Zevesin

The drug Zevesin belongs to the pharmacological group of urological agents. Manufacturer - Zentiva (Czech Republic). Names of synonymous drugs: Solifenacin, Vesikar; analogues include: Urotol (Detruzitol), Driptan (Dream-Apo, Sibutin, Novitropan) and Spazmex.

Indications marshmallow

The drug Zevesin is used in clinical urology for the treatment of incontinence (urinary incontinence), in particular, involuntary urine leakage due to overactive bladder, which manifests itself as sudden, unbearable (urgent) urge to urinate.

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Release form

Zevesin: film-coated tablets of 5 and 10 mg.

Pharmacodynamics

The pharmacological action of the drug Zevesin is provided by the active substance - the tertiary amine solifenacin succinate, which is a specific blocker (inhibitor) of m-cholinergic receptors.

Solifenacin affects the endings of parasympathetic nerve fibers - muscarinic acetylcholine receptors of the ejection muscle of the bladder wall (detrusor), as a result of which the increased tone of the smooth muscles of the bladder decreases to physiological. Thus, the therapeutic effect of the drug Zevesin is to restore normal neuromuscular functioning of the bladder and stop involuntary urination.

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Pharmacokinetics

After oral administration, Zevesin is absorbed in the gastrointestinal tract and enters the systemic bloodstream. The bioavailability of solifenacin succinate is almost 90%.

It binds to blood plasma proteins (almost 98%), the maximum plasma concentration of the active substance is observed 3-8 hours after application.

85% of Zevesin undergoes biotransformation by the liver isoenzyme CYP3A4. One of the metabolites (4R-hydroxy-solifenacin) is active, which contributes to a longer therapeutic effect of the drug.

The active substance is excreted from the body through the kidneys (69%) and intestines. The half-life is 45-68 hours.

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Dosing and administration

Zevesin is taken orally - one tablet (5 mg) once a day, washed down with a glass of water. Taking the drug does not depend on food intake. If necessary, the attending physician can increase the daily dose to 10 mg.

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Use marshmallow during pregnancy

Due to the lack of sufficient clinical studies, use during pregnancy and lactation also requires caution.

Contraindications

Contraindications to the use of Zevesin include: hypersensitivity to solifenacin, urinary tract obstruction, chronic gastrointestinal tract pathologies, colon hypertrophy (megacolon), weakness of striated muscles (myasthenia), severe renal and/or hepatic failure, closed-angle glaucoma, hemodialysis, childhood, congenital galactose intolerance, glucose-galactose malabsorption, as well as treatment with active inhibitors of cytochrome CYP3A4.

In patients with gastrointestinal obstruction and low motility, hiatal hernia, gastroesophageal reflux, prolonged QT syndrome and low blood potassium levels (hypokalemia), Zevesin should be administered with great caution.

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Side effects marshmallow

Zevesin may cause side effects that most often manifest as: dry mouth, nasal passages and mucous membranes of the eyes, constipation, accommodation disorders, urinary retention, urticaria, angioedema, liver dysfunction, increased drowsiness, confusion and the occurrence of hallucinations.

It is also possible that nausea and vomiting, swelling in the legs, pain in the stomach, etc. may occur.

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Overdose

Overdose of this drug causes more intense manifestation of its side effects. In such cases, it is necessary to use activated carbon, gastric lavage and symptomatic treatment.

Interactions with other drugs

The drug Zevesin, interaction with other drugs blocking m-cholinergic receptors, increases the likelihood of unwanted side effects.

The simultaneous use of antifungal agents that block liver enzymes – Miconazole, Ketoconazole, Itraconazole and other triazole derivatives – contributes to an increase in the concentration of Zevesin in blood plasma.

Zevesin reduces the therapeutic effect of antiemetic drugs used in gastroenterology (Metoclopramide hydrochloride, Cerucal, Regastrol), as well as Peristil (Cisapride) used in the treatment of intestinal dyskinesia.

In order to avoid creating an increased risk of complications, Zevesin should not be prescribed together with drugs from the group of selective calcium channel inhibitors (Verapamil, Veracard, etc.).

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Storage conditions

Store Zevesin: at a temperature not exceeding +25°C.

Shelf life

Shelf life: 36 months.

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