Zoflox

Zofloks is an antimicrobial therapeutic agent. It is a subcategory of fluoroquinolones and has a fairly extensive range of medicinal effects, helping to fight a variety of bacteria.

The drug shows a strong bactericidal effect on the human body. This is attributed to its ability to rapidly block the activity of a DNA gyrase enzyme that supports the activity of pathogenic microbes.

Indications Zofloksa

Used for such disorders:

• infection in the lower and upper urethra;
• lesions affecting the respiratory system;
• uncomplicated gonorrhea in the cervical area to the urethra;
• various infections of the joints, epidermis and soft tissues;
• cervicitis and urethritis with non-gonococcal etiology.

Release form

The release of drugs is sold in tablets - 10 or 5 pieces inside the plate; in the box - 1 record.

In addition, it is produced in the form of an infusion fluid - inside 0.1 l bottles; in a pack - 1 bottle.

[1]

Pharmacodynamics

The drug demonstrates the therapeutic activity of the Gram-negative subtypes: Shigella, Yersinia, the Morgans, the meningococcus acinetobacters and mycoplasmas. In addition, the drug acts on bacteria of the gram-positive subtype (streptococci with staphylococci).

Resistant to drugs have fecal enterococci, pseudomonads, pneumococci and anaerobes.

[2]

Pharmacokinetics

After taking the pill, the plasma level Cmax is noted already after 1-2 hours. In a solution, this value is noted after the introduction of approximately 60-minute infusion.

The bioavailability index is 95%. The drug can penetrate the placenta and excreted in the mother's milk. Indicators of intraplasma protein binding - about 25%.

Only a small part of the active component undergoes exchange processes. Basically, the drug is excreted unchanged - with feces and through the kidneys.

In people with renal or hepatic diseases, there may be a slowdown in the excretion of ofloxacin.

Dosing and administration

The use of pills.

The dosage scheme is selected by the attending doctor, taking into account the focus of infection, as well as the type of infection developed.

Portions for adults per day are usually in the range of 0.4-0.8 g.

With a daily dose of less than 0.4 g, it can be consumed in 1 administration. When dividing a serving into 2 uses, tablets are used after 12-hour time periods.

The medication is consumed for 0.5-1 hour before eating, washed down with ordinary water. The tablet does not raspusyvayut and do not divide.

The use of injections.

Injections should be carried out through an intravenous drip; infusion while continuing 0.5-1 hour. In one procedure, you can enter no more than 0.2 g of the substance. It is recommended to quickly transfer the patient to receive Zofloksa tablets.

For the day is allowed to enter no more than 0.8 g of ofloxacin.

Modes of drug use in various diseases:

• infection of the urinary system - the introduction of 0.2-0.4 g per day;
• diseases affecting the respiratory tract - 0.4 g per day;
• gonorrhea - 1-fold use of 0.4 g of the drug;
• cervicitis, urethritis and muscle lesions with soft tissues - 0.4 g of the substance is administered per day (divide the serving into 2 applications).

Typically, this therapy lasts 5-10 days. If a longer course is required, it can be a maximum of 2 months.

The introduction of the drug in case of problems with renal function.

The size of the dosage must be reduced. With indicators of QC in the range of 20-50 ml per minute, the dose of drug should be 0.1-0.2 g per day. If this figure is below 20 ml per minute, then it is necessary to administer 0.1 g of the drug per day.

Persons who undergo peritoneal or hemodialysis sessions should not be administered more than 0.1 g of the drug per day.

People who have marked hepatic diseases with severe severity should not be administered more than 0.4 g of drugs per day.

[3]

Use Zofloksa during pregnancy

You can not prescribe medication during pregnancy.

Contraindications

Among the contraindications:

• epilepsy;
• intolerance associated with drug elements or fluoroquinolone derivatives;
• reception by stroke survivors, head trauma or inflammation in the brain area, accompanied by a decrease in seizure threshold;
• tendonitis (also its presence in history);
• hypoglycemia, having an uncompensated form;
• combination with drugs incompatible with Zofloksom.

Side effects Zofloksa

The main adverse events associated with the use of drugs:

• hot flashes, photophobia, urticaria, epidermal rash, SJS, ulcers, nail bundle and epidermal pigmentation disorders;
• nephritis or kidney failure;
• hyperhidrosis, eczematous form of generalized pustules (in the active phase), erythema and pruritus;
• myopathy, muscle cramps or weakness, myalgia or tendonitis, as well as muscle breaks;
• anaphylactoid signs, vasculitis, anaphylaxis, dyspnea, eosinophilia, tachycardia, shock and fever;
• arrhythmia of the ventricles, prolongation of the QT-segment on the ECG, a decrease in blood pressure and collapse;
• agranulocytosis, neutro or leukopenia, and anemia;
• depression, tremor, dizziness, confusion, insomnia, headaches, convulsions, suicidal thoughts and agitation, as well as hallucinations, an increase in ICP and movement coordination disorders;
• auditory, visual or olfactory impairment, vertigo, eye irritation or ear noise;
• gastralgia, enterocolitis, nausea, bloating, disruption of intestinal flora, stomach pain and vomiting;
• allergic pneumonitis, bronchial spasms and nasopharyngitis;
• hepatitis, an increase in intrahepatic enzymes and jaundice;
• diabetics may develop hypo- or hyperglycemia;
• the emergence of a variety of infections of fungal nature, the development of candidiasis;
• fatigue or exacerbation of pathology may occur in individuals with porphyria.

Overdose

Signs of poisoning include gastric pain, vomiting, mucosal lesions in the gastrointestinal tract or nausea, and in addition, confusion, convulsions, dizziness, or nephritis.

After an overdose of less than 60 minutes, gastric lavage and symptomatic procedures can be performed. Also requires careful monitoring of cardiac function (ECG). Hemodialysis will have no effect.

Interactions with other drugs

The combination of drugs with sodium bicarbonate, citrates or carbonic anhydrase inhibitors increases the likelihood of nephrotoxicity and crystalluria.

The use of medication and antihypertensive drugs can cause a significant decrease in blood pressure.

Quinolones, among which ofloxacin, slow down the activity of the hemoprotein P450 structure. Because of this, it cannot be combined with theophylline, warfarin, cyclosporine, as well as methylxanthine and caffeine - because the term of their half-life will increase significantly.

Zofloks should not be administered with drugs that prolong the QT-segment - amiodarone, procainamide, macrolides, quinidine, tricyclics and sotalol.

The use of drugs and K-vitamin antagonists requires regular monitoring of the function of the blood coagulation system.

The combination of ofloxacin with NSAIDs, nitromidazole derivatives or methylxanthines increases the likelihood of renal complications and lowers the anticonvulsant threshold.

The gap between the use of the drug and antacids (Al, Fe, Mg, Ca, sucralfate, Zn) or multivitamins should be at least 2 hours.

The introduction together with insulin and other hypoglycemic substances can provoke hyper- or hypoglycemia.

The combination of the drug and methotrexate, furosemide, cimetidine or probenecid may increase its plasma values.

During the diagnosis of tuberculosis, as well as the detection of porphyrins or opiates inside the urine, in order to improve the accuracy of the analysis, it is necessary to temporarily discontinue the use of drugs.

[4]

Storage conditions

Zofloks is required to be kept in a place closed from sunlight, at standard temperature indicators for medicines.

Shelf life

Zoflox can be used for a 36-month term from the date of manufacture of the therapeutic agent.

[5]

Application for children

It is forbidden to use the drug in pediatrics.

Analogs

Analogues of the medication are the substances of Affitpro, Gatifloxacin, Abaktal, Levobact with Gatimak, Zolev with Avelox, and in addition Gatilin, Levasept, Moxin with Levofloxacin, Tsiprinol and Glevo. At the same time, Dasicon, Tsipprobel, Levoksimed, Tigeron and Moxifloxacin with Ciprofloxacin, as well as Norfloxacin and Sparfloxacin are on the list.

Reviews

Zoflox receives fairly good reviews from patients, but only when used in situations where the drug is prescribed by a doctor who previously tested the sensitivity of the pathogenic bacterium relative to the drug.

Of the minuses, the development of side effects, including nausea, loss of appetite, a decrease in blood pressure and the appearance of weakness, are distinguished. These manifestations often disappear after completion of the treatment cycle.

[6]