Yonosterol

Infusion solution for intravenous infusion of lonostearil is used to normalize the electrolyte balance when it is disturbed. Refers to the category of replenishing electrolytes.

Yonosteryl is intended for stationary use. The drug release in pharmacies is limited.

Indications Yonosterol

Yonostearil is used to normalize electrolyte equilibrium in the following situations:

• for replenishment of the liquid and electrolyte volume in patients with normal acid-base balance, or in diagnosed or impending acidosis;
• for a one-time replenishment of intravascular fluid volume (with heavy blood loss or burn injuries);
• with isotonic dehydration of various etiologies (with diarrhea, debilitating vomiting, fistulas, intestinal obstruction, etc.);
• hypotonic dehydration.

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Release form

The solution of Yonosteril is dispensed in glass transparent bottles of 250, 500 ml and 1 l, as well as in plastic vials or bags of polymer.

The primary carton pack contains 10 bottles and the instruction to the preparation.

The solution of Yonostearil is a clear, colorless liquid.

Pharmacodynamics

The medication Jonosteril is an isotonic solution of electrolyte with the content of basic cations involved in the normalization of plasma blood composition and used for regeneration of liquid and electrolyte equilibrium. Electrolyte components are necessary for the renewal and preservation of complete osmotic indices in the intercellular and intracellular space. Oxidation of acetate affects the alkalization of the equilibrium state. Since the drug Yonosteril contains metabolic anions, it can also be prescribed to patients with a tendency to develop metabolic acidosis.

Electrolytes of sodium, potassium, calcium, magnesium and chlorine are in demand for the renewal or normalization of water and electrolyte homeostasis. The organic acetate anion is transformed to bicarbonate.

Pharmacokinetics

With the infusion of a solution of lonostearil, the intercellular (interstitial) space, whose volume is approximately 2/3 of the entire extracellular volume, is filled first. Only a third of the infusion of the drug is stored inside the cells, and for this reason the solution has a short hemodynamic property.

The system of renal filtration is considered the main regulating element in maintaining the water balance in the body. Chlorides, sodium and magnesium salts are excreted mainly through the kidneys, and only a small amount leaves the bloodstream through the skin and digestive tract.

Not less than 90% of potassium salts are excreted with urinary fluid, and the remaining amount - through the digestive system.

Not all components of the infusion solution of Yonosteril are excreted evenly: it depends on the individual body's need for electrolytes, on the degree of metabolism and the efficiency of the kidneys of the patient.

Dosing and administration

Infusion fluid Yonosteril is designed for intravenous and subcutaneous infusion. The amount of the drug administered is determined according to the patient's well-being and individual indicators of metabolic processes.

• Standards for intravenous infusion of lonostearil to adults and children from 12 years of age:
  • infusion rate - 5 ml per kg of weight per hour;
  • the amount of the injected drug should not be more than 40 ml per kg per day.
• Standards for intravenous infusion of Yonosteril for children:
  • the infusion rate for infants up to 1 year is 6-8 ml per kg of body weight per hour, children under 6 years of age - 4-6 ml per kg of body weight per hour, children under 12 years of age - 2-4 ml per kg of body weight per hour.

The amount of medication administered should not be more than 40 ml per kg of body weight per day.

• Subcutaneous injection of the drug Jonestomer is carried out at a rate of 20-125 ml per hour, but no more. The daily dose can be 500-2000 ml per day. Limit is the daily dosage of 3 liters, with a maximum single infusion of 1.5 liters.
• Subcutaneous infusion of lonostearil in children younger than 12 years is undesirable.

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Use Yonosterol during pregnancy

Infusion solution of lonostearil is allowed to be used for intravenous infusion to pregnant and lactating patients. The features of subcutaneous administration of the solution during pregnancy have not been studied.

If a pregnant woman is diagnosed with eclampsia, then the use of yonosteril is allowed only with an adequate assessment of the degree of probable benefit and possible risk to the fetus.

Contraindications

Infusion solution of lonostearil is not used:

• with hypersensitivity to the composition of the drug;
• if the patient is in a state of hyperhydration;
• with hyperkalemia;
• if the patient shows fluid accumulation in tissues, signs of hypertonic dehydration, as well as severe disorders of renal and cardiovascular activity.

Subcutaneous injections of Yonosteril do not:

• with severe degree of dehydration;
• If the patient is in one of the critical states - for example, in a collapse, a shock state, and also in the presence of septic complications;
• with infectious or allergic skin lesions at the site of drug administration.

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Side effects Yonosterol

The incidence of undesirable manifestations in the use of yonosteryl is relatively small. However, sometimes development is possible:

• hypersensitive response processes;
• febrile reactions;
• inflammatory process in the zone of administration;
• irritation and formation of thrombi in the injection zone;
• swelling;
• increased heart rate.

Subcutaneous injections of lonostearil may be accompanied by small local edema.

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Overdose

If the excess amount of the drug is accidentally poured or the speed of administration of Yonosteryl improperly matched, hyperhydration or sodium overload may develop, with the appearance of puffiness and partial renal excretion of sodium, as well as with electrolyte and acid-base imbalance.

Treatment for overdose:

• stopping the administration of a solution of Jonestomer;
• stimulation of kidney function and evaluation of volume balance.

When an oliguria or anuria is found, hemodialysis can be used.

Interactions with other drugs

The liquid solution of Yonostearil contains calcium in its composition. In this regard, the drug may precipitate when using medicines in which oxalates, phosphates, carbonates or hydrogen carbonates are present.

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Storage conditions

Packages with infusion solution of lonostearil are kept away from sunlight, in rooms with a temperature index not exceeding + 25 ° C.

Children should not be allowed to store medicines.

Shelf life

The solution of Yonostearil can be stored for up to 5 years.