Medical expert of the article
New publications
Preparations
Zatrin
Last reviewed: 03.07.2025

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Zatrin is an antibacterial agent for systemic use, belongs to the group of macrolide antibiotics. ATC code - J01F A10. Manufacturer - FDC Limited (India). Other trade names: Azithromycin, Azitrox, Sumamed, Sumametsin, Sumamox, Zitrolide, Zitrocin, Hemomycin.
Indications Zatrin
Zatrin is used in otolaryngology for the treatment of pharyngitis, tonsillitis, sinusitis, bronchitis, otitis, and pneumonia caused by bacterial infections; in dermatology, for the treatment of erysipelas, impetigo, pyoderma (including staphylococcal sycosis), ecthyma, and bacterial balanitis; in urology, for the treatment of urethritis, chlamydial cervicitis, and colpitis.
Release form
Zatrin is available in 500 mg tablet form.
Pharmacodynamics
The mechanism of bactericidal action of the drug Zatrin is provided by its active substance - the antibiotic azithromycin. It penetrates into the lysosomes of prokaryotes and neutralizes the enzymes of the large subunit of the cellular ribosome (50S), catalyzing the reaction of transpeptidation. As a result, the assembly of polypeptide chains of proteins in bacterial cells ceases, binding to matrix RNA becomes impossible, and thus the process of bacterial reproduction stops.
Zatrin is active against gram-positive aerobes (Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes), gram-negative aerobes (Haemophilus, Legionella pneumophila, Moraxella catarrhalis) and anaerobic bacteria (Clostridium perfringens, Fusobacterium, Prevotella).
Pharmacokinetics
After oral administration, Zatrin is quickly adsorbed in the gastrointestinal tract and enters the blood. However, the drug binds insignificantly to plasma proteins, entering mainly into tissues. The highest serum concentration of the drug is observed on average 2.5 hours after administration; the bioavailability of the active substance is about 37%.
More than 85% of the drug undergoes biotransformation in the liver (by demethylation and hydroxylation) with the formation of inactive metabolites. The rest is excreted unchanged by the kidneys. Excretion occurs by the intestines and kidneys.
The elimination of the active substance from plasma lasts up to 20 hours, from tissues – up to 24-72 hours, therefore Zatrin is taken once every 24 hours.
Use Zatrin during pregnancy
Use during pregnancy is not recommended.
Contraindications
Contraindications to the use of Zatrin are individual hypersensitivity to antibiotics of this group, as well as severe liver and kidney dysfunction.
[ 9 ]
Side effects Zatrin
The use of Zatrin may cause nausea, vomiting, diarrhea, flatulence, abdominal cramps, dizziness and increased fatigue, allergic reactions (skin rashes and itching), reversible visual impairment, distortion or loss of taste and smell. Among the rarer possible side effects of this drug are oral and vaginal candidiasis, eosinophilia, leukopenia, psychomotor hyperactivity, palpitations and chest pain, decreased liver and kidney function, and joint pain.
As with other antibacterial drugs, there is a possibility of superinfection (mycoses) and changes in the normal flora of the colon with increased growth of Clostridium difficil strains.
Interactions with other drugs
The bioavailability of Zatrin is reduced when taken simultaneously with antacids (drugs for the treatment of heartburn in acid-dependent gastrointestinal diseases).
Zatrin should be combined with caution with other macrolide antibiotics, in particular, cyclosporine derivatives. Levomycetin (chloramphenicol) and tetracyclines enhance the effectiveness of Zatrin, while lincomycin and clindamycin weaken it.
Taking indirect anticoagulants (warfarin), as well as coumarin oral anticoagulants, may increase the risk of bleeding when using Zatrin. The simultaneous use of Zatrin and heparin is incompatible.
Storage conditions
Store at temperatures below +25°C.
[ 18 ]
Shelf life
36 months.
Attention!
To simplify the perception of information, this instruction for use of the drug "Zatrin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.