Zaditen

Indications Zaditen

The very fact that it belongs to antiallergic drugs that help stabilize cell membranes indicates the area of medicine in which this drug is used.

Indications for use of Zaditen are as follows:

• Prevention and treatment of allergic diseases of various origins.
• Preventive measures to prevent exacerbation of symptoms in bronchial asthma.
• Treatment of chronic and severe forms of urticaria.
• Atopic dermatitis is a chronic allergic skin disease that occurs in people genetically predisposed to atopy. It often has a recurring course.
• Allergic conjunctivitis.
• Rhinitis of allergic etiology.

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Release form

Modern pharmacology is ready to offer its buyer a fairly good range of products. The form of release, which is presented by Zaditen, its composition and single dosage are somewhat different.

Eye drops

Per 1 ml. The basic substance is ketotifen fumarate with a dosage of 0.345 mg, and auxiliary substances: glycerin (or glycerol), benzalkonium chloride, water for injection and sodium hydroxide solution.

One pack contains one bottle of the drug.

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Zaditen tablets

One unit of the drug contains 1 mg of the main active substance ketotifen, which is presented here in the form of hydrogen fumarate. In addition to it, there are also other accompanying substances.

The packaging contains a tube with 30 tablets.

Zaditen syrup

This form of release was developed specifically for small patients. 5 ml of the drug contains 1 mg of ketotifen in the same form in which it is presented in tablets.

The syrup can be found in a 100 ml bottle at the pharmacy.

Pharmacodynamics

Zaditen is an antiallergic drug. Therefore, the pharmacodynamics of Zaditen is associated with the membranes of mast cells, the processes in which tend to a stable, steady state. Zaditen reduces the amount of biologically active elements released from cells, such as leukotrienes, lymphokines, histamines and some other mediators.

The drug covers H1-histamine receptors quite well, reduces the rate of reactions such as phosphodiesterase, inhibits the reactive sensitivity of eosinophils, prevents their accumulation and deposition in the human respiratory tract caused by the activation of allergens or platelets. Zaditen stimulates an increase in the cAMP index in cells, suppresses the work of the central nervous system, does not lead to the development of spasmodic reactions in the bronchi. The effectiveness of clinical administration of the drug is manifested in six to eight weeks.

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Pharmacokinetics

The kinematic patterns that are inherent in the course of biological and chemical processes in the human body are the pharmacokinetics of Zaditen.

Absorption process. Due to relatively good metabolism, biological absorption of the drug is 50%. The maximum content of Zaditen in the blood plasma will be reached two to four hours after taking the drug.

Metabolism and elimination of the drug. The basic substance of the drug (ketotifen-N-glucuronide) has virtually zero activity. No specific features of the metabolism of the active component of the drug in children have been identified and they proceed in exactly the same way as in adults, but the rate of purification of biological tissues of the body (clearance) in children is significantly higher. Based on this, the dosage for children over three years old is the same as for adults.

Approximately 1% of Zaditen is excreted by the kidneys through urine virtually unchanged over two days, and 60-70% of this drug is glucuronide metabolites.

Food intake has no effect on the pharmacokinetics of Zaditen.

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Dosing and administration

The method of administration and dosage of the drug Zaditen largely depend on the age category of patients, as well as on the form of administration of the drug.

If the drug is prescribed in the form of drops, it is applied conjunctivally, that is, by instillation into the conjunctival sac. Patients over 65 years of age and children who are already three years old are given one drop twice a day. Adults under 65 receive two drops twice a day.

For children aged six months to three years, if medically necessary, Zaditen is prescribed in the form of syrup. The method of administration and dosage are reduced to figures prescribed at the rate of 0.25 ml (0.05 mg) per kilogram of the baby's weight. For example, if the child weighs 10 kg, then the drug should be used in a dosage of 2.5 ml. Take the syrup twice a day (morning and evening).

Children over three years of age are prescribed syrup in a dose of 5 ml (according to the measuring container) twice a day.

Zaditen tablets are prescribed to an adult patient in a dosage of 1-2 mg of the drug twice a day, with the maximum daily dosage being 4 mg. For children, as in the case of the syrup form, the dosage is calculated at 0.05 mg per kilogram of the baby's weight.

The duration of the treatment course is determined taking into account the severity of the disease and the patient's condition, but it should not exceed six weeks.

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Use Zaditen during pregnancy

There have been no clinical or laboratory monitoring or studies that would suggest the use of Zaditen during pregnancy. In this regard, the manufacturer does not recommend prescribing and using the drug in question during pregnancy and breastfeeding until the negative impact of Zaditen on the fetus or the health of the newborn is confirmed or refuted.

Contraindications

To date, no contraindications to the use of Zaditen have been identified. Unless such contraindications include individual hypersensitivity to the components of the drug. It is also worth prescribing it to children under three years of age with caution. In this case, the attending physician must weigh all the pros and cons and decide to use the drug only if the potential benefit from using the medication outweighs the risk of possible consequences.

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Side effects Zaditen

It should be remembered from the start that side effects of Zaditen may or may not occur. The frequency of such manifestations is not high and is only 1%, but it should not be thrown off the boards. However, when taking this medication, the following unpleasant phenomena may occur.

• Skin rashes may occur.
• The appearance of headaches and dizziness.
• Development of urticaria.
• Manifestation and progression of eczema.
• The patient becomes lethargic and constantly sleepy. In this case, it is worth giving up driving a car or working with tools and mechanisms.
• Decreased overall tone of the body, slow reactions.
• Irritability. This is especially true for young patients.
• The oral cavity feels a lack of moisture – dryness appears.
• Nausea, less often vomiting.
• When using the drop form of the drug Zaditen, unpleasant sensations may appear in the eyes: burning, itching in the eyelid area, may manifest as small inclusions of corneal erosion. Such pathology occurs in up to two percent of cases.
• Symptoms of dry eyes and photophobia may appear.
• In quite rare cases, side effects of Zaditen may include subconjunctival hemorrhages.
• Conjunctivitis and edema. These manifestations are observed in less than one percent of cases.
• Exacerbation of stomach diseases, constipation.
• Cystitis and dysuria.
• Thrombocytopenia.
• Increased appetite and, as a consequence, weight gain in the patient.

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Overdose

When reviewing and analyzing cases of taking the drug Zaditen, no overdose was detected. Even taking ketotifen, the basic active substance of the drug, in doses higher than 20 mg daily did not lead to the manifestation of serious negative symptoms.

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Interactions with other drugs

There have been no studies on the interaction of Zaditen with other drugs, so there is no official data. But do not forget that the drug contains benzalkonium chloride, which can penetrate into the material of soft contact lenses. Based on this, before using Zaditen drops, you must remove the lenses and only after some time (at least 15 minutes) can they be put on again. If there are several drugs that need to be introduced into the conjunctival sac, then between their use it is necessary to maintain a pause of at least five minutes.

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Storage conditions

The storage conditions for Zaditen are no different from those of many other drugs. The temperature of the room in which this medicine is stored should not exceed 25 °C. The storage area should be inaccessible to children.

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Shelf life

The expiration date of the drug is necessarily indicated on the packaging and is 24 months (or two years). If the shelf life of Zaditen has expired, the drug should not be used. After the medicine has been opened and started to be used, removing the seal from the bottle, the expiration date is sharply reduced and is only one month.

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