Hormonal drug "Angelica" with menopause: how to take

At the onset of the perimenopausal period (menopause), many women have lower levels of sex hormones, which leads to a number of negative changes on the part of various systems and organs. So, for example, from the side of the reproductive system there is a decrease in sexual desire in women. In the organs of the genitourinary system, mucosal dystrophy occurs, so that women feel dryness in the vagina that causes itching. At the sexual certificate or act at women there is a morbidity and feeling of dyscomfort. On the urinary side, urinary incontinence is often observed. Reducing the number of sex hormones leads to disorders in the nervous system, which are manifested by severe irritability, depression, sleep disturbances. Reduces the production of collagen in the skin, resulting in deep wrinkles on the face. In addition, the symptoms of the perimenopausal period are manifested by hyperhidrosis, pain in the heart, bone tissue dystrophy (development of osteoporosis). With all these symptoms, you can fight with drugs designed for hormone replacement therapy. We suggest you familiarize yourself with one of these drugs - with the medicinal medicine Angelique, which is often used in menopause.

Anzhelik is a two-component combination medicinal medication, which consists of two components: the first - estradiol, the second - drospirenone. And as a part of this drug contains iron, magnesium and titanium.

Release form

Tablets that are coated with a coating containing estradiol - 1 mg, as well as drospirenone - 2 mg.

In a pack of cardboard is a blister with 28 tablets or 3 blisters, each having 28 tablets in each.

Pharmacodynamics

Estradiol, which is part of Angelica, is similar in its chemical structure and biochemical properties to the endogenous (human-produced) human estradiol, the second component, drospirenone, spiked from spironolactone, has progestin, antigonadotropic, contraceptive and anti-edematous (antimineralocorticoid) properties.

Estradiol compensates for the amount of estrogens in the body of women and relieves menopausal symptoms of the perimenopausal period, namely: mucosal dryness in the genital organs, hot flushes, hyperhidrosis and others. Especially important is the effect of estradiol on the body to prevent bone tissue dystrophy and prevent fractures of bones.

Drospirenone helps increase the release of water and sodium. This prevents the formation of edema in the body, increases blood pressure, helps prevent weight gain, reduces pain in the mammary glands, as well as prevents the growth of the inner layer of the uterus (endometrium) and minimizes the risk of developing a cancer of the rectum in the postmenopausal period. There is also the possibility of Angelica influencing the decrease in cholesterol in the body.

Pharmacokinetics

The active hormonal substance estradiol with internal (oral) use is absorbed for a short period of time, then absorbed in its entirety. During this process and when a hormone enters the liver, estradiol undergoes a metabolic process, it enters the compound with albumin, as well as with globulin, forming a bond with anabolic. Metabolization of this substance occurs more in the liver, as well as in the kidneys and different parts of the intestine, in the muscles, in the target organs and forms other less active substances, such as estriol, estrone and others. An increase in the content of estradiol in the blood can be achieved by repeated administration of the dose.

The substance drospirenone is also rapidly absorbed. After 1 hour, following the dose, the maximum concentration of the substance in the blood serum is observed. Drospirenone forms a bond with albumin, but does not combine with globulin. The main antrolam (metabolites) in the blood serum is the acid form of the hormonal substance drospirenone and 4,5-dihydro-drospirenone-3-sulfate. Both antrols are formed without the action of cytochrome. The depth of drospirenone contained in the serum forms 1.2 - 1.5 ml / min / kg. Part of this dose can be output unchanged. The overwhelming part of it will be excreted through the kidneys and intestines. The equilibrium saturation occurs after 10 days with continuous correct administration of the drug.

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Dosing and administration

The way how Angelica will be used, the doses - are set by the attending physician. Usually, if the patient does not use estrogens, and if she has switched to the constant use of Angelzik after taking another combination, then treatment can begin any day. Women who have used cyclic hormone replacement therapy will have to begin an individual course of treatment after the withdrawal bleeding ends.

The content of one package of Angelica is intended for a 28-day drug intake. One tablet per day is necessary. After a 28-day course of treatment with the drug, the next day, you need to start a new package of Angelique. And the first tablet from the package must be taken on the same day of the week, in which the first tablet was taken from the package, the previous one. It is recommended to apply the drug at the same time of the day every day. If the patient forgot to take the pill, then she should drink it soon. With prolonged skipping of the drug in a few days later, vaginal bleeding will occur.

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Contraindications

The use of Angelica is strictly contraindicated in the following circumstances and conditions:

• any kinds of thrombosis of vessels and thromboembolism of any organs, varicose veins;
• elevated levels of triglycerides in blood plasma;
• severe diseases and liver damage;
• any benign and malignant formations of organs or suspicion of them;
• any pregnancy and lactation;
• gynecological bleeding;
• acute and chronic diseases and pathologies of the kidneys, as well as the conditions after them;
• increased individual sensitivity of the body to the drug.

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Side effects of the angelik with menopause

When treatment with Angelic, side effects may occur. Often, from side effects of the drug, tenderness of the mammary glands, gynecological bleeding, pain occurring along the gastrointestinal tract. The most dangerous consequences of taking the drug are the development of thromboembolism and breast cancer. Then you can identify the following side effects:

• sharp changes in emotional state;
• headaches of varying intensity, up to migraine;
• pain in different organs and parts of the gastrointestinal tract;
• the formation of cervical (in the cervix) polyps.

In isolated cases, when the drug was treated with the drug:

• neoplasm in the liver;
• dementia;
• Endometrial neoplasms;
• increased blood pressure;
• increased concentration of triglycerides in the blood;
• changes in glucose tolerance by the body;
• proliferation of uterine fibroids;
• repeated exacerbation of endometriosis;
• adenoma of the pituitary gland;
• hyperpigmentation of the skin on the face;
• mechanical jaundice, as well as associated itch of skin and pituitary (mucous) membranes;
• appearance, as well as exacerbation of conditions, such as: bronchial asthma, Liebman-Sachs disease (lupus erythematosus), breast tumors.

Overdose

In the case of a single overdose of the drug, no acute side effects were observed. The increased dose of estradiol and drospirenone in a single application was normal transferred.

Symptoms of an overdose by Angelica: from the gastrointestinal tract - nausea and vomiting are possible, vaginal bleeding from the reproductive system. There is no antidote. Treatment of an overdose by Anzhelikom is symptomatic.

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Interactions with other drugs

Before the appointment of Angelica, it is necessary to inform the doctor about the medications the patient takes. When visiting other medical specialists, it is also necessary to warn them about taking Angelzik.

When used over a long period of time, some drugs, the effect of which can affect the production of liver enzymes (such as a series of anticonvulsant, as well as antimicrobial drugs). Such medications can affect the increase in the level of female sex hormones in the blood, thereby reducing their effectiveness. These properties have some of the anticonvulsants, barbiturates, primidone, carbamazepine and rifampicin, griseofulvin, topiramate, oscarbazepine, felbamate.

When taking certain types of antibiotics, most often tetracyclines and penicillins, there was a decrease in the amount of estradiol in the body.

In the treatment of arterial hypertension, in women using Angelique, there may be an increase in antihypertensive effect.

When treating Angelica, you should stop using alcohol. This is due to the fact that alcohol helps raise the level of estradiol in the blood.

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Storage conditions

The storage of the drug Angelique is provided in the place where the remedy will be inaccessible to children; at a temperature mode no more than + 25 ° C.

Shelf life

Shelf life Angelica 5 years from the date of production. Strictly contraindicated application after the expiry date indicated by the manufacturer on the package.