Zeusin

The drug Zeusin is part of the pharmacological group of urological agents. Manufacturer - Zentiva (Czech Republic). Names of drugs-synonyms: Solifenacin, Vesicar; to analogs are: Urotol (Detruzitol), Driptan (Dream-Apo, Sibutin, Novitropan) and Spazmex.

Indications of the eaves

Zevesin is used in clinical urology for the treatment of incontinence (urinary incontinence), in particular, involuntary discharge of urine with bladder hyperactivity, which is manifested by sudden intolerable (urge) urge to urinate.

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Release form

Zeusin: tablets in a film coat of 5 and 10 mg.

Pharmacodynamics

Pharmacological action of the drug Zeusin provides the active substance - tertiary amine solifenacin succinate, which is a specific blocker (inhibitor) of m-cholinergic receptors.

Solifenacin affects the endings of parasympathetic nerve fibers - muscarinic acetylcholine receptors of the expelling muscle of the bladder wall (detrusor), resulting in an increased tone of the smooth muscles of the bladder decreases to physiological. Thus, the therapeutic effect of Zevesin's drug is to restore normal neuromuscular function of the bladder and stop involuntary urination.

[3], [4], [5], [6]

Pharmacokinetics

After ingestion, Zevesin is absorbed into the digestive tract and enters the systemic circulation. The bioavailability of solifenacin succinate is almost 90%.

It binds to blood plasma proteins (almost 98%), the maximum plasma concentration of the active substance is noted in 3-8 hours after application.

85% of Zeusin is biotransformed with the isoenzyme of the liver CYP3A4. One of the metabolites (4R-hydroxy-solifenacin) is active, which contributes to a longer therapeutic effect of the drug.

The active substance is excreted through the kidneys (69%) and the intestines. The half-life period is 45-68 hours.

[7], [8], [9], [10], [11]

Dosing and administration

Zeusin is taken orally - once a day, one tablet (5 mg), which should be washed down with a glass of water. The intake of the drug does not depend on the intake of food. If necessary, the attending physician can increase the daily dose to 10 mg.

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Use of the eaves during pregnancy

Because of the lack of sufficient clinical studies, use during pregnancy and lactation also requires caution.

Contraindications

Contraindications to the use of Zevesin include: increased sensitivity to solifenacin, obstruction of the urinary tract, chronic pathologies of the gastrointestinal tract, hypertrophy of the large intestine (megacolon), weakness of the striated muscle (myasthenia), severe kidney and / or liver failure, glaucoma of the closed type, hemodialysis , children's age, congenital intolerance to galactose, glucose-galactose malabsorption, as well as treatment with active inhibitors of cytochrome CYP3A4.

In the presence of gastrointestinal obstruction and its low motor skills, chi hernia, gastroesophageal reflux, QT interval prolongation syndrome and reduced potassium level in the blood (hypokalemia), Zevesin should be administered with great care.

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Side effects of the eaves

Zeusin can cause such side effects, which are most often manifested in the form of: dry mouth, nasal passages and mucous eyes, constipation, accommodation disorders, urine retention, urticaria, angioedema, liver dysfunction, increased drowsiness, confusion and hallucinations .

Also, the possibility of nausea and vomiting, edema on the legs, pain in the stomach, etc., is not ruled out.

[14], [15], [16]

Overdose

Overdose of this drug causes a more intense manifestation of its side effects. In such cases it is necessary to use activated carbon, gastric lavage and symptomatic treatment.

Interactions with other drugs

The drug Zeusin, interaction with other drugs-blockers of m-holinoretseptorov, increases the likelihood of manifestations of undesirable side effects.

The simultaneous use of antimycotic agents blocking hepatic enzymes - Miconazole, ketoconazole, Itraconazole and other triazole derivatives, contributes to the increase in Zevesin concentration in the blood plasma.

Zevesin reduces the therapeutic effect of anti-emetics used in gastroenterology (Metoclopramide hydrochloride, Cerucal, Regastrol), and also used in the treatment of dyskinesia intestinal Peristila (Cisapride).

In order not to create an increased risk of complications, it is not possible to prescribe Zevesin together with the drugs of the group of selective inhibitors of calcium channels (Verapamil, Veracard, etc.).

[19], [20], [21], [22], [23]

Storage conditions

Store Zeusin: at a temperature of not more than + 25 ° C.

Shelf life

Shelf life - 36 months.

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