Rectal analgesics and anti-inflammatory suppositories: for back pain, menstrual supplements, for children

Sometimes people who encounter acute pain for one reason or another can not take pills or other dosage forms orally - orally. In such situations, other medications may come to the rescue - rectal anesthetic candles. This form of medicine does not affect the digestive process, absorbed through the rectal mucosa, due to which the components of the drug quickly enter the bloodstream and almost instantly relieve the painful sensations.

[1], [2], [3], [4], [5]

Indications of the rectal anesthetizing candles

Rectal analgesic suppositories will help in a short time to alleviate the condition of the patient with acute pain associated with:

• with hemorrhoids;
• with prostatitis;
• with painful menstruation in women;
• with osteochondrosis, radiculitis, arthritis, osteoarthritis, spondylitis;
• with migraine;
• with gout;
• with pains in the spine;
• with neuralgia, myalgia, traumas;
• with cystitis and other inflammatory diseases.

[6], [7]

Release form

The pharmacy chain can offer a large number of various rectal anesthetic candles, depending on the underlying cause and localization of pain, with or without anti-inflammatory effect.

Names of analgesic rectal suppositories

• When hemorrhoids are prescribed anesthetic suppository of both local and systemic action. For example, with a mild hemorrhoids, you can use a suppository with plant components - for example, sea buckthorn, or a suppository with calendula, and an anesthetic suppository - Anestezol. In more neglected cases, such rectal drugs as:
  • Proctosan-Neo is represented by active ingredients such as heparin (improves blood circulation and prevents thrombosis), prednisolone (stops inflammation and allergic reaction) and polidocanol (relieves pain and itching). Proctosan-neo is used to treat anal fissures and hemorrhoids in persons over 18 years of age.
  • Proctosol is a local anesthetic suppository based on bufexamak, bismuth and lidocaine. The drug is one of the analogues of the suppositories of Proctosan.
  • Anusole - an anesthetic candles, which are used for hemorrhoids and fissures in the anus. The drug is made on the basis of xerogene, belladonna, zinc sulfate. Anusole is not recommended for use in patients with arrhythmia, thyrotoxicosis and hypertension.
  • Relief is a known rectal anesthetic suppository based on phenylephrine - a substance that eliminates itching, discomfort and pain in the anus. Phenylephrine is not recommended for use with a strong increase in blood pressure, thromboembolism, thyrotoxicosis.
• With pain associated with prostatitis, these drugs will help:
  • Prostatilen is a unique suppository with a prostate extract and glycine. The drug is not toxic and practically does not cause side effects.
  • Vitaprost is a suppository based on the extract of the prostate, which is prescribed for chronic prostatitis and prostatic hyperplasia.
• With pains in the joints, such rectal anesthetic suppositories will be useful:
  • Rheumalgin is an anesthetic candles, represented by the active ingredient meloxicam (nonsteroidal anti-inflammatory drug). Rheumalgin is not suitable for the treatment of patients with bronchial asthma, gastrointestinal ulcers and bleeding, impaired blood coagulation.
  • Diclofenac is another representative of non-steroidal anti-inflammatory drugs. Helps with pain in the spine, neuralgia, myalgia, gout, colic. The drug is not recommended for erosions and ulcers of the digestive tract, as well as for serious disorders of hematopoiesis.
• To ease pain during menstruation, women often use:
  • Efferalgan - a safe suppository based on paracetamol, can be used in adults and children. Efferalgan is usually well tolerated by the body, only occasionally there may be a dyspeptic reaction.
  • Miralgan is a suppository with paracetamol, which can be used not only during menstruation, but also to eliminate headache, toothache, muscle pain, as well as injuries and burns.
  • Akamol-teva is a suppository with paracetamol, which have analgesic, antipyretic and anti-inflammatory properties.

Rectal analgesic suppository with monthly should always have any analgesic in the composition - for example, paracetamol. This component not only eliminates pain, but also has antipyretic effect. In addition, the drug refers to safe drugs, which is allowed to use even in childhood.

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Pain relief rectal suppository for children

Before assigning a rectal pain suppository to a child, the doctor must always establish the cause of the pain: the baby himself is not yet able to tell what exactly is bothering him. Therefore, it is not recommended to prescribe such drugs without diagnosis.

Of the most common children's analgesic rectal suppositories can be identified:

• Ibuprofen is an analgesic rectal child suppository based on a non-steroidal anti-inflammatory component. Ibuprofen can be used from 3 months of age for pain of mild to moderate intensity.
• Cefekon is a children's suppository based on paracetamol. Can be used to eliminate pain and high fever in children from 3 months. Up to 12 years.
• Viburkol is a homeopathic safe candle that is effective in childhood to eliminate toothache and cold symptoms.

Pharmacodynamics

The use of rectal analgesic suppositories can pursue two purposes: local anesthesia (eg, hemorrhoids or rectal inflammation) and systemic analgesia (with pain in other organs - for example, in joints or the prostate). In addition to the immediate analgesic, the majority of suppositories also contain antipyretic, antiplatelet and anti-inflammatory components. Suppositories of system use may contain non-steroidal anti-inflammatory substances: such suppositories include preparations with diclofenac, indomethacin - for example:

• Dicluberl candles 50, 100;
• the Voltaren candles;
• candles Diklovit;
• candles Diclofenac sodium, Diclofenac Pharmex;
• candles Naklofen.

To suppositories of topical application include Anestezol, Hemoprotekt, Gemorol, Novokain, Nigepan, Relief, Proctosan, Proctosol.

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Pharmacokinetics

The kinetic properties of rectal analgesic suppositories of local action are not considered, since the active ingredients of such medicines practically do not enter the systemic circulation.

As for rectal anesthetizing candles, which have a systemic effect, one can consider their kinetic properties by the example of non-steroidal anti-inflammatory drugs.

Absorption of the components of such suppositories occurs relatively quickly: the effect has been observed for half an hour. The maximum concentration in the blood is detected after about an hour.

The connection of the active ingredient with plasma proteins is more than 99%.

Kinetic parameters of suppositories do not change depending on the multiplicity and duration of drug use.

About 60% of the drug is excreted from the circulation with urinary fluid. At the same time, approximately 1% of the active non-steroid component is removed unchanged. The rest of the drug leaves the body with a fecal mass.

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Dosing and administration

To reduce the risk of side effects, any rectal analgesic suppository is used for the minimum possible period of time.

Rectal suppository is applied only rectally, without using other methods of drug administration.

Suppositories are injected deep inside the rectum: it is best if the procedure is performed after a preliminary cleansing of the intestine.

For a one-time withdrawal of pain use one candle, usually at night. If you have severe pain, you may need 2-3 times a day, depending on the doctor's appointment.

The duration of treatment is also determined only by the doctor, taking into account the cause of pain and the therapeutic effect achieved from the use of analgesic rectal suppositories.

[15],

Use of the rectal anesthetizing candles during pregnancy

Rectal analgesic suppositories in the first and second trimester are used only in cases where the expected effect of the drug is more important than the possible danger posed by the suppository with the analgesic for the fetus. If the suppository is still prescribed by a doctor to a pregnant woman, then their dosage and duration of treatment should be minimally possible.

In the third trimester, the use of any suppository with analgesics, including anti-inflammatory non-steroidal components, is contraindicated.

Active components of systemic suppositories in the vast majority of cases in a small amount can be found in breast milk. Therefore, such suppositories are not prescribed in the lactation period, in order to protect a newborn child from undesirable medication.

Contraindications

Rectal analgesic suppositories are not usually prescribed:

• with increased sensitivity to the composition of the candles;
• with exacerbation of peptic ulcer of the digestive organs, perforation complications and internal bleeding;
• with inflammation of the intestine;
• in the last trimester of pregnancy;
• patients with severe impairment of renal and / or hepatic function;
• patients with severe heart failure;
• for the treatment of postoperative pain after coronary artery bypass grafting;
• at a proctitis.

Suppositories based on non-steroidal anti-inflammatory components are not used to treat patients in whom any representatives of this series of drugs cause unwanted reactions, in the form of asthmatic attacks, Quincke's edema, skin rashes or allergic rhinitis.

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Side effects of the rectal anesthetizing candles

Adverse symptoms during treatment with rectal analgesic suppositories can be:

• changes in the picture of blood;
• allergic reactions;
• insomnia, irritability;
• noise in ears;
• tachycardia, chest pain;
• dyspepsia, diarrhea or constipation, bloating, colitis;
• disorders of liver function;
• redness and irritation of the anus;
• painful defecation, the appearance of mucus in stool;
• potency disorders.

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Overdose

Rectal anesthetizing suppository of local action is almost impossible to overdose. As for suppositories for systemic use, in this case, overdose can be manifested by headache, nausea, abdominal pain, mucosal bleeding, diarrhea, drowsiness, convulsions.

If the overdose is confirmed, the doctor prescribes symptomatic treatment with the setting of a cleansing enema and gastric lavage. Other additional measures are applied depending on the clinical condition of the patient.

[16], [17]

Interactions with other drugs

For rectal anesthetic suppositories of local action, no significant drug interactions were detected.

Suppositories with a systemic effect should be administered with caution together with diuretics, anticoagulants, oral non-steroidal anti-inflammatory drugs, agents for reducing blood sugar, antibiotics and cardiac glycosides.

More detailed information on drug interactions should be specified in the instructions for specific rectal suppositories.

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Storage conditions

Rectal analgesic suppository should be stored in a cool dark place, away from children's access, from heat sources and from sunlight.

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Shelf life

Shelf life of most suppositories - up to 3 years, but this point needs to be specified in the instructions.

Rectal analgesic suppositories can be dispensed in pharmacies, both at the presentation of the prescription and without it, depending on the active component of the candles. This question should be specified directly in the pharmacies or the treating doctor.