The drug has a prolonged effect, which allows it to provide a full-fledged antibacterial course after ingestion of a single dosage of drugs. Thanks to the information that was obtained after the testing of pharmacokinetics (with the participation of volunteers), it became known that the peak of serum concentration and AUC (in comparison with standard drugs with immediate release properties) it reaches immediately on the day of single administration of granules with azithromycin.
The relative bioavailability index of the drug is 83%, and the peak of the serum concentration of the substance reaches later by almost 2.5 hours.
With the use of the drug along with food, volunteers who took 2 grams of medicine immediately after a meal that contained a large amount of fats showed an increase in plasma peak and AUC levels by 115%, and 23%, respectively. With the use of drugs by volunteers after taking regular food, the peak of plasma indicators increased by 119%, while the AUC indices remained unchanged.
According to clinical tests, it can be concluded that azithromycin powder has better tolerability in the case of fasting.
Synthesis with plasma protein depends on the level of concentration and decreases by 51% in the case of 0.02 μg / ml, as well as by 7% in the case of 2 μg / ml. The distribution of matter occurs inside all tissues, the equilibrium state of the distribution volume is 31.1 l / kg.
Tissue values of azithromycin exceed its level in serum with plasma. The extensive distribution of drugs across tissues can provoke its drug activity. The antimicrobial effect of the component depends on the pH. It is likely that it is weakened by a decrease in this indicator.
The main part of the active substance is excreted with bile, in unmodified form.
Serum azithromycin values after a single dose (2 g) were reduced in accordance with the polyphase model, and the final half-life is 59 hours. Such a prolonged period of final half-life is most likely associated with an expanded distributional volume.
Biliary excretion (as a rule, unchanged) is considered the main way of excretion. For 7 days, about 6% of the dosage used can be detected as an unchanged substance in the urine.