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Zotek
Last reviewed: 23.04.2024
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Zotek is a drug from the group of NSAIDs, as well as an antirheumatic agent, methyl acetic acid derivative. The main active ingredient is dexibuprofen. The drug has antipyretic and analgesic activity.
The effect of the drug develops by slowing the production of GHG elements, which leads to inhibition of leukotriene binding, weakening of inflammatory puffiness (influenced by molimorphonuclear leukocytes), reduction of nitrous oxide formed, and reduction of oxidation of mitochondria affecting fatty acids.
Indications Zoteka
It is used to eliminate the signs of pain, having a light or moderate severity and a different nature. Among such pains affecting the joints, back or muscles, as well as rheumatic or toothache and dysmenorrhea.
Release form
The release of the drug is implemented in the form of tablets - 10 pieces inside the cell plate. In the box - 1 or 10 records.
Pharmacokinetics
The absorption of the drug is performed inside the small intestine. Blood substance Cmax substance reaches 120 minutes after oral administration of the drug.
Excretion of dexibuprofen from synovia occurs at low speed, because of which it is maintained at a stable level, regardless of plasma parameters of drugs.
Metabolic processes are realized inside the liver; non-active metabolic components are excreted through the kidneys (up to 90%), and another part is excreted through the intestinal lumen along with the bile.
The term half-life Zoteka equals 1.8-3.5 hours, synthesis with intraplasma protein is about 99%.
Taking the medication with food prolongs the term for achieving blood Cmax values from 2.1 to 2.8 hours, and also lowers plasma Cmax from 20.6 to 18.1 μg / ml, without affecting the degree of absorption.
Dosing and administration
The mode of use Zotek and its dosages are selected personally, taking into account the strength of the developing pains.
It is necessary to use 1-2 tablets for 1 use (0.2-0.4 g), 3 times a day after taking a meal. The initial portion should be 0.2 g of dexibuprofen. The total dosage per day (it is divided into 3 administrations) is equal to 0.6-0.9 g of the drug. For 1 reception, you can use no more than 0.4 g of drugs, and in general for the day - no more than 1.2 g.
With dysmenorrhea, the size of the maximum 1-fold portion is equal to 0.3 g, and the daily one is 0.9 g. Use the medicine with food.
The drug is used to eliminate the signs of pain; at the same time, if manifestations of the disease persist after 3+ days, and there are headaches, fever or other signs, they need to clarify the diagnosis and adjust the treatment scheme further.
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Use Zoteka during pregnancy
During the first 5 months of pregnancy, the use of the drug is not recommended. It is allowed to apply with strict indications and taking into account all the risks and benefits; enter it in the minimum portion and only for a short period. Starting from the 6th month, the use of drugs is completely prohibited.
The drug should not be given to women who are planning to conceive.
Dexibuprofen is able to stand out with mother's milk, which is why it is not used during breastfeeding. If Zotek is required, breastfeeding should be discontinued.
Contraindications
It is contraindicated to use the drug in case of severe intolerance against dexibuprofen or other NSAIDs and its other constituents; signs of hypersensitivity - bronchial spasm, an attack of asthma, an active phase of inflammation in the area of the nasal cavity or the development of polyps in the nose. In addition, the presence of a history of angioedema and urticaria is taken into account.
It can not be prescribed for bleeding inside the gastrointestinal tract or with other localization, and in addition with asthma, circulatory disorders, diathesis of hemorrhagic species and other coagulation disorders or with the use of anticoagulant treatment.
It is also not applied in case of lesions inside the gastrointestinal tract that are in the active phase, having an erosive-ulcerative nature, aggravated colitis of the ulcerative form of a non-specific character and granulomatous enteritis (active phase).
In addition, Zotek is not used for thrombocyte or leukopenia, disorders of the renal and hepatic activity (severe form), HF, diseases affecting the optic nerve, elevated blood pressure (malignant form) and color perception disorder.
Side effects Zoteka
The use of drugs can cause disturbances in the gastrointestinal tract, including nausea, abdominal pain, diarrhea, dyspepsia and vomiting; prolonged use can lead to ulcers inside the gastrointestinal tract with subsequent development of bleeding. At the same time, stomatitis with an ulcerative character may occur, and besides, occasionally, there is obstipation, nonspecific colitis of the ulcerous or hemorrhagic species, perforation inside the gastrointestinal tract, esophagitis, bloating, strictures of esophageal nature, and regional enteritis and diverticulitis in the active phase.
There may be lesions affecting the epidermis - urticaria, erythema multiforme, rashes and hyperemia (also allergic), and in addition TEN, itching, alopecia, SJS, photosensitization and allergic vasculitis.
Symptoms of intolerance to drugs are manifested in the form of headaches, asthma, shock or fever, runny nose, tachycardia, bronchial spasm, a decrease in blood pressure, and in addition, SLE, anaphylaxis, angioedema, and other collagen diseases.
CNS lesions - severe fatigue, anxiety, insomnia or drowsiness, dizziness, psychotic manifestations, visual hallucinations, and in addition, depression, double vision, irritability, ear ringing or noise, disorientation and meningitis of an aseptic variety.
Blood system disorders: prolongation of the blood coagulation period. Pancyto-, thrombocyto-, leuco- or granulocytopenia, anemia (hemolytic or aplastic) and agranulocytosis are rarely observed.
Lesions affecting the cardiovascular system: there may be an increase in blood pressure and signs of DOS or CHF (especially in the elderly). In individuals with elevated blood pressure or impaired renal activity, fluid excretion may be upset.
Urethral disorders - nephrotic syndrome or tubulointerstitial nephritis.
Taking into account the experience of using NSAIDs, we cannot exclude the possibility of the development of signs of liver or kidney failure.
The development of hyperhidrosis is rarely observed.
Overdose
Signs of poisoning include: stunned condition, headaches, nausea, pain in the peritoneal zone, dizziness, drowsiness, vomiting, ear ringing, nystagmus and ataxia, and in addition a decrease in blood pressure, bleeding inside the gastrointestinal tract, a decrease in temperature, impaired renal function and metabolic acidosis nature; single marked loss of consciousness.
The medication does not have an antidote; symptomatic measures are being taken. During the first hour after drinking the drug, gastric lavage with water can be performed. Also prescribed reception enterosorbents. The hemodialysis procedure will not be effective, because Zotek has a high level of protein synthesis.
Interactions with other drugs
It is forbidden to combine with other NSAIDs, because damage to the tissues inside the kidneys may develop, as a result of which signs of acute renal failure appear.
Caution is required when using the medication with other substances that increase the likelihood of bleeding inside the gastrointestinal tract, perforations and deterioration of the kidneys.
The introduction of drugs with any drug that slows down the activity of COX and the binding of PG, can lead to a disorder of fertility, therefore, this combination is not indicated for women planning to conceive.
The use of dexibuprofen and anticoagulants in pills or aspirin can cause prolonged blood coagulation and weaken platelet aggregation.
When using methotrexate in portions below 15 mg / kg, it is necessary during the first weeks of therapy to perform blood tests and monitor the work of the kidneys (especially in the elderly). With the introduction of methotrexate in a portion of more than 15 mg / kg, dexibuprofen should be used at least one day before. Increased plasma values of methotrexate, associated with the weakening of its renal excretion, enhances its toxic properties, because of which these substances are not used together.
Zotek can increase plasma indicators of lithium, reducing its renal excretion, so these drugs can not be combined.
It is extremely necessary to apply the drug with antihypertensive substances, because it weakens the drug effect of β-blockers.
Combining drugs with an ACE inhibitor or antagonists of angiotensin-2 endings can weaken the antihypertensive activity of the latter, and at the same time lead to the appearance of signs of ARF (especially in people who have a history of renal disorder, or in the elderly).
Tacrolimus with cyclosporine, when combined, can potentiate the likelihood of nephrotoxicity due to impaired renal PG binding. It is necessary to monitor the work of the kidneys, especially in the elderly.
GCS when combined with a drug can increase the risk of bleeding in the area of the gastrointestinal tract.
The introduction of the drug with digoxin leads to an increase in plasma parameters and the degree of toxicity of the latter.
The drug is able to replace phenytoin during protein synthesis, which can increase its blood values and enhance its toxic properties. Because of this, during the treatment you need to monitor the blood level of phenytoin.
Diuretic (including thiazide-like and thiazide, as well as potassium-sparing and loop) with a combination of NSAIDs increase the likelihood of kidney failure, as well as a secondary weakening of the renal blood flow.
Drugs that increase the performance of potassium, when combined with dexibuprofen, cause an increase in blood values of potassium, because of which you need to constantly monitor these indicators.
Ticlopidine with thrombolytic agents, as well as anti-platelet drugs, when combined with NSAIDs, can enhance anti-platelet activity.
Storage conditions
Zotek is required to keep in a closed place from small children. Temperatures - not more than 25 ° C.
Shelf life
Zotek can be used for a 24-month term from the time the medication is sold.
Attention!
To simplify the perception of information, this instruction for use of the drug "Zotek" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.