Effective suppository against high temperature

When a child is sick, it is very unpleasant for parents. Mom and Dad start to panic and do not know how to treat a baby, especially if he is very small. In this case, the suppository is actively used against temperature. They allow not only to adjust the temperature regime, but also to alleviate the condition of the baby. Many parents are sure that they will cope with the problem, they can independently, but this is far from being the case. In many cases, you can not do without special medical preparations. Therefore, the most popular and effective candles will be presented below, which will help the child cope with the cold and its consequences.

[1], [2], [3], [4], [5], [6]

Indications for use of suppositories from temperature

Indications for use may vary, depending on the drug itself. Therefore, this issue will be considered from the point of view of suppositories Viferon. The drug is widely used for infectious and inflammatory diseases. It can be used as an independent tool, and in combination with other medicines. These suppositories eliminate the acute respiratory viral infection, influenza, pneumonia, meningitis, sepsis from temperature.

Together with other medicines, he actively fights against chronic viruses, including hepatitis. It is used for viral hepatitis, which has a pronounced activity. It is recommended to use it for adults and pregnant women with urogenital infection. It can be chlamydia, trichomoniasis, a herpetic infection of the skin, vaginal candidiasis.

In addition, the drug is widely used in complex treatment of influenza, as well as when eliminating catarrhal diseases. Even if they are complicated by a bacterial infection.

Form of issue

Preparations of this type are released in the form of suppositories, namely candles. They have a white color with a yellowish tinge, a bullet-like shape. The form of the suppository may vary depending on the agent used. Typically, the suppository from the temperature has a streamlined shape, which facilitates their introduction.

The diameter of the suppository should not exceed 10 mm. The main active substance is interferon or paracetamol. In the case of Viferon, it is an interferon. The auxiliary substances are: α-tocopherol acetate - 55 mg, ascorbic acid - 5.4 mg, sodium ascorbate - 10.8 mg. Additional action is achieved due to the content of disodium edetate dihydrate - 100 μg, polysorbate 80 - 100 μg, cocoa butter base and confectionery fat - up to 1 g.

In the package there are 10 candles, packings of cellular contour. The pack itself is cardboard, it contains no more than 10 suppositories. They have a homogeneous constitution, heterogeneity of color is allowed. There is a so-called marbling. On the longitudinal section there may be a funnel-shaped depression.

[7], [8]

Pharmacodynamics

The drug Viferon is a preparation of human recombinant interferon alfa-2b. It has a pronounced antiviral effect. In addition, these suppositories from temperature are antiproliferative and immunomodulating.

Immunomodulating properties consist in enhancing the phagocytic activity of macrophages. The agent is able to increase the specific cytotoxicity of lymphocytes to target cells. The drug causes mediated antibacterial activity.

As part of the drug is ascorbic acid, which, together with alpha-tocopherol acetate, increases the specific antiviral activity of interferon. As a result, there is an increase in its immunomodulatory action. This allows to significantly increase the effectiveness of the immune response of the body to the penetration of viruses into it.

With the use of the drug, the level of secretory immunoglobulins belonging to class A also increases. Normalization of the level of immunoglobulin E, as well as restoration of the functionality of the endogenous system of interferon.

Ascorbic acid together with alpha-tocopherol acetate are highly active antioxidants. They have a number of properties. Regenerating properties, anti-inflammatory and membrane-stabilizing action. It was found that the drug does not cause negative reactions from the body. All this is due to the fact that interferon is not capable of forming antibodies.

Pharmacokinetics

Drugs that lower body temperature, absorbed and distributed in the body in a special way. Thus, absorption occurs from the gastrointestinal tract. The maximum concentration of the suppository from the temperature is reached one hour after application. Binding to plasma proteins occurs by 15%.

Metabolism occurs in the liver. 80% of the agent can react with glucuronic acid and sulfates. At 17%, it undergoes hydroxylation, the result of which is the formation of active metabolites. Over time, they are conjugated to glutathione, forming inactive metabolites. When fixing glutathione, metabolites are able to block enzyme systems of hepatocytes. In the end, necrosis may develop. The half-life is 3 hours. The drug is excreted within a day at 84-95% of the kidneys, unchanged.

In special cases, bioavailability in children is similar to that of adults. The main metabolite of paracetamol is paracetamol sulfate, this applies to children under 10 years of age. In children older than 12 years, the metabolite is conjugated glucuronide.

Names of suppositories from temperature

To date, there are many names of suppositories that help to fight fever. These include Efferalgan, Cefekon D, Viferon, Nurofen, Genferon, Analgin, Panadol, Ibuprofen, Papaverin, Diclofenac and. It is worth considering these suppositories from the temperature in more detail.

• Efferelgan. The agent is applied rectally. It is necessary to release the suppository from the package and insert the baby into the anus. The dosage depends on the weight of the baby. The average dosage is 10-15 mg / kg 3-4 times a day. Medication can not be used for: problems with the functionality of the liver or kidneys, hypersensitivity and newborns up to 3 months. Side effects in the form of allergic reactions, anemia, nausea, vomiting and leukopenia are not excluded. If you experience this symptomatology, it is worthwhile to see a doctor.
• Tsefekon D. The agent is used rectally, immediately after the purgative enema. To children, at the age of up to 6 months, 1,5-2 suppositories are sufficient for 0, 05 mg 2-3 times a day. At the age of 12 years, 0.25 mg 2-3 times a day. Use the product is not necessary in the presence of problems with the liver and kidneys, intolerance, alcoholism. Do not exclude such reactions as thrombocytopenia, renal colic and allergic reactions.
• Viferon. The drug is applied rectally. Take it one suppository 2 times a day at intervals of 12 hours. Dosage depends on the condition of the baby and the characteristics of the body. Take the drug can not be intolerant of its main components. It is usually well tolerated by children and does not cause side effects.
• Nurofen. Dosage is prescribed depending on the weight of the child. Single dose does not exceed 5-10 mg / kg 3-4 times a day. Use the drug is not possible with blood diseases, intolerance, ulcerative lesions of the digestive tract. Negative reactions of the body: nausea, vomiting, allergic reactions, rarely - tachycardia and increased blood pressure.
• Genferon. The drug is used twice a day for 5 days. In rare cases, it is used for 10 days. It should not be used by children who are hypersensitive to the main components of the drug. Negative reactions from the body cause rarely, mainly in the form of allergic reactions.
• Analgin. At the age of up to one year, the drug is used in half of the suppository per day. From year to 3 years, one suppository, more than 4 years, 2 suppositories. This issue must be solved with a child's doctor. Use the drug should not be under the age of 3 months, hypersensitivity, violations of the liver and kidneys. It often causes side effects in the form of a disorder of the gastrointestinal tract.
• Panadol. The drug is used rectally. The dose depends on the child's age and weight. The average dosage is 10-15 mg / kg 3-4 times a day. Take the remedy is not possible in violation of liver and kidney function, intolerance and blood diseases. Possible side effects in the form of nausea, vomiting and allergic reactions.
• Ibuprofen. The dose for a child depends on his age and weight. The average dosage is 5-10 mg / kg of weight, 3-4 times a day. Contraindications include bronchial asthma, inflammatory processes in the intestine, renal or hepatic insufficiency. Possible side effects in the form of gastrointestinal disorders and allergic reactions.
• Papaverine. The dose is prescribed by the doctor depending on the age of the baby. Up to 6 months, 5 mg per day, over three years - 10 mg per day, 10-14 years - 20 mg per day. Do not take the drug with hypersensitivity. Not excluded: allergic reactions, nausea, vomiting.
• Diclofenac. The drug should be taken exclusively under the supervision of a doctor. Enough half of the suppository per day. The exact dosage is prescribed by a specialist. The agent can not be used in inflammatory processes in the intestine and all its damages. Care must be taken. The drug causes side effects, in the form of itching, burning and discomfort in the anus.
• Laferobion. The agent is used for one suppository for 5 days. If necessary, 2 suppositories with an interval of 12 hours. Use of these suppositories is impossible with intolerance, problems with the liver and kidneys, as well as severe cardiovascular diseases. Possible: headache, weakness, pain in the muscles and joints.

Cefecon

Rectal suppository has always been the most convenient form of medications. Their positivity lies in the fact that the temperature of the suppository can also be used for children. They are easy to use and effective. Unpleasant symptoms disappear after the first use of the remedy. The positive effect of the drug is achieved due to the active ingredient - paracetamol.

The dose should be prescribed by the observing pediatrician, depending on the child's age and weight. Usually, it is 10-15 mg per day. The duration of therapy is 5 days. The main indications for the use of the drug are: pain with injuries and burns, increased body temperature due to infection or cold, and toothache.

Despite the fact that the remedy is completely safe, it is advisable to apply it from 3 months of age. Increase the dose alone is not worth it, it can lead to negative reactions from the body. These include allergic reactions, swelling, an intestinal disorder. Use the drug is not suitable for children with violations of the liver and kidneys, as well as intolerance to paracetamol.

Viferon

Disease baby is always an extra reason for parents to worry. Together with modern means for colds there is nothing to fear. To overcome the flu and SARS will help the suppository from the temperature of Viferon. The agent is administered rectally 2 times a day for one suppository. It is important to maintain a twelve-hour interval between doses. Detailed information about dosing can be provided by the attending physician.

The active substance of the drug is interferon. Despite its effectiveness, it does not cancel side effects. Possible violations of the digestive tract and the development of dysbiosis. Therefore, it is not worthwhile to resort to increasing the dose yourself. Take Viferon is not possible with hypersensitivity, at the age of up to 3 months, as well as children with obvious violations of the liver and kidneys.

Usually the remedy is transferred very well and in pediatrics it is in the first place. It can create resistance to infections and improve the immune system. The active substance contributes to the development of antibodies, which actively fight with infiltrated bacteria and infections.

Nurofen

This drug has an analgesic effect and actively reduces body temperature. It is often taken by children with ARVI and influenza. These suppositories proved to be effective from the temperature, the positive dynamics is observed for 8 hours after using the drug. Therefore, it is sufficient to apply it 3-4 times a day for one suppository. The maximum dosage should not exceed 30 mg per kilogram of body weight. The agent is used not only at elevated temperature, but also headache, as well as toothache.

Despite its effectiveness, the drug should not be taken to children with increased sensitivity to ibuprofen, a violation of the functionality of the liver and kidneys, blood diseases, as well as hyperkalemia. The drug can cause and side effects, they manifest themselves mainly from the digestive system, often there is nausea, abdominal pain, an intestinal disorder. If you have negative symptoms, you should seek help from a doctor. Usually the drug is well tolerated.

Genferon

The drug contains an active component of interferon. It allows you to create a powerful barrier and not allow bacteria and viruses to penetrate the baby's body. These suppository from the temperature should be taken on the advice of a doctor, according to the individual dosage. Usually, one suppository is administered 2 times a day, a twelve-hour interval is observed between use. The duration of treatment does not exceed 5 days. If it is a question of urogenital infections, in this case the therapy is 10 days.

Like any other medicine, Genferon has a number of contraindications and side effects. Usually, the remedy is transferred very well, but in some cases, negative symptoms may occur. So, it is possible to reduce appetite, allergic reactions, dizziness and intestinal distress. Contraindications include persistent intolerance of the main component - interferon. Use medicament is not necessary for violations in the work of the kidney or liver, and also at the age of 3 months. Everything is done under the supervision of a doctor.

Papaverine

Any suppository when inserted into the intestine, guarantee a quick action. That's why the children are recommended to use them. Thus, there is minimal effect on the body. Take the suppository from the temperature you need at a certain dosage. At the same time, one or two candles can be introduced. It all depends on the state of the child. Usually appoint one candle 2-3 times a day. It is necessary to start from the child's age, weight and problem.

Do not use this product in any way for children with impaired conduction of the heart. A similar requirement is put forward for people with problems in the work of the kidneys and the heart. With caution, it is prescribed with a decrease in the functions of the thyroid gland, as well as chronic renal and adrenal insufficiency. With intolerance of the main components of the drug, it should not be taken. The drug can cause side effects, in the form of digestive disorders, weakness and headache.

Analgin

The drug is administered in a certain way: for babies from 6 months to a year, half the candle is enough, from 1 to 3 years - 1 candle, at the older age 2 suppositories. It is advisable to apply the suppository from the temperature after cleaning the intestine, you can make a cleansing enema. After the introduction, you need to lie for about 30 minutes in a horizontal position.

Analgin has certain contraindications about the application. So, it should not be used by children under the age of 3 months, with intolerance to the components of the drug, as well as violations of liver kidney function and hematopoiesis. This tool is not used so often because it causes a lot of side effects.

With rectal use, the negative effect of the medication is significantly reduced. But, despite this, it can cause the development of allergic reactions and oppression of hematopoiesis. With the simultaneous use of Analgin, other antipyretic and analgesic drugs are contraindicated. They can lead to increased toxicity of the drug.

[10]

Ibuprofen

You can use Ibuprofen 3-4 times a day, the dosage is prescribed by the observing doctor. It is calculated as follows: 5-10 mg of the drug per kilogram of the weight of the baby. Independently exceed the dose is not recommended, it can lead to an overdose. Before using the suppository against temperature, it is advisable to clean the intestines of the baby. Because the introduction of the drug can provoke its work and the suppository will come out together with the feces. Re-introduction of the drug is not recommended, because it is impossible to find out how much Ibuprofen has "mastered". Additional administration may cause an overdose.

Use the medication is not necessary in the presence of inflammatory processes in the intestine, intolerance of the main component of the drug, peptic ulcer and bronchial asthma. The use of ibuprofen is extremely necessary for newborns. The tool has a number of side effects, they arise against the background of non-compliance with the rules of use. In general, it is an allergic reaction and an intestinal tract disorder. If you use ibuprofen according to the instructions, no negative symptoms should arise.

Panadol

The average dose of the drug is: 10-15 mg per kilogram of weight. Usually the dosage is calculated by the attending physician, depending on the characteristics of the organism. As in all cases, the use of the suppository from the temperature is after cleaning the intestines. Panadol is administered 3-4 times a day every 4-6 hours. Dose changes are possible in extremely difficult cases with the permission of the therapist.

There are contraindications regarding the use of medication. Do not use it to children under the age of 3 months, with intolerance, as well as violations of the liver and kidneys. A similar requirement is advanced in the presence of blood diseases, inflammatory processes in the intestine. Side effects are not excluded. They arise mainly against the background of non-compliance with "contraindications" and with an independent increase in the dose of the drug. Thus, nausea, vomiting and the development of allergic reactions are possible. Very rarely observed: anemia and leukopenia.

Diclofenac

This tool can be used for children who have reached the age of twelve. To date, these suppositories from the temperature are not taken so often. They are effective, but in spite of this they have a lot of side effects. As for the dosage, it should not exceed one suppository per day. It is advisable to clean the intestines before use.

Do not take Diclofenac people with inflammation of the intestine and pathological processes in it. The remedy is not used even in the presence of hemorrhoids. Violation of the functionality of the kidneys, liver, cutaneous diseases and hypersensitivity - all this refers to contraindications. Now with regard to side effects. The first thing can be discomfort in the anus, it is characterized by the presence of itching and burning. Often there is a metallic taste in the mouth, pain in the right hypochondrium and general malaise. This drug has a negative effect on the body, but at the same time copes with its main task. Use it only if absolutely necessary.

[11], [12]

Laferobion

The medication is used 2 times a day for one suppository. There are no special instructions regarding the dosage. Despite this, the suppository from the temperature should be taken under the guidance of an experienced specialist. Laferobion helps to cope with many problems. Medication not only lowers the temperature, but also cures herpes, bronchial asthma and viral-bacterial infection. Duration of therapy is prescribed by a doctor.

The instructions say that the remedy has no side effects and is perfectly tolerated by the kids. But actually it is not. In some cases, general lethargy, weakness, headache and muscle pain were observed. As for contraindications, this drug as well as many others should not be taken in case of violations of the liver, kidneys and cardiovascular system.

Adverse events develop mainly on the background of uncontrolled use of medication, so you should follow all the recommendations of the doctor, this will avoid unpleasant symptoms.

Dolphin

This remedy is antipyretic, so it is often used at an elevated temperature in children. This medicine is not produced in Russia, it is manufactured in Egypt. The remedy had time to prove itself with a very good side. Dosage is desirable to learn from your doctor. Usually the suppository from the temperature is applied 2-3 times a day for 1 suppository. Everything depends on the child's condition, weight and age. Dilitelnost therapy is appointed indivydialnomu procedure.

Like other medicines, there is a number of contraindications. Do not use the remedy for intolerance to its main components. It is not desirable to use Dolphin in case of impaired functionality of the liver, kidneys and inflammatory processes in the intestine. Any suppository should not be used for cracks and problems in the intestines.

Side effects include allergic reactions. They can arise because of problems in the anus. It all appears in the form of itching, burning and general discomfort. Disorder of the intestine is not excluded. Therefore, use the drug with caution.

[13]

Homeopathic Candles

Homeopathic medicines managed to prove themselves with a very good side. All this is due to the content in them of only natural components. But, it is worth noting that not all people are helped by vegetable components and other substances based on them, which contain in their composition the given suppository from temperature. Therefore, the products of homeopathy should still be treated with caution. Especially if the treatment is child.

The main favorite among all drugs, is Vibrukol. This is a complex homeopathic drug that can suppress the inflammatory process in the body. In this case, it has an antispasmodic effect and acts as an analgesic. This is a great help in the presence of pains of a different nature. Most importantly, it can be used from the first days of life. There were no contraindications and side effects. But you should not use Vibrukol for intolerance to plant components. The dose of the drug should be prescribed by a doctor.

Pay attention to such drugs as: Belladonna, Hina, Aconite and Ferrum phosphoricum. Take them only under the guidance of a homeopath. They are based on plant extracts and are able in a short time to reduce body temperature.

Suppositories for children

Quite often, suppositories are used to eliminate the inflammatory process and lower the body temperature. They can reduce the possibility of developing side effects and have an exceptionally positive effect. You can take a suppository from the temperature at any age.

So, the safest are the Vibroxol suppositories. As mentioned above, this is a homeopathic remedy. It can reduce pain and temperature. Thanks to its plant composition, it does not have a negative effect on the body. But due to the fact that this is a homeopathic drug, it is worth to be cautious. Use it according to the recommendations of the doctor in an individual dosage. It should not be used with intolerance of the main components of the drug. Side effects are not revealed, but the possibility of developing an allergic reaction is preserved.

Panadol proved to be good. This suppository contains in its composition active ingredient Paracetamol. He, along with the auxiliary components, actively struggles with the inflammatory processes in the body. The dose is calculated taking into account 10-15 mg per kilogram of weight. The duration of therapy depends on the condition of the child. Contraindications and side effects have been described above.

Not the last role in the treatment of inflammatory processes in the body is given to Viferon and Nurofen. Additional information about them was presented below. Despite the effectiveness and safety, use any medicine, especially for children for the first time days of life need to be cautious.

Dosing and Administration

Only a specialist can prescribe a dose. If we are talking about children, then everything is calculated taking into account their age and weight. Usually, the average dose is 5-15 mg per kilogram of weight, depending on the drug used. To introduce a suppository from the temperature can be 2-4 times a day, again, it depends on the medication used.

Adult person is enough 1 suppository 3-4 times a day, with a periodicity of 4-6 hours. If it is a more powerful drug, such as Viferon, 2 suppositories are sufficient in the 12 hour interval. Independently calculate the dose and certainly prescribe treatment to your child is not recommended. It is necessary to know the characteristics of the body, and to determine the reason for the temperature increase. After all, it can be like a common cold, as well as a bacterial infection. The duration of therapy is 5 days, in some cases - 10 days.

[14], [15]

Use of suppositories against fever during pregnancy

In pregnancy, the use of any drug should be monitored by a specialist. During the period of gestation, it is recommended to give preference to herbal remedies with minimal side effects. The suppository from the temperature of Vibrokol has proved to be very good.

Almost all young mothers are familiar with this tool. Many women have to get acquainted with it even during pregnancy. Most often, the remedy is prescribed with an increased tone of the uterus, as well as the presence of inflammatory processes in the body, accompanied by inflammatory processes. This is a homeopathic remedy, therefore it is not able to do harm in view of its plant origin. But, despite this, it is worth remembering that homeopathic remedies do not pass any clinical studies, so you need to take extra care when taking them.

It should be noted that the suppository from the temperature is taken exclusively rectally. Even with an increased tone of the uterus, nothing is used vaginally. This will reduce the possible negative effects on the baby. During the carrying of a baby, it is strictly forbidden to use anything independently.

Contraindications to the use of suppositories from temperature

The main contraindication to use is the presence of hypersensitivity to the main components of the drugs. The main active ingredients are: paracetamol and interferon. Therefore, before using the drug, it is worthwhile to check with your doctor which suppositories are better to use from temperature, or more precisely on the basis of what.

Use of suppositories is prohibited in the presence of inflammatory processes in the intestine. It can be like cracks in the anus, and the presence of hemorrhoids. The use of suppositories can aggravate the condition and lead to the emergence of unpleasant symptoms.

These medicines contain powerful components. Therefore, if there are problems with the functionality of the liver, kidneys and cardiovascular system, they should not be used. A similar requirement is advanced to blood diseases. Some suppositories can not be used by children under the age of three months. Contraindications may differ slightly depending on the drug.

[9]

Side effects of suppositories on temperature

Side effects may appear for the first time after the drug is injected. These include allergic reactions that cause the suppository to become hot. This condition is typical for those cases when a person has inflammatory processes in the intestine, hemorrhoids and fissures in the anus. With the introduction of the suppository, burning, itching and general discomfort are noted. In this case, it is worth repealing the use of this method of treatment.

If the suppository has been introduced into the filled intestine, it can provoke its "work". In this case, the person feels the need to clean the intestines. Usually, together with feces, the suppository is removed. Re-enter it is not necessary, because it is unknown what part of the previous suppository had absorbed. It is fraught with an overdose.

Sometimes a suppository can lead to general malaise, weakness, headache and dizziness. Over time, it passes. It is likely that this is the body's response to this method of treatment. If the symptomatology does not disappear after two or three injections, you should cancel the medication and consult a doctor.

Overdose

The data on overdose is not fixed, but it is not necessary to exclude this process. It is necessary to mention once again that the suppository can cause a desire to cleanse the intestines from the temperature. In this case, the previously used suppository simply leaves it with feces. Therefore, many people inject the suppository again. This action is fraught with the development of negative reactions from the body.

There may be allergic reactions from the intestine. They usually pass on their own, but in some cases, an anus is required to be washed and the suppository removed. There may appear a metallic taste in the mouth, this is typical of Diclofenac, a general malaise and weakness.

If, for some reason, the suppository has entered the gastrointestinal tract, it is necessary to rinse. This will help to remove the suppository from the body and avoid poisoning. Treatment is symptomatic. Usually, the suppository does not cause an overdose, but the situations are different. In any case, it is necessary to remove the suppository from the body.

Interactions with other drugs

Drugs that can reduce body temperature should not be taken with induction of microsomal oxidation in the liver. In this case, we are talking about Flumecinol, Rifampicin, Ethanol and Phenytoin. They can lead to increased toxicity and lead to severe intoxication, even if there is a slight overdose. Therefore, the suppository should be taken with extreme caution in combination with other medicines.

Inhibitors of microsomal oxidation, such as cimetidine, can reduce the risk of developing hepatotoxic effects. With simultaneous use with salicylates, the likelihood of developing nephrotoxic action persists.

The use of suppositories together with paracetamol-based drugs can lead to increased toxic effects and overdose. Therefore, the suppository should be used only in a "pure" form. With simultaneous use with paracetamol, there is also an increase in the effect of anticoagulants of indirect action and a decrease in the effectiveness of uricosuric agents.

Storage conditions

When storing suppositories, the first thing to do is to observe the temperature regime. Many preparations show a temperature of not more than 25 degrees Celsius, but still, they are stored in the refrigerator. The composition of the suppository is such that they can quickly melt. Therefore it is desirable to place the suppository from the temperature in a cold place. Before use, they are simply removed and kept for 5 minutes at room temperature, after which they are injected into the anus.

Because of its ability to quickly melt, it is worth not only observe the temperature regime. It is necessary to avoid direct sunlight, dampness is also prohibited. Keep the suppository in the medicine cabinet is not recommended. It's worth putting them in a place where children do not get it, it could be the top shelves of the refrigerator. After all, kids can do harm to themselves and the medicine. Observing certain storage conditions, it is possible to guarantee the full service of the drug. If you ignore them, there is a risk of throwing the suppository ahead of time.

Shelf life

You can use the drug for 2 years. During all this period, special storage conditions must be observed. Many of the suppository from the temperature should be placed in the refrigerator, this will avoid their premature spoilage. The refrigerator will keep the suppository unchanged and reduce the risk of their melting and breaking.

As for all other medicines, the condition must be fulfilled: dry, dark and cold. No damp and direct sunlight should be. During the whole period of storage it is worth paying attention to the appearance of the drug. If the suppository is melted, it is not recommended to use them. After the expiration date, the reception is prohibited. At best, they will not give any effect, at worst will cause an allergic reaction from the body.

The color, odor, and consistency of the suppository should not vary. If the package was opened and the suppository is not used, it should not be used in the future. Proper storage will preserve all pharmacological properties of the drug.