Vaccine against plague

In Russia, more than 20,000 people living in the territories of natural foci of plague (Altai, Dagestan, Kalmykia, Tyva, etc.) are at high risk of being infected with plague. Vaccination against the plague should be given to these people, as well as to persons working with live cultures of the causative agent of the plague. Every year, cases of plague are recorded in the states adjacent to Russia (Kazakhstan, Mongolia, China).

Used: Vaccine plague live dry for oral administration - freeze-dried live culture of the vaccine strain of the plague microbe EB line NIIEG with stabilizer and filler. One tablet contains one vaccination dose (40 ± 10) of 10 live microbes. Product form: 40 and 90 tablets in glass jars of light-protective glass. The drug is stored at a temperature of minus 20 ° ± 2 ° 3 years, allowed storage at a temperature of 2-6 ° 1 year. It is transported at T ° not higher than 10 °.

The live dry plague vaccination has been applied since 2 years of age, it is a freeze-dried live culture of the vaccine strain of the plague microbe EB of the NIIEG line with a stabilizer, it has the appearance of a dry porous mass of grayish-white color. Product form: 2 ml in ampoule (vial). The package contains 10 ampoules (vials). Store at a temperature not higher than 6 °. Shelf life 3 years.

Uses: plague vaccine live dry for oral administration - a lyophilized culture of live vaccine strain Yersinia pestis EV NIIEG line with the stabilizer and filler. One tablet contains one vaccination dose (40 ± 10) 10 living microbes. Product: 40 and 90 tablets in a glass jar from glass lighting. The preparation is stored at -20 ° ± 2 ° for 3 years, be stored at a temperature of 2-6 ° for 1 year. T is transported at no higher than 10 °C.

Vaccination against swine live dry applies to 2 years of age, it is a freeze-dried live culture vaccine strain Yersinia pestis EV NIIEG line with a stabilizer takes the form of dry porous mass of grayish-white color. Product: in 2 mL vial (vial). Package contains 10 ampoules (vials). Store at a temperature not exceeding 6 °. Shelf life 3 years.

Method of administration and dosage of vaccine against plague

Oral vaccine vaccinated with 14 years, once: one pill must be actively dissolve or chew thoroughly for 5-7 minutes. And then do not eat, drink or smoke for 30 minutes. Do not swallow the tablet entirely!

Live dry plague vaccine is administered once in 3 ways. Inhalations are held in a special room. In adults, simultaneous vaccination of one of the plague vaccines and the cutaneous against brucellosis and tularemia on different parts of the outer surface of the upper third of the shoulder is allowed.

Doses for vaccination plague live dry vaccine

Age	Vaccine dose (number of live microbes):
	Intracutaneous	Subcutaneous	Cutaneous
14-60 years	1 dose - in 0.1 ml (300 million)	1 dose in 0.5 ml (300 million)	1 dose-3 drops-0.15 ml (3 billion)
> 60 years	1/3 dose in 0.1 ml (100 million)	Do not vaccinate	1 dose-3 drops-0.15 ml (3 billion)
10-13 years	1/3 dose In 0.1 ml (150 million)	Do not vaccinate	1 dose-3 drops-0.15 ml (3 billion)
7-9 years	1/3 dose in 0.1 ml (100 million)	Do not vaccinate	2/3 doses - 2 drops - 0.1 ml (2 billion)
2-6 years	1/3 dose in 0.1 ml (100 million)	Do not vaccinate	1/3 dose-1 drop-0.05 ml (1 billion)

* - women breastfeeding, vaccinated only on the skin.

Both vaccines cause the development of immunity up to 1 year. Revaccination with both vaccines is carried out after one year, with an unfavorable epidemic situation - after 6 months. The same dose.

[5], [6], [7], [8], [9], [10], [11],

Reactions to the introduction and contraindications

Local reactions to oral vaccine against plague: limited, mild hyperemia of the oral mucosa in the region of the tonsils and slight pain felt when swallowing for 1-3 days and lasts 2-3 days. General reactions: fever for 1-2 days, malaise, headache, weakness, muscle pain. Before mass use, each vaccine series is tested in a group of 50-100 people, equivalent in age and health status to the main contingent of vaccinees. Vaccines are used if the frequency of local reactions does not exceed 45%, total weak (T ° 37.1-37.5 °) up to 3%, medium (T ° 37.6-38.5 °) not more than 2%, strong ( T ° above 38.5 °) not more than 1%.

Reactions to vaccinations of live dry vaccine are described in the instructions attached to the vaccine. Thermometry on the day of vaccination is required, at 37 ° and above it lay. Contraindications for oral plague vaccine, in addition to general, are:

• Systemic diseases of the connective tissue;
• Common Recurrent Diseases of the Skin ;
• diseases (endocrinology) Diseases of the endocrine system.

For live dry vaccine they are added to:

• Allergic diseases
• Chronic diseases of the respiratory system (with inhalation method).

[1], [2], [3], [4],

Reactions to the introduction

Local reactions to the oral vaccine against plague: limited, weakly expressed hyperemia of the oral mucosa in the area of the tonsils and slight pain felt when swallowing 1-3 days and last for 2-3 days. Systemic reactions: fever for 1-2 days, malaise, headache, weakness, muscle pain. Before each series of massive use of the vaccine was tested in a group of 50-100 people, equivalent in age and health status main contingent imparted. Vaccines are used, if the frequency of local reactions did not exceed 45%, the overall weak (T ° 37,1-37,5 °) and 3%, mean (T ° 37,6-38,5 °) of not more than 2%, strong ( T ° above 38.5 °) of not more than 1%.

Reactions to the vaccination of live dry vaccine described in the instructions supplied with the vaccine. Thermometry daily obligatory vaccinations at 37 ° C and above it lay.