Zanotsin

Antibacterial drug of a wide spectrum of action - Zanocin - manufactured by the Indian corporation Ranbaxy Laboratories Ltd. The active active ingredient ofloxacin (ofloxacinum) destructively affects the DNA-gyrase of cells of pathogenic microorganisms, blocking their ability to self-reproduce.  

Infection. This word became so dense in our life that it stopped us from frightening. "I picked up the infection, drank a pill, and everything went away," many people think. This is fundamentally wrong. The pathogenic microflora is capable of destroying our body from the inside, right up to a lethal outcome. And this may well happen if the time is not taken. The effective antibacterial drug Zanocin was created by a team of doctors and pharmacists in order to block the DNA of the cells of the pathogenic flora, destroying it. Thus, relieving the patient of the cause of his defeat. The drug Zanocin will give an opportunity to forget forever about such an inconvenient and dangerous neighbor as infectious diseases of various genesis.

Indications of the zanotsin

One of the most common diseases is infectious diseases, the pathogens are caused by pathogenic flora. Hence the indications for Zanocin:

• Infections of gynecological localization:

• Gonorrhea.
• Chlamydia.
• Postpartum infection.
• And others.

• Diseases of the urinary tract. Infectious pathology of chronic or severe manifestation.

• Cystitis (inflammation of the mucous membrane of the bladder).
• Epididymitis is an inflammation of the epididymis of the representatives of a strong half of the population.
• Prostatitis (inflammation of the prostate gland) is the most common pathology in men.
• Hydronephritis is a disease, the basic symptom of which is the developing expansion of the bowl-and-pelvic system of the kidney.
• Treatment of relapses of infectious diseases.
• And others.

• The defeat of the upper and lower respiratory tract by microorganisms belonging to Gram-positive cocci.
• Venereal infection. The causative agents of the disease are chlamys, gonococci and other microorganisms resistant to the penicillin group of drugs.
• Inflammation of the pelvic organs caused by a mixed infection.
• Lesion of ENT organs.

• Various kinds of sinusitis (inflammation of one or several paranasal sinuses).
• Otitis (an inflammatory process that occurs in the auricle).
• Tonsilitis (inflammatory process in the tonsils).
• And others.

• Infectious lesions of the gastrointestinal tract, including bacterial dysentery.
• Dermatological infection:

• Erysipelas (or erysipelas of the skin).
• Impetigo is a skin disease characterized by the formation of superficial blister-pustular eruptions.
• Cellulite.
• And others.

• Infection of wounds during surgery.
• Endocraditis (inflammation of the inner shell of the heart).
• Infections of the abdominal cavity.
• Septicemia (blood poisoning).
• The defeat of the central nervous system.
• Preventive measures to prevent the progression of infection.
• Osteomyelitis (purulent-necrotic process, developing in the bone and bone marrow).
• Conjunctivitis.

That is, the indications for the use of Zanocin are quite extensive and cover a significant area of localization of infectious lesions.

Release form

The manufacturer produces two varieties of "product" Zanocin on the pharmacological market.

Form of issue:

• Tablets in a package of 10 pieces. Each tablet is film-coated and contains 200 mg of ofloxacin.
• In the form of solutions, which are usually used for droppers.

Pharmacodynamics

The antibacterial action of the active element ofloxacin is expressed in its ability to destroy the structure of bacterial enzymes, blocking their ability to self-replicate. That is, the pharmacodynamics of Zanocin reduces to the disruption of the normal functioning of the pathogenic microflora DNA.

Zanocin, the main active compound of the Zanocin preparation, reacts to such bacteria as Staphylococcus aureus, Proteus spp., Neisseria meningitidis, Vibrio parahaemolyticus, Escherichia coli, Klebsiella pneumoniae, Aeromonas hydrophila, Vibrio cholerae, Citrobacter spp., Plesiomonas, Yersinia spp., Haemophilus influenzae, Salmonella spp., Chlamydia trachomatis, Enterobacter aerogenes, Shigella spp., Neisseria gonorrhoeae, Campylobacter jejuni, Staphylococcus epidermidis, Legionella pneumophila.

To less sensitive bacteria include such strains: Mycobacterium tuberculosis, Enterococcus, Serratia marcescens, Streptococcus Mycoplasma pneumoniae, Mycobacterium fortuitum, Mycoplasma hominis, Pseudomonas aeruginosa. Clostridium difficile, Fusobacterium, Bacteroides, Clostridium difficile, Peptococcus, Acinetobacter, Peptostreptococcus, Eubacterium, Treponema pallidum, Nocardia asteroides, Ureaplasma urealyticum.

Pharmacokinetics

A linear dependence of the level of ofloxacin in the blood plasma on the dosage taken (in concentrations from 200 to 600 mg) is seen, that is, the more medication is injected into the patient's body, the higher its level in the blood. The maximum amount is achieved when the drug is administered in a dosage of 2 to 5 μg / ml. Moreover, the pharmacokinetics of Zanocin is characterized by high activity, which allows the constituents of the drug to be absorbed as quickly as possible by the mucosa of the gastrointestinal tract. Food intake does not affect Zanotsin's absorption abilities, she can only slow down a little. Stepan's level of penetration of ofloxacin into solid tissues and liquid is from 1.0 to 2.5 liters per kilogram of human body weight.

Most of Zanocin is excreted from the body of the patient through the kidneys along with the urine. When taking ofloxacin in a dosage of 100 mg once, after four hours in urine, when carrying out laboratory tests, the concentration of the drug shows a figure of 155 μg / ml. After a day, the test result shows more than 10 μg / ml. The half-life of ofloxacin is six hours. Approximately five percent leaves the human body as metabolites along with urine and only four to eight percent are excreted with feces.

Due to the fact that the maximum elimination of the drug occurs through the kidneys, these parameters change significantly in patients who have problems with the functioning of this organ, or in patients who have crossed the age threshold of 65 to 85 years. The half-life period is extended to 13 - 14 hours. 

Dosing and administration

The protocol of treatment with the use of Zanocin is prescribed exclusively individually. The method of application and dose depend on many factors: the type of pathogen, the location of its infection, the severity of the disease, the patient's age, the weight of the patient and the adequacy of the kidneys.

Pills:

• If an infection in the intestine and urinary tract is diagnosed, then the drug is administered twice daily for 200 mg of Zanocin.
• In the case of acute, severe cases of gonorrhea, the doctor attributes the medication once in a dosage of 400 mg.
• When differentiating chlamydia, the drug is taken for seven to ten days, 300 to 400 mg of ofloxacin twice daily.
• If the inflammation of the prostate in a man is caused by a strain of E.coli, the course of treatment can take up to six weeks, with the drug Zanocin attributed to 300 mg twice daily.
• Twice a day 200-400 mg are taken with Zanocin in case of infection of a diverse or mixed etiology.

The solution, which is administered intravenously, infusional, drip:

• With infection of the bladder and urine-withdrawing canals, a dropper is placed twice a day for 200 mg.
• In case of infection by the respiratory tract infection, the drug is administered twice a day in an amount of 200 to 400 mg of the drug (depending on the overall clinical picture of the disease and the patient's well-being).

After normalization of the patient's condition, continue taking the medication for two to three days to "fix" the effect.

In the pathology of renal function, the dosage of ofloxacin is reduced taking into account the degree of their defeat.

[1]

Use of the zanotsin during pregnancy

Based on the high level and rate of penetration of ofloxacin into all tissues and fluids of the human body, the use of Zanocin during pregnancy and during lactation is contraindicated, since the fetus or newborn baby, along with breast milk, also receives a high dose of medication, which negatively affects his health . In case of vital necessity, the question of using Zanocin's medicine can only be decided by the attending physician. If the administration of the drug is necessary, it is worthwhile at this time to refuse breastfeeding.

Contraindications

This medicine does not apply to particularly toxic compounds, but there are contraindications to the use of Zanocin:

• Individual intolerance of constituent components.
• It is not recommended to use in the treatment of children under 12 years of age.

Side effects of the zanotsin

This drug is quite effective in the treatment of infectious diseases of various genesis, but when it is taken, Zanocin's side effects may appear, such as:

• Anorexia, loss of appetite.
• Headache.
• Skin rashes.
• Nausea, less often - vomiting.
• General decline of strength and dizziness.
• Puffiness and shortness of breath.
• Short-term drop in blood pressure.
• Diarrhea.
• The patient does not feel comfortable in the stomach.
• Cutting in the eyes, the cause of which is sunlight.
• Itching and eruptions on the skin surface.
• Violation during sleep, anxiety.
• Fever.
• Unstable gait and tremor (caused by the pathology of muscle coordination).
• Vision disorders.
• Rarely, but cases of tachycardia are known.
• Anemia.
• Thrombocytopenia.
• Vaginal candidiasis.
• Reducing blood sugar levels.
• Pain in the muscles and joints.
• If a history of the patient is predisposed in the manifestation of porphyria, the chemical compound ofloxacin is capable of provoking its development.

Overdose

To date, quite a bit of material about cases when there was an overdose of the drug in question. Its symptoms can be voiced at several points.

• Uncertainty of consciousness.
• Drowsiness in movements, speech and thoughts.
• Nausea, less likely to vomit.
• Dizziness and general weakness.
• Slight disorientation in space.

It is necessary to make a reservation at once that there is no single antidote to the symptomatology of Zanocin overdose at the present stage. Therefore, the elimination of the consequences of taking a large amount of the drug is reduced to some successive stages.

1. Gastric lavage.
2. Admission of adsorbing drugs.
3. If possible, within half an hour after an overdose, it is necessary to take sodium sulfate.
4. To protect the gastric mucosa from irritation, it is necessary to administer antacids to the patient.
5. Possible hydration of the body (the introduction of special solutions that make up the liquid loss).
6. The adopted diuretics allow forloxacin to be quickly removed from the body.

Interactions with other drugs

Carefully enough, it refers to any combination of different drugs. Not knowing their mutual influence on each other can lead not only to a decrease in their effective work, but also to bring a serious harm to the health of the patient.

Therefore, in case of complex treatment, it is necessary to clearly understand which interactions of Zanocin with other drugs are capable of increasing the positive effect of drugs on the body, and which ones should not be taken together better.

For example, antacids are blocked or significantly reduced the ability of ofloxacin to be absorbed into the blood. Their joint use should be avoided.

With preparations containing aluminum, magnesium, sucralfate, iron or zinc, Zanocin is better for taking the medicine in time. Ofloxacin is to be injected into the patient's body two hours after taking antagonist drugs. Ofloxacin, like fluoroquinolone, should be gently administered with preparations of a similar group, as this may lead to an increase in the concentration of theophylline in the plasma.

Methotrexate and furosemide drugs contribute significantly to inhibition ofloxacin elimination from the body. Care must also be taken in tandem with non-steroidal anti-inflammatory substances, as they increase the effect of Zanocin on the central nervous system.

It is necessary to constantly monitor the level of coagulation in the case of taking the drug in question with warfarin . It is important to monitor glycemic parameters in the case of combined use of ofloxacin with antidiabetic drugs (such as insulin or glibenclamide). 

[2], [3]

Storage conditions

The company developer and manufacturer of this drug recommends such storage conditions Zanocin:

• The storage place must be protected from direct sunlight and moisture.
• De should be available for children.
• The temperature at which the medication is stored, should not be higher than 25 ^for AS

[4]

Shelf life

Shelf life is three years (36 months). At the same time, the date of issue and the deadline for implementation are mandatory on the packaging. If the expiration date of the medicinal product has expired, further use of the drug is not recommended.