Nandrolone

Nandrolone is an anabolic steroid, has androgenic, antitumor and anti-anemia, as well as anabolic properties.

[1], [2], [3], [4]

Indications of the nandrolone

Among the indications:

• diabetic form of retinopathy;
• progressive stage of muscular dystrophy;
• spinal atrophy of muscles;
• the conditions at which a negative correlation of the element Ca2 + is observed (with prolonged treatment using SCS, and also with osteoporosis (poslimemacteric or senile form));
• strengthening catabolism, which reduces the body's internal resources (the development of steroid myopathy or infectious pathologies of a chronic nature, severe damage, extensive surgical operations);
• anemia that occur against the background of myelofibrosis, kidney failure, bone marrow myeloid aplasia (immune to standard treatment), and in addition with metastatic bone marrow lesions (malignant tumors) and treatment with myelotoxic drugs, as well as salts from the heavy metal category;
• malignant inoperable (with development of metastases) breast tumor in women during postmenopause or after ovariectomy procedure;
• delay in growth in adolescents, provoked by a deficiency in the body of somatotropin.

[5]

Release form

Produced in the form of an oil injection solution in ampoules of 1 ml. Inside a single pack is 1 ampoule.

[6], [7], [8], [9]

Pharmacodynamics

Nandrolone is a hormone, an artificial testosterone derivative. Its main active ingredient is nandrolone decanoate.

The drug is synthesized with special protein conductors located on the cell surface of target organs. As a result, the conductor-nandrolone complex is formed, which helps to move the latter through the cell membrane into the hyaloplasm, and then the substance from there penetrates the membrane of the nucleus into its cells, provoking the activation of the gene regulating the process.

The androgenic effect of drugs occurs by stimulating the binding of nucleic acids (such as DNA together with RNA) and structural proteins, and in addition, by enhancing the respiratory activity of tissues and the oxidative process of phosphorylation inside the skeletal muscles (against this background, cumulation of macroerges - such as ATP and phosphocreatine). Together with this medicine increases the volume of muscle mass and reduces the amount of fat deposits. It also activates the process of growing male genital organs together with the formation of secondary sexual characteristics (male type). The active component helps to stop skeletal growth and stimulates the process of bone calcification in the area of growth zones. Also, the drug accelerates the excretory activity of androgen-dependent glands - male genital (stimulates spermatogenesis), as well as sebaceous. High doses of drugs suppress interstitial cells, as well as lower the binding of internal sex hormones (by inhibiting the pituitary FSH production processes, as well as LH (negative feedback)).

Anabolic effects occur through the stimulation of healing processes in the epithelium (both glandular and integumentary), and in addition to muscle and bone tissue - activates the process of protein synthesis with structural cellular elements. The drug enhances the degree of absorption of amino acids from the small intestine (if the patient adheres to a protein diet), thereby creating a positive ratio of nitrogen values. Promotes the production of erythropoietin, as well as anabolic bone marrow processes (this property, in the case of a combination with iron drugs, causes an anti-anemic effect).

It interferes with the process of binding plasma factors (dependent on vitamin K group) of blood coagulation (types 2, 7, and also 9 and 10) occurring in the liver. In addition, it changes the nature of the lipid profile (increases the value of LDL, while reducing the level of HDL), and also increases the renal reabsorption of water with sodium, leading to the formation of peripheral edemas.

[10], [11], [12]

Pharmacokinetics

With intramuscular injection of 100 mg of drug, the peak value of the substance is observed after 1-3 weeks.

The process of biotransformation within the liver takes place, resulting in the formation of the element 17-ketosteroid.

Excretion is mainly carried out with urine (more than 90%), and about 6% is excreted with feces.

[13], [14], [15]

Dosing and administration

The solution is prescribed in the amount of 50 mg intramuscularly (once, with an interval of 3 weeks). If there is a disorder in the processes of protein metabolism, it is allowed to administer drugs in a reduced dose - 25 mg intramuscularly (1 time with a break of 3 weeks).

[22], [23], [24], [25], [26]

Use of the nandrolone during pregnancy

Pregnant medicine is contraindicated, because it has fetotoxic and embryotoxic properties, and besides it can provoke masculinization of the fetus (girls).

Contraindications

Among the contraindications:

• the presence of increased sensitivity to the elements of drugs;
• prostate cancer;
• Malignant neoplasms in men in the area of the mammary glands;
• breast cancer in women, complicated by hypercalcemia (since it can provoke the development of osteoclasts, as well as the process of resorption inside bone tissues);
• hepatic pathology (in acute or chronic form), among which also caused by alcohol;
• development of nephrotic syndrome or nephritis;
• lactation period.

[16], [17], [18], [19]

Side effects of the nandrolone

Due to the use of drugs, the following side effects may occur:

• both in women and men: Atherosclerosis is progressing (LDL level is increasing, and HDL is decreasing), peripheral puffiness and anemia (iron deficiency form), as well as dyspeptic phenomena (among them vomiting, epigastric pain or abdominal region, but also nausea). There may be a disorder in the liver, complicated by jaundice, as well as a leukemia-like syndrome (with changes in the values of the leukocyte formula and pain in the area of tubular long bones). Possible hypocoagulation, complicated by a tendency to develop bleeding, and hepatonecrosis (among the symptoms - bloody vomiting, darkening of stool color, discomfort, headaches and respiratory function disorder). There is a risk of developing liver cancer (manifested as urticaria, darkening of urine along with discoloration of feces, and besides the appearance of macular or spot hemorrhagic rash on mucous membranes and skin, and in addition to this development of angina / pharyngitis) and cholestatic form of hepatitis (skin and sclera are stained in yellow color, feces decolour, urine darkens, and in the right hypochondrium pain occurs);
• manifestations of violations exclusively in women: the development of virilism (coarsening voice, the size of the clitoris grows, amenorrhea and dysmenorrhea develop, the hair begins to grow in the male type), and besides this hypercalcemia (there is a feeling of severe fatigue, vomiting with nausea, and suppression of the CNS function);
• symptoms only in men: a segment of the prepubertal period - the development of virilism (penis size increases, acne develops, secondary sexual characteristics begin to form, and priapism develops), and hyperpigmentation of the skin (idiopathic type) also inhibits growth or complete cessation of growth (in the field of epiphyseal growth areas inside the tubular bones begins the process of calcification). During the post-pubertal period, there may be a tightening in the region of the mammary glands, priapism or gynecomastia, as well as problems with the bladder (urge frequency increases). In older men, it is possible to develop adenoma or prostate carcinoma.

[20], [21]

Overdose

As a result of drug overdose, there is an increase in negative manifestations.

In this case, it is necessary to cancel the use of the solution and to conduct therapy aimed at getting rid of the symptoms of the disorder.

[27]

Interactions with other drugs

There is a mutual increase in fluid retention within the body when the solution is combined with mineralocorticoids, as well as glucocorticoids, and in addition to food and drugs containing sodium and corticotropin. In addition, the likelihood of the appearance of edemas increases and the severity of skin acnes increases.

Combination with indirect anticoagulants, antiaggregants, as well as hypoglycemic drugs (the process of their biotransformation is suppressed) and insulin increases their effect. When combined with a solution of Nandrolone, the properties of the STG as well as its derivatives are weakened (the process of mineralization in the region of epiphyseal growth sites in tubular bones is accelerated).

The solution weakens the hepatotoxic properties of other drugs.

[28], [29], [30], [31]

Storage conditions

Keep the solution required in a place that is closed from sunlight, with a temperature mode of not more than 25 ° C.

[32], [33]

Shelf life

Nandrolone is allowed to be used in the period of 5 years from the date of release of the drug solution.

[34], [35], [36]