The solution is introduced exclusively in / in the method. The optimal concentration is a maximum of 5 mg / ml (infusion rate of the solution is a maximum of 10 mg / min). The duration of the procedure should not exceed 1 hour.
The size of the adult dose is 0.5 g or 7.5 mg / kg every 6 hours, or 1 g or 15 mg / kg every 12 hours.
For newborns at the first week of life, the initial dosage is 15 mg / kg, and then 10 mg / kg every 12 hours. Since the second week, the same dosage is required every 8 hours. Children from the 1st month should be given 10 mg / kg of medication every 6 hours or 20 mg / kg every 12 hours.
In persons with disorders of excretory renal function, the initial dose size is 15 mg / kg, after which the regimen is adjusted depending on the QC parameters (for anuria, the intervals between procedures are up to 10 days):
- the level of CC is more than 80 ml / minute - the standard dose is administered;
- the QC value within the range of 50-80 ml / minute - on the 1st g at intervals of 1-3 days;
- the QC value in the range of 10-50 ml / minute - enter 1 g at intervals of 3-7 days;
- the level of CC is less than 10 ml / min - for 1 g at intervals of 1-2 weeks.
Manufacture of an infusion solution:
It is required to dissolve the powder in injectable water in the proportion: for 500 mg of the drug, 10 ml of water is required; for 1 g of drugs - 20 ml of water (with a solution concentration of 50 mg / ml). This mixture is then diluted with a solution of sodium chloride (0.9%) or dextrose (5%) until a concentration of at most 5 mg / ml is obtained (proportions: 500 mg - 100 ml, 1 g 200 ml). The solution must be applied immediately.
Making an oral solution:
It is allowed to use Vancomycin for oral administration (to eliminate the pseudomembranous form of colitis, triggered by clostridium Diffile, and in addition to staphylococcal food-borne toxicity). The required dose should be prepared in 30 ml of water. Adults need to take 0.5-2 g of substance 3-4 times per day, and children - 0.04 g / kg at the same multiplicity.
The duration of the therapeutic course is within 7-10 days.