Troychatka temperature

Even professional doctors call this tool universal “first aid” and recommend using it if your body temperature rises above 38 degrees. Triad on temperature helps to cope with SARS, influenza, inflammatory diseases.

Indications for use

In fact, this tool can always be used if an adult or a child has a fever due to an inflammatory process, a seasonal cold or flu. In addition, the triad on temperature is truly indispensable for other infectious diseases.

Today, there are many opinions about the effectiveness of this drug. Someone is considered his irreplaceable, and someone, on the contrary, thinks that it is more harmful than useful. In any case, if your body temperature rises to 38 degrees, do not rush to shoot it down. The fact is that thanks to her, the body creates a hot environment that does not like the pathogens. Malicious bacteria cease to multiply and immediately die if the patient's body temperature rises to 38.5 degrees. In addition, some drugs work more effectively only in this state of the body.

It is necessary to bring down the high temperature: with congenital and acquired heart defects, if you have frequent fainting or convulsions, arrhythmia, with neurotic or mental disorders (epilepsy).

Release form

Doctors call triad still lytic mixture. Usually use a solution for injection, but you can also drink and tablets. Lytic mixture means that this drug is a combination tool that helps to quickly stabilize normal body temperature. Also triad has an analgesic effect.

Pharmacodynamics

The classic version of the triad includes three main components: Analgin, No-spa, and diphenhydramine. Therefore, we consider the pharmacodynamics of each of them.

1. Analgin. It contains metamizole sodium, which is a derivative of pyrazolone. The drug has a weak antipyretic, analgesic, anti-inflammatory effect. Its mechanism is associated with the inhibition of the synthesis of PG (prostaglandins). 20-40 minutes after taking the drug, its pharmacological action develops. Maximum efficiency is achieved in two hours.
2. No shpa. The active active ingredient is drotaverine, which is derived from isoquinoline. It has a powerful antispasmodic action against smooth muscles due to inhibition of the enzyme phosphodiesterase. The latter is necessary for the hydrolysis of AMP and cAMP.[1]
3. Diazolin The drug is a blocker of H1-histamine receptors. Differs antiallergic action, helps reduce the swelling of mucous membranes. With this tool you can weaken the effect of histamine on smooth muscles, uterus, bronchi and intestines, reduce the severity of hypotension, increase the permeability of blood vessels. Slightly penetrates into the central nervous system, but it does not have a sedative or sedative effect. Anesthetic and M-cholinergic properties are poorly expressed. The effect is achieved in 15-30 minutes after administration. Its duration can last up to 2 days.[2]

Pharmacokinetics

Consider the pharmacokinetics of each drug, which is part of the classic recipe triad.

1. Analgin. Fully and rapidly absorbed immediately after ingestion. There is no unchanged metamizole in the blood. Remove the kidney drug. In this case, metabolites can be excreted along with breast milk. Completely excreted by urine.[3]
2. No shpa. Fully absorbed from the gastrointestinal tract after oral administration. But after metabolism at the first passage through the liver, 65% of the drug can enter the systemic circulation. After 45-60 minutes reaches the plasma.
3. Diazolin Due to the fact that the drug is rapidly absorbed through the gastrointestinal tract, diazolin immediately penetrates into the tissues of the body. Its bioavailability can range from 40% to 60%. The half-life of plasma lasts 4 hours. Through the blood-brain barrier hardly penetrates. Metabolism takes place in the liver. The drug is excreted by the kidneys.

The composition of the triad temperature

As mentioned above, triad on temperature is a combined drug. The classical composition of this tool includes: No-shpa (in particular, the component drovaterin), dimedrol and analgin. But today, most manufacturers are trying to replace Dimedrol (which can be bought only by prescription) with other antihistamines (Suprastin, Tavegil, Diazolin). In some cases, other components are replaced triad. For example, No-shpa is often replaced by Papaverine, which has a similar effect.

An interesting fact is that all the drugs that make up the triad, in fact, do not have the antipyretic effect, but together they help to bring the body temperature down to normal levels. Why it happens? These remedies help your immune system fight off bacteria. As a rule, when the temperature is high, the joints ache, the pulse quickens, and the head hurts. Troychatka with the help of its components, copes with these symptoms (analgin anesthesia, papaverine or no-spa will relieve vasospasm and expand them, diazolin - relieve swelling of tissues).

Troychatka temperature for children

Diseases that cause fever are not uncommon in both adults and children. Toddlers suffer from feverish condition worse. And, although many doctors do not recommend to bring the temperature down to 38 degrees, parents often do.

In such cases, triad is often used on temperature for children. In composition, it is no different from the classical (analgin, papaverine or no-spa, and any antihistamine). In what cases can such a drug be prescribed to a child and how safe is it?

Single intravenous doses of metamizol were well tolerated in more than 1,000 children under the age of 6 years. The likelihood of serious adverse reactions (hemodynamic, anaphylactic, or respiratory reactions) is less than 0.3%. Sample size and follow-up were insufficient to identify episodes of agranulocytosis.[5], [6]

Doctors often prescribe intramuscular administration of the triad in order to reduce high body temperature, regardless of what caused it (viral or bacterial infections). If you choose the right proportions, then a combination of three separate drugs will help to quickly stabilize the temperature, relieve pain in the joints, and overcome a headache. But, if you make an injection of a triad to a child, it should be remembered that during inflammatory processes it helps to take the temperature for only three to four hours, after which the heat appears again. Due to the strong load on the children's body, the triad can be administered no more than three times a day.

Remember, only a doctor can prescribe a triad on temperature, especially if there is a fever in young children. The danger lies in the fact that parents can choose the wrong dosage of drugs. If your child has a fever, you should immediately call a doctor and not self-medicate.

However, there are cases when a baby has a high body temperature, and it is not possible to call a specialist. To prevent the occurrence of seizures that can cause death, you must always keep in the first-aid kit a cooked triad or at least drugs that are part of it (in any form).

If your child is afraid of injections, the components of the triad can be made microclysmic, which will act in 5-10 minutes. But to abuse this tool is not worth it.

How is triad on temperature?

It should be understood that the triad is quite a serious tool that should not be entered into the body just like that. It is prescribed only in emergency cases when it is necessary to quickly bring down the temperature.

Recipes

Only a competent specialist can make the correct triad, which will help bring down the heat in your particular case. The fact is that the triad is made of three main components, which can be replaced by other drugs with a similar effect. For example, if Papaverine is not on hand, it can be replaced with Paracetamol and Diphenol with Suprastin or Diazolin. Analgin is easily replaced by any pain medication. Sometimes only a doctor can find effective means, especially when it comes to treating a child.

Dosage triad on temperature

First of all, you need to remember that the triad can only be used if the temperature has risen above 38 degrees. The injection will help to feel relief after 20 minutes, while taking the pills you will need to wait up to 40 minutes.

The dosage of the triad on the temperature always depends on the weight of the patient. If it is made up 55-60 kg, you can make the drug with 1 ml of Analgin, 1 ml of Diazolin and 1 ml of Papaverine (No-Shpy). If you decide to drink pills, you must carefully study the instructions for them.

Remember that after three to four hours the temperature will start to increase again, but triad can not be used more often than three times a day.

The method of applying triad on temperature

How to enter triad in the body?

1. Ampoules of three drugs need to squeeze in his hands to warm a little.
2. Disinfect the ampoules before the injection.
3. Using a disposable syringe, you must first enter 2 ml of Analgin, then 2 ml of Papaverine and 1 ml of allergy excipient (for example, Diazolin).
4. The best place for intramuscular injection is the outer upper square on the buttock. Treat the skin with alcohol in this place.
5. The needle should be inserted strictly perpendicular to the buttock.
6. Slowly inject the mixture when the game enters the skin at 2/3 of its length.

Using tablets is even easier. You just need to drink plenty of water each tablet separately.

The use of triad on temperature during pregnancy

During pregnancy and lactation can not take triad on the temperature. This is due to the fact that its composition includes Analgin. [4]In this case, you need to look for a suitable alternative. For example, the use of three different drugs in the form of tablets (Suprastin, No-Spa, and Baralgin) is excellent. It is also worth consulting a doctor who will prescribe an effective therapy that is safe for the health of the future mother and fetus.

Contraindications

In what cases you can not use a lytic mixture?

1. Cutting or wandering pain in the abdomen. This may be one of the symptoms of appendicitis.
2. Individual intolerance of at least one of the components of the triad.
3. If the patient has already taken any analogue of Analgin before the injection. This can lead to an overdose.
4. Pregnancy and lactation.

Overdose

An overdose of triad can occur only if four hours before the injection the patient had already taken a drug similar to Analgin.

Storage conditions

First of all, the triad must be kept out of the reach of small children. It should be dark, without direct sunlight. If you are not going to use the drug in the near future, you need to put in a cool place.

Shelf life

Typically, the shelf life of the triad on temperature is 2 years. Do not use the drug after the expiration of this period, as this may cause an unexpected reaction of the body and side effects.