Zaditen

Indications Zaditen

Already the very belonging to antiallergic drugs, which contribute to the stabilization of cell membranes, indicates the field of medicine in which this drug is used.

Indications for use Zaditen are as follows:

• Prevention and treatment of allergic diseases of various genesis.
• Preventive measures to prevent exacerbation of symptoms in bronchial asthma.
• Treatment of chronic and severe forms of hives.
• Atopic dermatitis is a chronic manifestation of allergic skin diseases that occur in individuals genetically predisposed to atopy. Often has a recurrent course.
• Conjunctivitis of allergic manifestations.
• Rhinitis of allergic etiology.

[1], [2], [3], [4], [5]

Release form

Modern pharmacology is ready to offer its buyer a fairly good range of products. The form of the release, which is presented by Zaditen, its composition and single dosage is somewhat different.

Eye drops

For 1 ml. The basic substance is ketotifen hydrofumarate with a dosage of 0.345 mg, and auxiliary: glycerin (or glycerol), benzalkonium chloride, water for injection and sodium hydroxide solution.

One pack contains one bottle of the drug.

[6], [7], [8]

Tablets Zaditen

One unit of the drug contains 1 mg of the basic active substance ketotifen, which is represented here in the form of hydrogen fumarate. In addition, other related substances are also included.

Packing has a tube with 30 tablets.

Syrup Zaditen

This form of release was developed specifically for young patients. 5 ml of the drug contains 1 mg of ketotifen in the same form in which it is presented in tablets.

The syrup in the pharmacy can be found in a 100 ml vial.

Pharmacodynamics

Zaditen is an antiallergic drug. Therefore, the pharmacodynamics of Zaditen is associated with the membranes of mast cells, the processes in which they tend to a stable, stable state. Zaditen reduces the number of biologically active elements released from the cells, such as leukotrienes, lymphokines, histamines and some other mediators.

The drug covers well the H1-histamine receptors, reduces the rate of reactions such as phosphodiesterase, depresses the reactivity of eosinophils, prevents their accumulation and deposition in the airway of a person caused by the activation of allergens or platelets. Zaditen stimulates an increase in cAMP in the cells, suppresses the work of the central nervous system, does not lead to the development of spasmodic reactions in the bronchi. The effectiveness of clinical administration of the drug manifests itself in six to eight weeks.

[9], [10], [11]

Pharmacokinetics

The kinematical regularities that are inherent in the course of biological and chemical processes in the human body - this is the pharmacokinetics of Zaditen.

The suction process. Thanks to a relatively good metabolism, the biological assimilation of the drug is 50%. Maximum content Capped in blood plasma will reach two to four hours after taking the drug.

Metabolism and excretion of the drug. The basic substance of the preparation (ketotifen-N-glucuronide) has practically zero activity. Characteristic features of the metabolism of the active component of the drug in children are not revealed and they proceed exactly the same as in adults, but the rate of clearance of biological tissues of the body (clearance) in children is much higher. On this basis, the dosage for children over the age of three is the same as for adults.

Approximately 1% Seized for two days is excreted by the kidneys through the urine practically unchanged, and 60-70% of this drug is glucuronide metabolites.

The intake of food has no effect on the pharmacokinetics.

[12], [13], [14]

Dosing and administration

The method of application and dose of Zaditen drug largely depend on the age category of patients, as well as on the form of taking the drug.

If the drug is prescribed in the form of drops, it is used conjunctivally, that is, by digesting into the conjunctival sac. Patients over the age of 65 and babies who are already three years old are dripping one drop twice during the day. Adults under 65 receive two drops twice a day.

Children age from six months to three years, with medical necessity, appoint Zaditen in the form of syrup. The method of administration and dose are reduced to figures assigned at the rate of 0.25 ml (0.05 mg) per kilogram of the baby's weight. For example, if a child weighs 10 kg, then the drug should be administered in a dosage of 2.5 ml. Take the syrup twice a day (morning and evening).

Children who are older than three years are prescribed a syrup dose of 5 ml (according to the measured capacity) twice a day.

Zaditen tablets are attributed to an adult patient at a dosage of 1-2 mg of the drug twice a day, with a maximum daily dosage of 4 mg. To children, as in the case of the syrup release form, the dosage is calculated to be 0.05 mg per kilogram of the baby's body weight.

The duration of the treatment course is determined taking into account the severity of the disease and the patient's condition, but it should not exceed six weeks.

[23], [24]

Use Zaditen during pregnancy

There is no clinical and laboratory monitoring or research that would suggest the use of Zaditen during pregnancy was not performed. In connection with these prescribe and apply the drug in question during pregnancy and breastfeeding, the manufacturer does not recommend until confirmation or refutation of the negative effect. It is suspected of the fetus or health of the newborn.

Contraindications

To date, no contraindications to the use of Zaditen have been identified. Unless, that to those it is possible to carry individual increased sensitivity to the constituent components of the drug. It should also be cautiously attributed to children who are not yet three years old. In this case, the treating physician needs to weigh the pros and cons and decide on the use of the drug only if the potential benefit of using the medication exceeds the risk of possible consequences.

[15], [16], [17], [18],

Side effects Zaditen

It should be remembered from the outset that Zaditen's side effects may or may not occur. The frequency of such manifestations is not great and amounts to only 1%, but it should not be discarded from shields. Nevertheless, when taking this medication, the following unpleasant phenomena may occur.

• There may be skin rashes.
• Appearance of headache and dizziness.
• Development of hives.
• Manifestation and progression of the specimen.
• The patient becomes sluggish, it constantly tends to sleep. In this case, it is necessary to abandon the control of the car or from working with tools and mechanisms.
• Decrease in the general tone of the body, slowness in reactions.
• Irritability. This is most relevant for small patients.
• The oral cavity feels a lack of moisture - there is dryness.
• Nausea, rarely vomiting.
• With the application of the droplet medication Zaditen, in the eyes there may be unpleasant sensations: burning, itching in the eyelids, may appear small inclusions of corneal erosion. This pathology occurs up to two percent of cases.
• Perhaps the appearance of the symptoms of "dry eyes" and photophobia.
• In fairly rare cases, side effects may be subconjunctival hemorrhage.
• Conjunctivitis and puffiness. These manifestations are observed in less than one percent of cases.
• Exacerbation of stomach diseases, constipation.
• Cystitis and dysuria.
• Thrombocytopenia.
• Increased appetite, and as a result, increased weight of the patient.

[19], [20], [21], [22],

Overdose

Considering and analyzing the cases of taking Zaditen drug, an overdose was not revealed. Even the administration of ketotifen, the basic active substance of the drug, in doses above 20 mg daily did not lead to serious negative symptoms.

[25], [26], [27], [28],

Interactions with other drugs

Studies of the interaction Zaditen with other drugs have not been conducted, so there is no official data. But do not forget that the drug includes benzalkonium chloride, which is capable of seeping into the material of soft contact lenses. Therefore, before using Zaditen drops, it is necessary to remove the lenses and only after a certain time (at least 15 minutes) they can be worn again. If there are several drugs that need to be injected into the conjunctival sac, then between their application it is necessary to maintain a pause of at least five minutes.

[29], [30], [31], [32], [33],

Storage conditions

Storage conditions Zaditen do not differ from the conditions of many other preparations. The temperature of the room in which the medicinal product is stored should not exceed 25 ° C. It is necessary that the storage space is not available for children.

[34], [35], [36],

Shelf life

The shelf life of the drug is mandatory on the packaging and is 24 months (or two years). In the case when the period of storage of Zaditena has come to an end, use the drug is not worth it. After the medical device has been opened and started to be applied, having removed the seal from the bottle, the shelf life is sharply reduced and is only one month.

[37],