Zoflox

Zoflox is a drug with antimicrobial therapeutic activity. It belongs to the subcategory of fluoroquinolones and has a fairly wide range of medicinal effects, helping to fight a variety of bacteria.

The drug demonstrates a strong bactericidal effect on the human body. This is associated with its ability to quickly block the activity of the enzyme DNA gyrase, which maintains the activity of pathogenic microbes.

Indications Zoflox

It is used for the following disorders:

• infections in the lower and upper urethra;
• lesions affecting the respiratory system;
• uncomplicated gonorrhea in the area of the cervical canal with the urethra;
• various infections of joints, epidermis and soft tissues;
• cervicitis and urethritis of non-gonococcal etiology.

Release form

The drug is released in tablets - 10 or 5 pieces in a plate; in a box - 1 plate.

In addition, it is produced in the form of an infusion liquid - inside 0.1 l bottles; there is 1 bottle in a pack.

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Pharmacodynamics

The drug demonstrates therapeutic activity against gram-negative microbes: Shigella, Yersinia, Morgan bacteria, Meningococcus with Escherichia coli, Serratia, Legionella pneumophila with Klebsiella pneumoniae, Chlamydia, Serratia, Proteus, Haemophilus influenzae with Salmonella, Providencia, Klebsiella, Citrobacter with Gonococcus, Enterobacter, Acinetobacter and Mycoplasma. In addition, the drug also acts on gram-positive bacteria (Streptococcus with Staphylococcus).

Faecal enterococci, pseudomonads, pneumococci and anaerobes are resistant to drugs.

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Pharmacokinetics

After taking a tablet, the plasma level Cmax is noted after 1-2 hours. For a solution, this value is noted after the introduction of an approximately 60-minute infusion.

The bioavailability index is 95%. The drug can penetrate the placenta and be excreted with breast milk. The intraplasmic protein binding index is approximately 25%.

Only a small part of the active ingredient undergoes metabolic processes. The drug is mainly excreted unchanged - with feces and through the kidneys.

In people with kidney or liver disease, the excretion of ofloxacin may be slower.

Dosing and administration

Using tablets.

The dosage regimen is selected by the attending physician, taking into account the source of infection, as well as the type of infection that has developed.

Adult servings per day are typically in the range of 0.4-0.8 g.

If the daily dose is less than 0.4 g, it can be taken in 1 dose. When dividing the dose into 2 doses, the tablets are taken at 12-hour intervals.

The medicine is taken 0.5-1 hour before meals, washed down with plain water. The tablet is not chewed or divided.

Use of injections.

Injections should be given intravenously through a drip; the infusion lasts 0.5-1 hour. No more than 0.2 g of the substance can be administered in one procedure. In this case, it is recommended to transfer the patient to taking Zoflox in tablets as quickly as possible.

No more than 0.8 g of ofloxacin may be administered per day.

Modes of drug use for different diseases:

• urinary tract infections – administration of 0.2-0.4 g per day;
• diseases affecting the respiratory tract - 0.4 g per day;
• gonorrhea – 1-time use of 0.4 g of medication;
• cervicitis, urethritis and lesions of muscles and soft tissues - 0.4 g of the substance is administered per day (divide the dose into 2 applications).

Typically, such therapy lasts 5-10 days. If a longer course is required, it can be a maximum of 2 months.

Administration of medication in case of problems with kidney function.

The dosage size should be reduced. With CC values in the range of 20-50 ml per minute, the dose of the drug should be 0.1-0.2 g per day. If this value is below 20 ml per minute, then 0.1 g of the drug should be administered per day.

Persons undergoing peritoneal or hemodialysis sessions should not be administered more than 0.1 g of the drug per day.

People with severe liver disease should not take more than 0.4 g of the drug per day.

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Use Zoflox during pregnancy

The medication should not be prescribed during pregnancy.

Contraindications

Among the contraindications:

• epilepsy;
• intolerance associated with drug components or derivatives of fluoroquinolones;
• taken by people who have suffered a stroke, traumatic brain injury, or inflammation in the brain area accompanied by a decrease in the seizure threshold;
• tendonitis (also its presence in the anamnesis);
• hypoglycemia in an uncompensated form;
• combination with medications incompatible with Zofloxacin.

Side effects Zoflox

The main side effects associated with the use of drugs:

• hot flashes, photophobia, urticaria, epidermal rash, SJS, pustules, nail delamination and epidermal pigmentation disorders;
• nephritis or renal failure;
• hyperhidrosis, eczematous form of pustulosis of a generalized nature (in the active phase), erythema and itching;
• myopathy, muscle cramps or weakness, myalgia or tendinitis, and muscle tears;
• anaphylactoid signs, vasculitis, anaphylaxis, dyspnea, eosinophilia, tachycardia, shock and fever;
• ventricular arrhythmia, prolongation of the QT segment on the ECG, decreased blood pressure and collapse;
• agranulocytosis, neutro- or leukopenia, and anemia;
• depression, tremor, dizziness, confusion, insomnia, headaches, seizures, suicidal thoughts and agitation, as well as hallucinations, increased intracranial pressure and impaired motor coordination;
• auditory, visual, or olfactory disturbances, vertigo, eye irritation, or tinnitus;
• gastralgia, enterocolitis, nausea, bloating, intestinal flora disturbance, stomach pain and vomiting;
• pneumonitis of allergic origin, bronchial spasms and nasopharyngitis;
• hepatitis, increased intrahepatic enzyme levels and jaundice;
• Diabetics may develop hypo- or hyperglycemia;
• the emergence of various fungal infections, the development of candidiasis;
• People with porphyria may experience fatigue or an exacerbation of the pathology.

Overdose

Signs of poisoning include stomach pain, vomiting, damage to the mucous membranes in the gastrointestinal tract, or nausea, as well as confusion, convulsions, dizziness, or nephritis.

If less than 60 minutes have passed since the overdose, gastric lavage and symptomatic procedures can be performed. Careful monitoring of cardiac function (ECG) is also required. Hemodialysis will have no effect.

Interactions with other drugs

The combination of drugs with sodium bicarbonate, citrates or agents that inhibit carbonic anhydrase increases the likelihood of nephrotoxicity and crystalluria.

The use of medication and antihypertensive drugs can cause a significant decrease in blood pressure readings.

Quinolones, including ofloxacin, slow down the activity of the hemoprotein P450 structure. Because of this, it cannot be combined with theophylline, warfarin, cyclosporine, as well as methylxanthine and caffeine - because their half-life will increase significantly.

Zofloxacin should not be administered together with drugs that prolong the QT segment - amiodarone, procainamide, macrolides, quinidine, tricyclics and sotalol.

The use of drugs and vitamin K antagonists requires regular monitoring of the function of the blood coagulation system.

The combination of ofloxacin with NSAIDs, nitroimidazole derivatives or methylxanthines increases the likelihood of renal complications and lowers the anticonvulsant threshold.

The interval between taking the drug and antacids (Al, Fe, Mg, Ca, sucralfate, Zn) or multivitamins should be at least 2 hours.

Administration together with insulin and other hypoglycemic agents may cause hyper- or hypoglycemia.

The combination of the drug and methotrexate, furosemide, cimetidine or probenecid may increase its plasma levels.

During the diagnosis of tuberculosis, as well as when porphyrins or opiates are detected in the urine, in order to increase the accuracy of the analysis, it is necessary to temporarily stop using the drug.

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Storage conditions

Zoflox should be stored in a place protected from sunlight, at standard drug temperatures.

Shelf life

Zofloxacin can be used for a period of 36 months from the date of manufacture of the therapeutic agent.

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Application for children

The drug is prohibited for use in pediatrics.

Analogues

The analogs of the drug are the substances Ificipro, Gatifloxacin, Abaktal, Levobakt with Gatimak, Zolev with Avelox, and also Gatilin, Levasept, Moksin with Levofloxacin, Ciprinol and Glevo. Along with this, the list includes Dasikon, Ciprobel, Levoximed, Tigeron and Moxifloxacin with Ciprofloxacin, as well as Norfloxacin and Sparfloxacin.

Reviews

Zoflox receives fairly good reviews from patients, but only when used in situations where the medication is prescribed by a doctor who has previously tested the sensitivity of the causative bacteria to the medication.

The disadvantages include the development of side effects, including nausea, loss of appetite, decreased blood pressure, and weakness. These symptoms often disappear after the end of the treatment cycle.

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