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Zanocin
Last reviewed: 03.07.2025

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A broad-spectrum antibacterial drug, Zanocin, produced by the Indian corporation Ranbaxy Laboratories Ltd. The active ingredient, ofloxacin (ofloxacinum), has a destructive effect on the DNA gyrase of the cell of pathogenic microorganisms, blocking their ability to self-reproduce.
Infection. This word has become so deeply ingrained in our lives that it no longer scares us. “I caught an infection, took a pill, and it went away,” many people think. This is fundamentally wrong. Pathogenic microflora is capable of destroying our body from the inside, even to the point of death. And this may well happen if measures are not taken in time. The effective antibacterial drug Zanocin was created by a team of doctors and pharmacists to block the DNA genome of pathogenic flora cells, destroying it. Thereby ridding the patient of the cause of his infection. The drug Zanocin will allow you to forget forever about such an inconvenient and dangerous neighbor as infectious diseases of various genesis.
Indications Zanocin
Some of the most common diseases are infectious diseases caused by pathogenic flora. Hence the indications for the use of Zanocin:
- Gynecological infections:
- Gonorrhea.
- Chlamydia.
- Postpartum infections.
- And others.
- Urinary tract diseases. Infectious pathology of chronic or severe manifestation.
- Cystitis (inflammation of the mucous membrane of the bladder).
- Epididymitis is an inflammation of the epididymis in the stronger half of the population.
- Prostatitis (inflammation of the prostate gland) is the most common pathology in men.
- Hydronephritis is a disease whose basic symptom is the developing expansion of the renal pelvis.
- Treatment of recurrent infectious diseases.
- And others.
- Infection of the upper and lower respiratory tract by microorganisms belonging to gram-positive cocci.
- A venereal infection. The causative agents of the disease are chlamydia, gonococci and other microorganisms resistant to the penicillin group of drugs.
- Inflammation of the pelvic organs caused by mixed infection.
- Damage to ENT organs.
- Various types of sinusitis (inflammation of one or more paranasal sinuses).
- Otitis (an inflammatory process occurring in the auricle).
- Tonsillitis (inflammatory process in the palatine tonsils).
- And others.
- Infectious lesion of the gastrointestinal tract, including bacterial dysentery.
- Dermatological infection:
- Erysipelas (or erysipelas of the skin).
- Impetigo is a skin disease characterized by the formation of superficial vesicular-pustular rashes.
- Cellulite.
- And others.
- Infection of wounds during surgical intervention.
- Endocryst (inflammation of the inner lining of the heart).
- Abdominal infections.
- Septicemia (blood poisoning).
- Central nervous system damage.
- Preventive measures to prevent the progression of infection.
- Osteomyelitis (a purulent-necrotic process developing in the bone and bone marrow).
- Conjunctivitis.
That is, the indications for the use of Zanocin are quite extensive and cover a significant area of localization of infectious lesions.
Release form
The manufacturing company releases two varieties of the Zanocin “product” onto the pharmaceutical market.
Release form:
- Tablets in a package of 10 pieces. Each tablet is film-coated and contains 200 mg of the active substance ofloxacin.
- In the form of solutions that are usually used for droppers.
Pharmacodynamics
The antibacterial action of the active element ofloxacin is expressed in its ability to destroy the structure of bacterial enzymes, blocking their ability to self-reproduce. That is, the pharmacodynamics of Zanocin comes down to disrupting the normal functioning of the DNA of pathogenic microflora.
The following bacteria respond well to the main active compound of the drug Zanocin: Staphylococcus aureus, Proteus spp., Neisseria meningitidis, Vibrio parahaemolyticus, Escherichia coli, Klebsiella pneumoniae, Aeromonas hydrophila, Vibrio сholerae, Citrobacter spp., Plesiomonas, Yersinia spp., Haemophilus influenzae, Salmonella spp., Chlamydia trachomatis, Enterobacter aerogenes, Shigella spp., Neisseria gonorrhoeae, Campylobacter jejuni, Staphylococcus epidermidis, Legionella pneumophila.
Less sensitive bacteria include the following strains: Mycobacterium tuberculosis, Enterococcus, Serratia marcescens, Streptococcus Mycoplasma pneumoniae, Mycobacterium fortuitum, Mycoplasma hominis, Pseudomonas aeruginosa. Clostridium difficile, Fusobacterium, Bacteroides, Clostridium difficile, Peptococcus, Acinetobacter, Peptostreptococcus, Eubacterium, Treponema pallidum, Nocardia asteroides, Ureaplasma urealyticum.
Pharmacokinetics
There is a linear dependence of the level of ofloxacin in the blood plasma on the dose taken (in concentrations from 200 to 600 mg), that is, the greater the amount of the drug introduced into the patient's body, the higher its level in the blood. Its maximum amount is achieved when the drug is administered in a dosage of 2 to 5 mcg / ml. At the same time, the pharmacokinetics of Zanocin is highly active, which allows the components of the drug to be absorbed by the mucous membrane of the gastrointestinal tract as quickly as possible. Food intake does not affect the absorption capacity of Zanocin, it can only slightly slow it down. The degree of penetration of ofloxacin into solid tissues and liquid is from 1.0 to 2.5 liters per kilogram of human weight.
Most of Zanocin is excreted from the patient's body through the kidneys along with urine. When taking ofloxacin at a dosage of 100 mg once, after four hours in the urine, during laboratory tests, the concentration of the drug shows a figure of 155 mcg / ml. A day later, the test result shows more than 10 mcg / ml. The half-life of ofloxacin corresponds to six hours. Approximately five percent leaves the human body as metabolites along with urine and only four to eight percent is excreted with feces.
Since the maximum elimination of the drug occurs through the kidneys, these parameters change significantly in patients with problems with the functioning of this organ, or in patients who have crossed the age threshold of 65 - 85 years. The half-life is extended to 13 - 14 hours.
Dosing and administration
The treatment protocol using the drug Zanocin is prescribed strictly individually. The method of administration and doses depend on many factors: the type of infectious agent, its location, the severity of the disease, the patient's age, the patient's weight and the adequacy of kidney function.
Pills:
- If an infection in the intestines and urinary tract is diagnosed, the drug is administered twice a day at 200 mg of Zanocin.
- In acute, severe cases of gonorrhea, the doctor prescribes a single dose of 400 mg of the drug.
- When differentiating chlamydia, the medicine is taken for seven to ten days, twice a day, 300 to 400 mg ofloxacin.
- If inflammation of the prostate in a man is caused by a strain of E. coli, the course of treatment can last up to six weeks, with the drug Zanocin prescribed at 300 mg twice a day.
- The drug Zanocin is taken twice a day at 200–400 mg in case of infection of various or mixed etiologies.
A solution that is administered intravenously, by infusion, or by drip:
- In case of infection of the bladder and urinary tract, a drip of 200 mg is administered twice a day.
- In case of respiratory tract infection, the drug is administered twice a day in an amount of 200 to 400 mg of the drug (depending on the overall clinical picture of the disease and the patient's well-being).
After the patient’s condition has normalized, the medication should be continued for another two to three days to “consolidate” the effect achieved.
In case of renal function pathology, the dosage of ofloxacin is reduced taking into account the degree of damage.
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Use Zanocin during pregnancy
Based on the high level and rate of penetration of ofloxacin into all tissues and fluids of the human body, the use of Zanocin during pregnancy and lactation is contraindicated, since the fetus or newborn child also receives a high dose of the drug along with breast milk, which negatively affects his health. In case of vital necessity, the question of using the drug Zanocin can only be decided by the attending physician. If the introduction of the drug is necessary, then it is worthwhile to refuse breastfeeding for this time.
Contraindications
This medicine does not belong to particularly toxic compounds, but there are still contraindications to the use of Zanocin:
- Individual intolerance to the constituent components.
- It is not recommended for use in treating children under 12 years of age.
Side effects Zanocin
The drug in question is quite effective in the treatment of infectious diseases of various genesis, but when taking it, side effects of Zanocin may appear, such as:
- Anorexia, loss of appetite.
- Headaches.
- Skin rashes.
- Nausea, less often vomiting.
- General loss of strength and dizziness.
- Swelling and shortness of breath.
- A short-term drop in blood pressure.
- Diarrhea.
- The patient feels discomfort in the stomach area.
- Eye irritation caused by sunlight.
- Itching and rashes on the skin surface.
- Sleep disturbances, anxiety.
- Fever.
- Unsteady gait and tremor (due to pathology of muscle coordination).
- Visual impairment.
- Quite rarely, but cases of tachycardia are known.
- Anemia.
- Thrombocytopenia.
- Vaginal candidiasis.
- Lowering blood sugar levels.
- Pain in muscles and joints.
- If the patient has a history of a predisposition to porphyria, the chemical compound ofloxacin can provoke its development.
Overdose
To date, there is little material on cases where an overdose of the drug in question was observed. Its symptoms can be voiced in several points.
- Unsteadiness of consciousness.
- Slowness in movement, speech and thoughts.
- Nausea, less often leading to vomiting.
- Dizziness and general weakness.
- Minor disorientation in space.
It should be noted right away that there is no single antidote to the symptoms of Zanocin overdose at the present stage. Therefore, eliminating the consequences of taking a large amount of the drug comes down to some successive stages.
- Gastric lavage.
- Taking adsorbent drugs.
- If possible, sodium sulfate should be taken within half an hour after an overdose.
- To protect the gastric mucosa from irritation, the patient should be given antacid drugs.
- Hydration of the body is possible (administration of special solutions that replenish fluid loss).
- Taking diuretics allows ofloxacin to be eliminated from the body more quickly.
Interactions with other drugs
It is necessary to be quite careful with any combinations of different drugs. Not knowing their mutual influence on each other can lead not only to a decrease in their effective work, but also cause serious harm to the patient's health.
Therefore, in the case of complex treatment, it is necessary to clearly understand which interactions of Zanocin with other drugs can increase the positive effect of drugs on the body, and which ones should not be taken together.
For example, antacids block or significantly reduce the ability of ofloxacin to be absorbed into the blood. Their combined use should be avoided.
With drugs containing aluminum, magnesium, sucralfate, iron or zinc, it is better to spread out the intake of Zanocin over time. Ofloxacin should be administered to the patient two hours after taking "antagonist" drugs. Ofloxacin, as a fluoroquinolone, should be carefully administered with drugs of a similar group, as this can lead to an increase in the concentration of theophylline in the plasma.
The drugs methotrexate and furosemide contribute to a significant slowdown in the process of removing ofloxacin from the body. Caution is also needed in tandem use with non-steroidal anti-inflammatory drugs, as they enhance the effect of Zanocin on the central nervous system.
It is necessary to constantly monitor the coagulation level in case of taking the drug in question with warfarin. Monitoring of glycemic parameters is important in case of combined administration of ofloxacin with antidiabetic drugs (such as insulin or glibenclamide).
Storage conditions
The developer and manufacturer of this medicine recommends the following storage conditions for Zanocin:
- The storage location should be protected from direct sunlight and moisture.
- Where it should be accessible to children.
- The temperature at which the medicine is stored should not be higher than 25 o C.
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Shelf life
The shelf life is three years (36 months). The date of manufacture and the final expiration date must be indicated on the packaging. If the expiration date of the medicine has expired, further use of the drug is not recommended.
Attention!
To simplify the perception of information, this instruction for use of the drug "Zanocin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.