Zodac

Zodak is a 2nd generation antiallergic drug with a prolonged type of therapeutic effect.

Indications Zodaca

It is used to eliminate the following disorders:

• hay fever;
• allergic conjunctivitis, as well as rhinitis (seasonal or year-round);
• an itchy form of dermatosis of allergic origin;
• urticaria (this includes the chronic stage of idiopathic urticaria);
• angioedema.

Release form

The medication is available in tablets, drops, and syrup.

The tablets are packaged in blister packs of 7 or 10 pieces.

The syrup is contained in glass bottles with a capacity of 100 ml. Inside the box there is 1 such bottle, which comes with a measuring spoon.

The drops are produced in glass bottles with a capacity of 20 ml. In addition to the bottle, the pack also contains a special dropper cap.

Pharmacodynamics

The active ingredient cetirizine is a component of a group of competitive histamine antagonists. The component helps block the endings of H1 histamine, and at the same time has virtually no cholinolytic or antiserotonin effect. It has a strong antiallergic effect, while also having an antipruritic and antiexudative effect.

The drug reduces the severity of allergy symptoms already at an early stage. In addition, it reduces the degree of movement of inflammatory cells. The drug suppresses the processes of secretion of conductors involved in the manifestation of late signs of allergy.

At the same time, cetirizine eliminates smooth muscle spasms and strengthens capillaries, thereby preventing tissue edema. It helps reduce the severity of skin reactions to the use of histamine and specific allergens, as well as to hypothermia (if cold urticaria develops).

Using the medication in a therapeutic dose does not cause a sedative effect and does not lead to a feeling of drowsiness.

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Pharmacokinetics

After taking drops, tablets or syrup, the active element is quickly absorbed from the gastrointestinal tract. The drug reaches peak values in the body 0.5-1 hour after administration.

Food intake has little effect on the extent of absorption, but taking the drug with food results in a slight decrease in the rate of absorption.

Synthesis with blood protein is about 93%. The drug does not penetrate into cells or through the BBB.

Metabolic processes take place inside the liver, resulting in the formation of inactive metabolic products.

When taking the drug in a 10 mg dose for 10 days, no accumulation of the active element inside the body is observed.

Most of the drug is excreted unchanged through the kidneys. After a single use of the drug, its half-life is about 10 hours. If the drug is taken by a child aged 2-12 years, the half-life of the substance decreases to 5-6 hours.

If the patient has problems with kidney function or if he undergoes hemodialysis procedures, the half-life is extended threefold, and the clearance rate is reduced by 70%.

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Dosing and administration

The medicine can be used only with the permission of a doctor - to avoid the development of complications. Zodak is used orally, and the medicine is not tied to food intake.

Scheme of use of medicinal tablets.

The tablets should be swallowed whole, then washed down with plain water. Teenagers over 12 years old, as well as adults, should take 1 tablet once a day.

The dose for children aged 6-12 years is 1 tablet per day - it is taken in 1 dose or in 2 doses (0.5 tablet in the morning and in the evening).

The portion sizes for elderly people are selected by the attending physician. Dose sizes for people with kidney disorders are also determined individually.

Syrup application mode.

Teenagers over 12 years of age and adults are prescribed a single dose of 2 measuring spoons of syrup per day.

Patients aged 6-12 years should take 2 measuring spoons of the medicine once a day or divide the dose into 2 doses - 1 spoon in the morning and then in the evening.

Children aged 2-6 years should be given 1 measuring spoon per day (in 1 dose or divided into 0.5 spoons in the morning and then in the evening).

People with kidney failure should reduce the dose by half. For elderly patients without kidney problems, no dose adjustment is required.

Mode of use of oral drops.

Before using the drops, they must be diluted in plain water. For adolescents from 12 years of age and adult patients, 20 drops of the drug are prescribed once a day. It is recommended to take the drug in the evening.

The age category for children aged 6-12 years requires the prescription of 20 drops once a day or 10 drops taken twice a day (in the morning and then in the evening).

Children aged 1-2 years should be given 5 drops of the medicine twice a day.

People with kidney failure need to reduce the dosage size of the drug by half.

Use Zodaca during pregnancy

Zodak should not be prescribed to nursing mothers or pregnant women.

Contraindications

Contraindication is severe intolerance to medicinal components.

The drug should be prescribed with caution to people with chronic kidney failure, as well as to the elderly.

Side effects Zodaca

The medication is usually tolerated without complications, although sometimes when using it, individual side effects occur, which is why the medication should be used with caution, following the instructions.

Possible adverse reactions include:

• digestive disorders: dry mouth and manifestations of dyspepsia;
• disorders of the nervous system: a feeling of excitement, fatigue, drowsiness, as well as dizziness, migraines and headaches;
• allergy symptoms: rashes, urticaria, and also Quincke's edema.

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Overdose

Due to drug poisoning, patients may develop the following negative symptoms: a feeling of drowsiness, as well as inhibition, weakness and severe fatigue. Tachycardia and headaches also occur. A feeling of irritability, constipation, dry mouth and delayed urination may occur.

To eliminate an overdose, symptomatic measures should be taken. The medication has no antidote. Gastric lavage is performed and activated charcoal is prescribed.

Interactions with other drugs

When the drug is used in combination with theophylline (in a dose of 0.4 g/day), a decrease in the overall clearance values of cetirizine is observed, while the pharmacokinetics of theophylline remains unchanged.

Cetirizine does not affect the processes of warfarin synthesis with blood proteins. In the case of such a combination, the absorption rate decreases, but its volume remains unchanged.

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Storage conditions

Zodak should be kept in a dry place, out of reach of children. Temperature indicators – within the range of 10-25°C.

Shelf life

Zodak can be used for 3 years from the date of release of the therapeutic agent.

Application for children

The medication in tablets can be prescribed to children over 6 years old, in syrup – to children over 2 years old, and drops – to infants over 1 year old.

Analogues

The following drugs are analogs of the drug: Zetrinal and Allertek with Alerza and Letizen, and in addition Cetirizine, Cetrin and Parlazin with Zyrtec and Zincet.

Reviews

Zodak receives mostly positive feedback from patients. Among its advantages, not only high efficiency in combating allergic symptoms, but also low cost are noted.

Parents who use the medicine to treat their children speak positively about the drug in the form of drops. Taking the drops is very convenient, and there are no side effects when using them.

Regarding the tablets, many positive reviews are left by people who have suffered from allergic manifestations for many years. They say that the tablets helped to significantly improve their health at the stages of exacerbation of the pathology.