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Zotek
Last reviewed: 04.07.2025

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Zotek is a drug from the NSAID group, as well as an antirheumatic substance, a derivative of methylacetic acid. The main active component is dexibuprofen. The drug has antipyretic and analgesic activity.
The effect of the drug develops by slowing down the production of PG elements, which leads to inhibition of leukotriene binding processes, weakening of inflammatory edema (under the influence of molymorphonuclear leukocytes), a decrease in the volume of nitrous oxide formed, as well as a decrease in oxidation produced by mitochondria, affecting fatty acids.
Indications Zoteka
It is used to eliminate symptoms of pain of mild or moderate intensity and of various origins. Among these are pains affecting joints, back or muscles, as well as rheumatic or toothaches and dysmenorrhea.
Release form
The drug is released in the form of tablets - 10 pieces inside a cell plate. In a box - 1 or 10 plates.
Pharmacokinetics
The drug is absorbed in the small intestine. The substance reaches blood levels of Cmax after 120 minutes from the moment of oral administration of the drug.
Excretion of dexibuprofen from the synovium occurs at a low rate, due to which it is maintained at a stable level, regardless of plasma drug levels.
Metabolic processes are carried out inside the liver; inactive metabolic components are excreted through the kidneys (up to 90%), and another part is excreted through the intestinal lumen along with bile.
The half-life of Zotek is 1.8-3.5 hours, synthesis with intraplasmic protein is about 99%.
Taking the drug with food prolongs the time it takes to reach blood Cmax values from 2.1 to 2.8 hours and also reduces the plasma Cmax value from 20.6 to 18.1 mcg/ml, without affecting the degree of absorption.
Dosing and administration
The mode of use of Zotek and its dosage are selected individually, taking into account the strength of the developing pain.
You should take 1-2 tablets per application (0.2-0.4 g), 3 times a day after meals. The initial dose should be 0.2 g of dexibuprofen. The total daily dosage (divided into 3 administrations) is 0.6-0.9 g of the drug. No more than 0.4 g of the drug can be taken per administration, and no more than 1.2 g per day in total.
For dysmenorrhea, the maximum single dose is 0.3 g, and the daily dose is 0.9 g. The medicine should be taken with food.
The medication is used to eliminate the symptoms of pain syndrome; however, if the symptoms of the disease persist after 3+ days, and headaches, fever or other symptoms are observed against their background, it is necessary to clarify the diagnosis and additionally adjust the treatment regimen.
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Use Zoteka during pregnancy
It is not recommended to use the medicine during the first 5 months of pregnancy. It is allowed to use it under strict indications and taking into account all risks and benefits; it is administered in a minimal dose and only for a short period. Starting from the 6th month, taking the medicine is completely prohibited.
The medication should not be prescribed to women who are planning to conceive.
Dexibuprofen can be excreted in breast milk, which is why it is not used during breastfeeding. If the use of Zotek is required, breastfeeding should be discontinued.
Contraindications
The use of the drug is contraindicated in case of severe intolerance to dexibuprofen or other NSAIDs and its other components; signs of hypersensitivity - bronchial spasm, asthma attack, active phase of inflammation in the nasal cavity or development of polyps in the nose. In addition, the presence of Quincke's edema and urticaria in the anamnesis is taken into account.
It should not be prescribed for bleeding inside the gastrointestinal tract or in other locations, as well as for bronchial asthma, blood clotting disorders, hemorrhagic diathesis and other coagulation disorders, or when using anticoagulant treatment.
It is also not used in cases of active lesions of the gastrointestinal tract that are of an erosive and ulcerative nature, exacerbated ulcerative colitis of a non-specific nature and granulomatous enteritis (active phase).
In addition, Zotek is not used in cases of thrombocytopenia or leukopenia, renal and hepatic disorders (severe form), heart failure, diseases affecting the optic nerve, high blood pressure (malignant form) and color perception disorder.
Side effects Zoteka
The use of the drug may cause gastrointestinal disturbances, including nausea, abdominal pain, diarrhea, dyspepsia and vomiting; prolonged use may cause ulcers inside the gastrointestinal tract with subsequent bleeding. Along with this, stomatitis of an ulcerative nature may occur, and in addition, rarely, constipation, nonspecific colitis of an ulcerative or hemorrhagic variety, perforation inside the gastrointestinal tract, esophagitis, bloating, esophageal strictures, as well as regional enteritis and diverticulitis in the active phase are noted.
Lesions affecting the epidermis may also occur - urticaria, erythema multiforme, rashes and hyperemia (also allergic), as well as TEN, itching, alopecia, SJS, photosensitivity and vasculitis of allergic origin.
Symptoms of drug intolerance manifest themselves in the form of headaches, bronchial asthma, shock or fever, runny nose, tachycardia, bronchial spasm, decreased blood pressure, and in addition to this, SLE, anaphylaxis, Quincke's edema and other collagenoses.
CNS lesions include severe fatigue, anxiety, insomnia or drowsiness, dizziness, psychotic manifestations, visual hallucinations, as well as depression, double vision, irritability, tinnitus or noise, disorientation, and aseptic meningitis.
Blood system disorders: prolongation of the coagulation period. Rarely, pancyto-, thrombocyto-, leukopenia- or granulocytopenia, anemia (hemolytic or aplastic) and agranulocytosis are observed.
Lesions affecting the cardiovascular system: blood pressure may increase and signs of acute heart failure or chronic heart failure may occur (especially in the elderly). People with elevated blood pressure or impaired renal function may experience impaired fluid excretion.
Disorders associated with the urinary system - nephrotic syndrome or tubulointerstitial nephritis.
Taking into account the experience of using NSAIDs, the possibility of developing signs of liver or kidney failure cannot be ruled out.
The development of hyperhidrosis is observed sporadically.
Overdose
Signs of poisoning include: stupefaction, headaches, nausea, pain in the peritoneum, dizziness, drowsiness, vomiting, tinnitus, nystagmus and ataxia, as well as decreased blood pressure, bleeding in the gastrointestinal tract, decreased temperature, impaired renal function and metabolic acidosis; loss of consciousness is occasionally noted.
The drug has no antidote; symptomatic measures are taken. Gastric lavage with water can be performed within 1 hour after taking the drug. Enterosorbents are also prescribed. Hemodialysis will not be effective because Zotek has a high level of protein synthesis.
Interactions with other drugs
It is forbidden to combine with other NSAIDs, because it may cause tissue damage inside the kidneys, which will lead to signs of acute renal failure.
Caution is required when using the medication with other substances that increase the likelihood of bleeding inside the gastrointestinal tract, perforations and deterioration of kidney function.
The administration of the drug with any drug that inhibits COX activity and PG binding may lead to fertility disorders, so such a combination is not prescribed to women planning to conceive.
The use of dexibuprofen and anticoagulants in tablets or aspirin can cause prolongation of the blood clotting period and weakening of platelet aggregation.
When using methotrexate in doses below 15 mg/kg, blood tests and renal function monitoring (especially in elderly people) should be performed during the first weeks of therapy. When administering methotrexate in doses greater than 15 mg/kg, dexibuprofen should be used at least 24 hours before. Increased plasma levels of methotrexate, associated with decreased renal excretion, enhances its toxic properties, which is why these substances are not used together.
Zotek may increase plasma lithium levels by reducing its renal excretion, so these drugs should not be combined.
The drug should be used with extreme caution together with antihypertensive agents, because this weakens the medicinal effect of β-blockers.
Combination of drugs with ACE inhibitors or angiotensin-2 reuptake inhibitors may weaken the antihypertensive activity of the latter, and at the same time lead to the appearance of signs of acute renal failure (especially in individuals with a history of renal dysfunction or in the elderly).
Tacrolimus and cyclosporine when combined may potentiate the likelihood of nephrotoxicity due to weakened renal binding of PG. Renal function should be monitored, especially in the elderly.
GCS when combined with the drug may increase the risk of bleeding in the gastrointestinal tract.
The introduction of the drug with digoxin leads to an increase in plasma indices and the degree of toxicity of the latter.
The drug can replace phenytoin during protein synthesis, which can increase its blood levels and enhance its toxic properties. Because of this, blood levels of phenytoin should be monitored during therapy.
Diuretics (including thiazide-like and thiazide, as well as potassium-sparing and loop diuretics) when combined with NSAIDs increase the likelihood of renal failure, as well as secondary weakening of renal blood flow.
Potassium-elevating drugs, when combined with dexibuprofen, cause an increase in blood potassium levels, which is why these levels need to be monitored closely.
Ticlopidine with thrombolytics, as well as antiplatelet drugs when combined with NSAIDs, can enhance antiplatelet activity.
Storage conditions
Zotek should be stored in a place closed to small children. Temperature values are no more than 25°C.
Shelf life
Zotek can be used for a period of 24 months from the date of sale of the drug.
Attention!
To simplify the perception of information, this instruction for use of the drug "Zotek" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.