregnancy

It is forbidden to prescribe Berlion to pregnant or lactating mothers, because there is no information about the effects of the drug on the baby and the fetus.

Contraindications

Among the contraindications:

• It is forbidden to take people with intolerance of α-lipoic acid or other elements of the medicine;
• children and adolescents under 18 years of age.

Berlition 300 Oral can not be used in the treatment of persons with malabsorption syndrome, intolerance to lactase, and also with galactosemia.

Capsules are not prescribed for fructose.

Caution is necessary when used in people with diabetes (it is required to constantly monitor glycemia).

[16], [17], [18], [19]

Side effects of the berlition

Use of the medicine may cause the following side effects:

• manifestations in the gastrointestinal tract: the emergence of vomiting, dyspepsia and nausea, and with it a violation of taste buds and upset of the stool;
• reactions of PNS and CNS: with rapid IV injection may develop convulsions, a sense of heaviness in the head, as well as diplopia;
• disorders in the CCC region: with the rapid introduction of the drug in / in the method develops facial hyperemia (also in the upper part of the body), tachycardia, and in addition, constriction and pain in the sternum;
• manifestations of allergy: itching, rashes on the skin, and in addition eczema or urticaria. In some cases (usually using large doses of drugs) anaphylaxis may occur;
• Other: signs of hypoglycemia may appear, among which headaches, hyperhidrosis, dizziness and visual disturbances. Sometimes, because of the use of thioctic acid, purpura with thrombocytopenia or dyspnea is observed.

At the initial stage of the course of treatment in people with polyneuropathy paresthesias can be intensified, causing a feeling of "goosebumps".

[20]

Overdose

Due to the use of drugs in excessively large doses, nausea, headache, and vomiting may occur. If the dose continues to increase, the development of psychomotor agitation begins, as well as sensation of confusion. The use of more than 10 grams of the drug can cause severe poisoning, also fatal. The severity of intoxication with α-lipoic acid may increase in the case of combination of drugs with ethanol. As a result of severe poisoning, the appearance of generalized type convulsions, hemolysis with lactic acidosis and rhabdomyolysis is observed, in addition to lowering of sugar indices, deterioration of bone marrow function, development of shock state, DIC syndrome and multiple organ dysfunction syndrome.

The medicine does not have a specific antidote. In case of an overdose, the victim must be hospitalized. When intoxication with tablets or capsules requires gastric lavage and the use of enterosorbents. If severe poisoning has occurred, intensive therapy is necessary. In addition, symptomatic treatment is performed (if there are indications).

There is no information on the effectiveness of hemodialysis procedures, as well as hemofiltration in case of intoxication by Burleithin.

Interactions with other drugs

Do not take ethanol while using Berlion.

The active component of the drug weakens the effect of cisplatin in the case of simultaneous administration of these drugs.

The drug can potentiate the effect of antidiabetic drugs. During the use of Berlition in people with diabetes it is required to monitor glucose values and regulate the dosage of hypoglycemic drugs in accordance with them.

Thioctic acid forms complex bonds with individual metals, among which iron with magnesium, and in addition with calcium. The use of drugs containing these components, and in addition to this dairy product is allowed at least 6-8 hours after the use of Berlion.

[23], [24], [25], [26], [27]

Storage conditions

Concentrate for the manufacture of the infusion solution must be kept in a dark dry place, with temperatures in the range of 15-30 ° C.

The tablet form of the drug should be stored, protected from moisture, at a temperature of 15-25 ° C.

Capsules are kept in places that are closed from penetration of moisture, at a temperature of no more than 30 ° C.

Shelf life

Berlition in the form of a concentrate used for infusion solutions can be used in the period of 3 years from the moment of manufacturing of drugs, but at the same time the finished infusion (in a dark place) can be stored no more than 6 hours.

The tablet form of the drug can be used in the 2 years since the release of the drug.

The capsule form of Berlionium is allowed to be used in the period of 3 years (volume 300 mg) and 2.5 years (volume 600 mg) from the date of release of the capsules.