Since the drug contains 2 active substances (zidovudine with lamivudine), it is able to interact in accordance with the characteristics of both of them.
In the case of a combination of a drug with myelosuppressive or nephrotoxic drugs (among these, the systemic use of pentamidine with pyrimethamine, and in addition to this dapsone, flucytosine, co-trimoxazole and interferon, as well as amphotericin B, ganciclovir with doxorubicin, and vinblastine with vincristine) requires continuous monitoring of hematological level and renal function. Dosage is lowered if necessary.
It is required to monitor the indices in the blood of the phenytoin substance - when combined with Zidolam.
Codeine with aspirin and morphine, and in addition oxazepam with ketoprofen, indomethacin with naproxen and cimetidine, as well as dapsone with oxazepam and isoprinosine are able to influence the metabolism of zidovudine (competingly slowing the formation of its glucuronide or directly suppressing the metabolism of the substance with microsomal hepatic enzymes) .
Probenecid can increase zidovudine, suppressing the process of glucuronization or reducing the rate of excretion of the substance through the kidneys.
The use of fluconazole influences metabolic processes and the clearance factor of zidovudine.
Valproic acid slows the 1 st phase of hepatic metabolism of zidovudine, which increases the bioavailability of the latter. Because of this, when combined use of these substances is recommended to monitor the health of patients in order to promptly reveal the increase in the negative reactions to the use of zidovudine.
Separate nucleoside analog drugs can affect the work, as well as the number of white blood cells / erythrocytes, can enhance the toxic properties of zidovudine relative to blood cells, and in addition to this DNA replication process.
Ribavirin antagonizes the antiviral activity of zidovudine relative to the HIV virus (in vitro).
Substances pyrimethamine, trimethoprim, and also acyclovir with sulfamethoxazole are allowed to be used in the process of prevention or treatment of infectious processes provoked by conditionally pathogenic organisms, because with limited use of these drugs their toxic properties are not enhanced.