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Zefasel
Last reviewed: 23.04.2024
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Zephasel is a medicine that helps to fill the lack of selenium inside the body.
Indications of the zefasel
It is used in case of diagnosed deficiency of the level of selenium inside the body, which appears due to malnutrition or as a result of disorders of digestive function or absorption. Used when there is no way to compensate for this condition with a special diet.
In combination therapy, Cephasel is used for oncological diseases, digestive system diseases and CVS, and in addition, in conditions of respiratory and rheumatic conditions, as well as in the thyroid gland.
However, the drug is prescribed in case of intoxication with heavy metals, and at the same time breastfeeding or pregnant women, under stress and high physical exertion, and in addition to the elderly and people who abuse alcohol and smoking.
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Release form
The release is made in tablets, in the amount of 20 pieces inside the package.
Pharmacodynamics
Zephasel is a medicine that contains selenium, which is one of the most important microelements for the human body. It interacts with enzymes, biological membranes, as well as vitamins, participates in carbohydrate, fat and protein metabolism, and besides it helps to regulate oxidation-reduction processes.
Inside the blood plasma, selenium, acquiring the amino acid form of selenocysteine, is synthesized with the selenoprotein P component (this is the protein that transports selenium), and in addition with glutathione peroxidase (it is an important part of the protective system of cells of the antioxidant type).
There is a relationship between the values of selenium inside the plasma, and in addition the potential risk of oncological pathologies, thyroid disease and disorders in the work of CCC (such as myocardial infarction, arteriosclerosis, and in addition cardiomyopathy).
In people with kidney failure and diseases inside the digestive tract, there is a decrease in plasma parameters of selenium.
Pharmacokinetics
The absorption of sodium selenite after ingestion occurs mainly within the 12-intestine. Inside the bloodstream, selenium is assimilated by erythrocytes, and continues as a conversion to hydrogen selenide (with the participation of the enzyme system).
Hydrogen selenide within the body becomes the main place of storage of selenium, being there prior to the stage of formation of combined ligaments with selenoprotein or to excretion of the excess of this trace element from the body. Excess hydrogen selenide passes the process of metabolic changes with the help of dimethylselenide elements, as well as methylselenol, resulting in the formation of trimethylsilene ions (they are the main excretory products).
The cumulative number of selenium within the body varies in the range of 4-20 mg, and the excretion of this substance is determined by its internal content, and at the same time the amount of this component consumed from the outside (for example, together with food).
Excretion of selenium occurs through the kidneys with the intestine, and at the same time in the form of the ions of trimethylselene and other metabolic products with the help of the lungs.
Dosing and administration
Tablets should be consumed after eating - swallowing whole and squeezed with plain water.
Often, treatment begins with the use of 1 tablet of drugs (100 mcg), once a day. If required, for a short period of time, it is allowed to increase the daily portion to 300 μg.
You need to take the medicine until the moment when the recovery of natural selenium values occurs - within the whole blood they make 100-140 ng / ml, and inside the blood plasma - about 80-120 ng / ml.
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Use of the zefasel during pregnancy
Cephasel is permitted for use by pregnant women and nursing mothers. In some situations, its use is even recommended by doctors.
Contraindications
Among the contraindications - the presence of intolerance against selenium or excessively high its indices inside the body. Also, medicine in the form of tablets is forbidden to prescribe to children, although in itself selenium in childhood is allowed to use.
Side effects of the zefasel
In certain situations, patients develop symptoms of hypersensitivity.
Overdose
In acute intoxication, the patient experiences nausea, diarrhea similar to garlic from the mouth, fatigue, and abdominal pain. The systematic poisoning by Cephasel causes the growth of nails with hair, and at the same time the appearance of signs of polyneuropathy.
To eliminate acute intoxication, it is necessary to cleanse the intestinal tract, as well as perform symptomatic procedures. When chronic poisoning is required to reduce the size of a portion of selenium or completely abandon its use.
Storage conditions
Cephasel can be kept in the usual conditions for medicines.
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Shelf life
Zephasel can be used for 5 years from the date of release of the drug.
Reviews
Zephasel does not have enough objective and reliable reviews about its medicamental effects. This is due to the fact that the diagnosis of a lack of any trace element (and other necessary components) inside the body requires preliminary passage of various tests and examinations - in order to correctly select the required drug.
But while on the Internet you can often find articles of an advertising nature, often with incomplete or generally erroneous information on the impact of drugs and its effectiveness. We should not expect that taking Cephasel will solve almost any problems with the function of SSS, as well as with the organs of the digestive tract and thyroid gland (which is often indicated in similar articles). Selenium is indeed an important element necessary for the body, but it does not alone affect the stable functioning of all its organs and systems. Therefore, before using the drug, you must first understand the causes that caused the development of the disorder.
Upon receipt of confirmation that the problem is precisely the lack of selenium, the appointment of Cephasel will be quite appropriate and appropriate. In this case, its use will help to eliminate the disorder and stabilize the state of health.
Attention!
To simplify the perception of information, this instruction for use of the drug "Zefasel" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.