Pills for impotence: help in restoring male power

Indications for use of pills for impotence - treatment of erectile (sexual) function disorders in men, with the exception of cases when this dysfunction is caused by mechanical causes (including injuries of the external genital organs), as well as with damage to the genital centers in the spinal cord and prostate inflammation glands or urethra.

 

The main names of pills for impotence: Sildenafil (Viagra), Tadalafil (Cialis), Vardenafil (Levitra, Staxin), Impaza, Tribestan.

[1], [2], [3], [4]

Pharmacodynamics

The mechanism of action of tablets from impotence Sildenafil (Viagra) has the active substance phenylsulfonyl-4-methylpiperazine, which acts by selective inhibition of the enzyme phosphodiesterase-5, which ensures the breakdown of cyclic guanosine monophosphate (cGMP), a nucleotide that controls the hemodynamics of the external genital organs. The result of this effect is an increase in the content of nitric oxide in the blood (secreted by the cells of the inner surface of blood vessels) and relaxation of the smooth muscles of the cavernous sinuses, which leads to the filling of the arteries and penis with blood and its influx into the spongy tissue of the penis.

The same pharmacodynamics in tablets Tadalafil (Cialis) and vardenafil (active ingredient - vardenafil monohydrochloride trihydrate).

Impaza is a homeopathic remedy, and its effect on erectile function occurs due to the activation of NO synthetase - an endothelial enzyme, which contributes to the release of nitric oxide and an increase in the level of cGMP in smooth muscle fibers. And then everything happens in the same way as when using Sildenafil or Cialis.

The potency-enhancing pharmacological action of Tribestan tablets is based on the properties of the medicinal plant of Tribulus terrestris, which contains furostanol steroid glycosides with anabolitic properties. This drug increases the synthesis of testosterone in the body of a man, which has a positive effect on erections.

[5], [6], [7], [8], [9], [10], [11], [12]

Pharmakinetics

Tablets from impotence Sildenafil, Tadalafil, Vardenafil after oral administration are absorbed in the gastrointestinal tract, enter the bloodstream and bind to proteins; The maximum content in the plasma is noted in 2-5.5 hours.

The bioavailability of Sildenafil does not exceed 40%, Tadalafil and Vardenafil varies depending on the age and functional condition of the liver.

The biotransformation of the active substances of these drugs is carried out by cytochrome enzymes of the liver, the metabolites are largely eliminated by the intestines with feces, and only slightly more than 12% are excreted by the kidneys with urine. The half-life ranges from 3 to 4 hours, Tadalafil - almost 18 hours.

Pharmacokinetics of Impaza and Tribestan are not presented in official instructions.

[13], [14], [15], [16],

Dosage and administration

Tablets for impotence must be taken orally: Sildenafil 0.25 g every two days; Tadalafil - 1 tablet (the desired effect appears after 20 minutes and lasts more than 30 hours). The initial single dose of vardenafil is 10 mg (taken 30-60 minutes before the alleged intimacy), an increase in dosage to 15-20 mg is acceptable.

Tribestan is recommended to take a pill three times a day (with meals), and Impaza tablets do not swallow, but are kept in the mouth until dissolved: one tablet 120 minutes before expected sexual contact and the second 60 minutes.

An overdose of tadalafil and vardenafil leads to more intense manifestations of side effects.

[23], [24], [25],

Contraindications

The main contraindications indicated in the instructions are as follows:

Sildenafil - diseases of the cardiovascular system (including a heart attack or stroke), low blood pressure, severe liver failure, congenital retinal degeneration of the eye.

Tadalafil and vardenafil - heart disease (coronary artery disease, angina pectoris; history - heart attack, stroke), hypertension or hypotension, leukemia, diseases of the external genitalia, and involuntary erection (priapism) and its extension.

Impaza - hypersensitivity to homeopathic components.

Tribestan - poor blood clotting.

[17], [18], [19], [20], [21]

Side Effects of Impotence Tablets

Below is a list of the most common side effects of impotence pills:

Sildenafil - headache, heartburn;

Tadalafil - headache and muscle pain, dizziness, dyspepsia, redness of the face and eyes, nasal congestion;

Vardenafil - urticaria, changes in blood pressure, rhinitis, abdominal pain, vomiting, belching, convulsions, sleep and stool disorders, dizziness, headaches, numbness of the extremities, memory problems, blurred vision (due to increased intraocular pressure;

Tribestan - allergic reactions, nausea.

[22]

Interactions with other drugs

The interaction of pills from impotence with other drugs is that

• the simultaneous use of vardenafil or tadalafil with nitroglycerin and other drugs of the nitrate group is unacceptable;
• co-administration of sildenafil and alpha-adrenoreceptor inhibitors reduces blood pressure,

Tadalafil may increase the vascular toning effect of antihypertogic drugs; while anti-heartburn remedies reduce the effects of tadalafil itself.

The optimal storage conditions for all tablets from impotence - at normal room temperature; The shelf life is 24 months (Tadalafil products - for three years.

[26], [27], [28]