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Ecodax
Last reviewed: 23.04.2024
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Ecodax is an antimycotic for local use.
[1]
Indications Ecodax
It is indicated for the removal of dermatomycosis on the legs and other parts of the skin, the development of which is provoked by fungi that are sensitive to the action of drugs. They are also used for diseases complicated by superinfection (gram-positive microbes), with skin candidiasis, mycosis of the nails or auditory canal, and in addition, with pityriasis.
Release form
Available in the form of cream, in tubes of 10 g. One package contains 1 tube of cream.
Pharmacodynamics
The active ingredient is econazole, an imidazole derivative. The drug is an antimycotic with a wide range of effects. It has bactericidal and fungicidal properties.
The action of the active substance is due to the suppression of the biosynthesis of ergosterol, which is a regulator of the permeability of bacterial cell walls. Actively acts against yeast, as well as dermatophytes with mold fungi: trichophyton red, trichophyton interdigital, trichophyton crateriform, microsporum fluffy, Microsporum audouini and Microsporum gypseum, and in addition candida albikans, Torulopsis, rhodotorum, malassassia furfur (Pityrosporum orbiculare), causing pityriasis . Also flaky epidermophyton, aspergillus, cladosporium, Scopulariopsis brevicaulis and individual gram-positive microbes (staphylo- and streptococci, as well as Nocardia minutissima).
Pharmacokinetics
After local application to the skin, the systemic absorption of the active substance will be very weak. Although the bulk of the cream remains on the surface of the skin, the concentrations of drugs are found in the stratum corneum - they are much higher than the minimum drug concentration necessary to eliminate dermatophytes.
Drug concentrations are also observed in the outer skin layer and in the skin itself. Less than 1% of the dose is excreted together with feces, as well as urine.
[4]
Dosing and administration
The cream is used externally. For adolescents from 16 years and adults - treatment of injured areas in the mornings and evenings with a thin layer. It is required to wait for the full absorption of the cream.
Wet areas in the folds are required to dry before the treatment, using gauze. During the treatment of mycosis nails, the drug is applied 1 time per day under a sealed bandage.
Treatment is usually carried out within 2 weeks. But in the presence of disease in the highly keratinized areas (on the feet) the course can last for 1.5 months.
[7]
Use Ecodax during pregnancy
The drug was not tested for use in pregnant women. Since there is a systemic absorption, it is not recommended to prescribe during pregnancy.
There is no information as to whether econazole nitrate penetrates breast milk. As a result, the use of the cream during lactation is allowed only if the possible benefit to the patient exceeds the risk of adverse reactions in the fetus. It is not recommended to process the medicine around the pouch region, as well as the nipples themselves.
The cream does not affect fertility.
Contraindications
Side effects Ecodax
The use of the cream can cause such side effects:
- skin and subcutaneous areas: contact form of dermatitis, itching with burning, puffiness and rash, skin hyperemia, the appearance of irritation, blisters, the development of dryness. In addition, the development of urticaria, hypopigmentation, exfoliative changes in the skin, the appearance of irritation in the treatment site. Occasionally there is edema of Quincke, single-skin atrophy;
- immune system: increased sensitivity is rare;
- general disorders: discomfort or pain.
[6]
Interactions with other drugs
The systemic effect of econazole inhibits the elements of CYP3A / 2C29. But, given the weak absorption of the drug inside the systemic blood flow, the development of significant drug interactions is almost impossible.
When the drug is combined with oral anticoagulants (this is acenocoumarol or warfarin), it is required to carefully monitor the coagulation rates. You may also need to adjust the dose of the latter (sometimes even after the application of the cream).
It is not recommended to use Ecodax with other gynecological drugs (local or intravaginal), made on the basis of mineral or vegetable oils, as well as petroleum jelly.
Do not apply the cream together with condoms or diaphragms, as this interaction weakens their strength, as well as the effectiveness of the drug itself.
Storage conditions
Contain the cream is required in the usual conditions for medicines, inaccessible to young children. Temperature - no more than 30 ° С. Freezing is prohibited.
[11]
Shelf life
Ecodax is allowed to be used for 3 years from the moment of its release.
Attention!
To simplify the perception of information, this instruction for use of the drug "Ecodax" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.