Zalasta q-tab

Zalasta q-tab is a drug designed to achieve a clinical effect in schizophrenia. It is taken mainly by adults to improve the mental state and maintain normal human life.

Indications Zalasta q-tab

Indications for use of Zalast q-tab - schizophrenia. This medicine is used exclusively by adults. Its main focus is to maintain the clinical effect during long-term therapy in patients. Especially in those who have responded to initial therapy.

The drug is also used for moderate and severe manic episodes. The medication is also widely used to prevent recurrent manic episodes in patients with bipolar disorder. Especially if a positive result was obtained during olanzapine therapy.

This medicine should not be given to children. Any violations of this kind in this case should be eliminated in another way. The child's body is not able to tolerate the active effect of the drug on itself.

The medicine is used exclusively on the doctor's recommendations. In case the initial therapy has given a positive result, and favorable changes are observed. Treatment Zalasta q-tab is really effective.

Release form

The drug is available in tablet form. The active ingredient is olanzapine. One tablet contains 5 mg, 7.5 mg, 10 mg, 15 mg or 20 mg. Naturally, there are also auxiliary components, such as mannitol (E421), crospovidone, aspartame (E 951), microcrystalline cellulose, low-substituted hydroxypropyl cellulose, magnesium stearate and calcium silicate.

The tablets are completely dispersed in the oral cavity. One package contains 4 or 8 blisters. Each of them contains 7 tablets. On average, the medication is packaged in 28 or 56 tablets per package. This is convenient if the therapy is long-term.

The medicine is easy to use. Due to its softness, the tablet should be removed carefully and immediately placed on the tongue. It begins to disintegrate in a matter of seconds and thus guarantees a quick effect. The product immediately penetrates the mucous membrane of the mouth and salivary glands into the body. Today, Zalasta q-tab is a truly powerful remedy in the fight against attacks of schizophrenia.

Pharmacodynamics

Pharmacodynamics Zalasta q-tab - the active substance is olanzapine. It is a neuroleptic, antimanic and mood-stabilizing drug, demonstrating a wide pharmacological profile in many receptor systems. Due to its rapid reaction, the drug has become especially widespread. It is enough to simply remove the tablet and put it on the tongue. The result will be available in a matter of seconds.

Olanzapine has a broad affinity (Ki < 100 nM) for serotonin receptors 5 HT2A / 2C, 5 HT3, 5HT6, dopamine D1, D2, D3, D4, D5, cholinergic muscarinic receptors ml-m5, α1-adrenergic receptors and histamine H1 receptors. All this confirms the true ability of the drug to combat even the most difficult cases.

Olanzapine has shown greater affinity in vitro for serotonin 5HT2 than for dopamine D2 receptors, and greater potency for 5HT2 than D2 in in vivo models. Zalasta q-tab is a potent agent in the treatment of schizophrenia attacks.

Pharmacokinetics

Pharmacokinetics Zalasta q-tab - tablets that quickly disperse in the oral cavity. The main component of the drug is absorbed immediately after oral administration. Its maximum concentration in plasma is achieved within 5-8 hours. Food intake does not affect absorption in any way.

Absolute oral bioavailability relative to bioavailability after administration has not been determined. The drug is metabolized in the liver via conjugative and oxidative pathways. The main circulating metabolite is 1 0-N-glucuronide. It does not cross the blood-brain barrier. Cytochromes P450-CYP1A2 and P450-CYP2D6 are involved in the formation of N-desmethyl and 2-hydroxymethyl metabolites.

As for clearance, it is significantly lower in elderly people compared to young people. A similar situation is observed in women compared to men, and in those who smoke compared to those who have given up this harmful habit.

The active component binds to plasma proteins by approximately 93% over the entire concentration range from approximately 7 to approximately 1000 ng/ml. In general, the main binding occurs with albumin and α1-acid glycoprotein. This is the pharmacokinetics of the drug Zalasta q-tab.

Dosing and administration

The method of application and dosage are discussed individually with the attending physician. The tablets are able to disperse quickly in the oral cavity. Therefore, they are fragile in their physical properties. This indicates that the product must be carefully removed from the blister and immediately placed in the oral cavity. Do not use water, the tablet quickly disintegrates.

The recommended starting dose for people with schizophrenia is 10 mg per day. For manic syndrome, it is 15 mg in monotherapy and 10 mg in combination therapy. To prevent relapse, 10 mg per day is used. The dose can be adjusted according to the individual clinical condition of the person in the range of 5-20 mg per day.

For elderly patients, the dosage is not reduced, it is also 10 mg per day. In case of impaired renal and hepatic function, it is advisable to use 5 mg of the drug. In this case, the dosage is increased with special caution. Zalasta q-tab should be taken according to the individual characteristics of the body and based on the problem that needs to be eliminated.

Use Zalasta q-tab during pregnancy

The use of Zalast q-tab during pregnancy is a separate issue. Thus, adequate and well-controlled studies regarding the effect of the drug on the body of a woman and a child during this period are absent.

Experience in treating pregnant women with this medication is limited. Therefore, it is not recommended to resort to this remedy during this period. Naturally, a comparison should always be made. The positive effect for a woman should be significantly higher than the negative impact on the developing organism. Only in this case is the intake appropriate.

Children whose mothers used this product in the third trimester are at risk of developing adverse reactions. Including extrapyramidal disorders and/or withdrawal syndrome, the symptoms of which may vary in strength and duration. There have been cases of hypertension, tremor, drowsiness and feeding disorders. Therefore, the child's condition should be carefully monitored.

Healthy women who breastfed their babies and took the drug at the same time did not notice any negative effects. Naturally, the active component penetrates into milk. The average safe dose for the baby is 1.8% of the maternal dose. However, it is not recommended to take Zalasta q-tab during pregnancy and breastfeeding.

Contraindications

Contraindications to the use of Zalast q-tab - increased hypersensitivity to active substances. In this case, it is highly undesirable to use the medication. This can lead to a serious allergic reaction from the body. A similar situation occurs if a person has hypersensitivity to any inactive ingredient of the drug. That is why it is extremely important to consult a doctor about treatment.

If certain rules are not followed, there is a risk of developing closed-angle glaucoma. This will lead to a deterioration in the condition. More severe consequences may develop. The body is capable of reacting to this medication in a peculiar way. Especially if some of its components cause an allergic reaction. This indicates that the best way to avoid harm is to consult a doctor. Zalasta q-tab is an effective remedy that must be taken after consultation with a specialist to avoid the development of side effects.

Side effects Zalasta q-tab

Side effects of Zalast q-tab make up a whole list. Thus, they can arise against the background of the body's rejection of the main component or auxiliary substances. Naturally, cases of a significant excess of the dose are not excluded, which will lead to the appearance of negative reactions from many organs and systems.

The following side effects were particularly common: drowsiness, increased cholesterol and glucose levels, improved appetite, dizziness, dyskinesia, asymptomatic increases in liver transaminases, rashes, edema, and fatigue.

From the side of the circulatory system, the development of leukopenia, thrombocytopenia, neutropenia and eosinophilia cannot be excluded. The immune system is capable of responding with a powerful allergic reaction. From the side of the digestive organs, weight gain, development or exacerbation of diabetes and hypothermia cannot be excluded.

The nervous system may react with drowsiness, parkinsonism, dizziness, epileptic seizures, lethargy and akathisia. From the cardiovascular system, bradycardia, ventricular tachycardia and even sudden death are possible.

On the part of the liver and biliary tract - asymptomatic increase in the level of liver transaminases ALT and AST. This is typical for the beginning of treatment. Peripheral edema and hepatitis are not excluded.

On the skin side - photosensitivity reaction and alopecia. The musculoskeletal system can react with rhabdomyolysis and arthralgia. On the kidney side - urinary retention, difficulty urinating and even urinary incontinence are possible.

From the reproductive system: erectile dysfunction in men, decreased libido in women and men, breast enlargement and priapism. All these side effects can be caused by incorrect or improper use of the drug Zalasta q-tab.

Overdose

An overdose of the drug is not excluded. This occurs mainly due to a sharp increase in the dosage used or in the presence of hypersensitivity to some components of the drug.

The main symptoms of an overdose are: agitation, aggression, tachycardia, decreased consciousness, and even coma. There are other adverse reactions that are less common. These are mainly delirium, coma, seizures, respiratory depression, hypertension, and cardiopulmonary shock. A fatal outcome occurs with a dose of 450 mg. There have been cases where people survived even after 2 grams of the drug.

If signs of overdose appear, it is necessary to provide assistance to the person. There is no specific antidote to the drug. It is advisable to induce vomiting in the person by regular gastric lavage. It is not worth taking special drugs that can cause this reaction.

According to the clinical condition, symptomatic treatment and monitoring of vital organ function should be initiated. This includes treatment of arterial hypotension and collapse, and respiratory functions are supported. Dopamine, epinephrine and other sympathomimetics with beta-agonist action should never be used. They can complicate arterial hypotension. Zalasta q-tab, if taken incorrectly, can lead to serious consequences.

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Interactions with other drugs

Interactions of Zalasta q-tab with other drugs are possible, but with special caution. Thus, the metabolism of the drug can be affected by inhibitors or inducers of cytochrome P450 isoforms, especially the activity of CYP1A2.

Smoking and carbamazepine intake may decrease olanzapine concentrations and thus lead to complete ineffectiveness. In some cases, a slight to moderate increase in olanzapine clearance has been noted.

The drug is not able to change the pharmacokinetics of theophylline. Fluoxamine, in turn, can reduce the ability of olanzapine to metabolize. This can lead to an average increase in the maximum concentration in the plasma of fluoxamine by 54%, and in male smokers by 77%. Patients taking fluoxamine should use olanzapine in a reduced dose.

Activated carbon reduces the oral bioavailability of olanzapine by 50-60%. Therefore, it should be taken 2 hours before or after olanzapine.

CYP2D6 inhibitors. Fluoxetine causes a mean increase in olanzapine Cmax by 16% and a mean decrease in olanzapine clearance by 16%. No interactions with lithium or biperiden have been observed.

Antihypertensive drugs. The drug can significantly enhance the effects of certain medications. Therefore, it should be taken with extreme caution. All this indicates that Zalasta q-tab should be used only with the permission of a doctor.

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Storage conditions

Storage conditions of Zalasta q-tab must be observed. Temperature conditions play a special role. It is desirable that it does not exceed room temperature. It should be a dry, warm place without excess moisture and direct sunlight.

It is extremely important to observe special storage conditions for the drug. It is advisable to keep the medication in its original packaging at all times. Children should not have access to this medication. They may mistakenly take it and thereby cause a strong allergic reaction of the body and overdose symptoms. In large doses, the drug can lead to death.

It is desirable that the product be kept in the first aid kit and taken out only when necessary. Correct observance of all the above conditions will result in no one being harmed and the medicine will serve the person for the specified period. Zalasta q-tab is a powerful product that can be beneficial and cause serious harm to the body.

Shelf life

The shelf life of the drug is 3 years. But without special storage conditions, these are just numbers. It is desirable that the medicine is always in the original packaging. Changes in the external qualities of the tablets, as well as the smell and taste, indicate that you should not take it. There is a risk of getting serious complications. The integrity of the packaging and blister must be constantly monitored.

The temperature regime plays a special role. It is desirable that it does not go beyond 15-25 degrees. A warm, dry place without direct sunlight is ideal for this drug. It is important that children do not have access to the medicine. Babies should never take this drug. It has a powerful effect and, if used incorrectly, can cause a number of negative reactions from many organs and systems. For a child, the use of any dose of this drug can lead to death. Zalasta q-tab has a positive effect only on adults due to its individual characteristics.

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