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Yonosteril
Last reviewed: 03.07.2025

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Infusion solution for intravenous infusion Jonosteril is used to normalize electrolyte balance when it is disturbed. Refers to the category of replenishing electrolytes.
Jonosteril is intended for inpatient use. The drug is available in pharmacies only with limited availability.
Indications Yonosteril
Jonosteril is used to normalize electrolyte balance in the following situations:
- to replenish fluid and electrolyte volume in patients with normal acid-base balance, or in cases of diagnosed or impending acidosis;
- for one-time replenishment of intravascular fluid volume (in case of profuse blood loss or burn injuries);
- in isotonic dehydration of various etiologies (diarrhea, debilitating vomiting, fistulas, intestinal obstruction, etc.);
- in case of hypotonic dehydration.
Release form
Jonosteril solution is available in transparent glass bottles of 250, 500 ml and 1 l, as well as in plastic bottles or polymer bags.
The primary cardboard packaging contains 10 vials and instructions for the drug.
Jonosteril solution is a transparent, colorless liquid.
Pharmacodynamics
The drug Jonosteril is an isotonic electrolyte solution containing basic cations that participate in the normalization of the plasma composition of the blood and are used to regenerate the fluid and electrolyte balance. Electrolyte components are necessary for the restoration and preservation of full osmotic parameters in the intercellular and intracellular space. Acetate oxidation affects the alkalization of the equilibrium state. Since the drug Jonosteril contains metabolic anions, it can also be prescribed to patients with a tendency to metabolic acidosis.
Electrolytes sodium, potassium, calcium, magnesium and chlorine are required to restore or normalize water and electrolyte homeostasis. Organic acetate anion is transformed to bicarbonate.
Pharmacokinetics
When infusing the Jonosteril solution, the intercellular (interstitial) space is filled first, the volume of which is approximately 2/3 of the total extracellular volume. Only a third of the infused amount of the drug is retained inside the cells, and for this reason the solution has a short hemodynamic property.
The renal filtration system is considered the main regulatory link in maintaining water balance in the body. Chlorides, sodium and magnesium salts are excreted mainly through the kidneys, and only a small amount leaves the bloodstream through the skin and digestive tract.
At least 90% of potassium salts are excreted with urine, and the remaining amount is excreted through the digestive system.
Not all components of the Jonosteril infusion solution are excreted evenly: this depends on the individual need of the body for electrolytes, the degree of metabolism and the performance of the patient's kidneys.
Dosing and administration
Infusion fluid Ionosteril is intended for intravenous and subcutaneous infusions. The amount of the drug administered is determined according to the patient's well-being and individual metabolic process indicators.
- Standards for intravenous infusion of Jonosteril for adult patients and children over 12 years of age:
- infusion rate – 5 ml per kg of weight per hour;
- the amount of the drug administered should not exceed 40 ml per kg per day.
- Standards for intravenous infusion of Jonosteril for children:
- The infusion rate for infants under 1 year old is 6-8 ml per kg of weight per hour, for children under 6 years old – 4-6 ml per kg of weight per hour, for children under 12 years old – 2-4 ml per kg of weight per hour.
The amount of medication administered should not exceed 40 ml per kg of weight per day.
- Subcutaneous administration of the drug Jonosteril is carried out at a rate of 20-125 ml per hour, but no more. The daily dose can be equal to 500-2000 ml per day. The maximum daily dosage is considered to be 3 liters, with a maximum single infusion of 1.5 liters.
- Subcutaneous infusion of Jonosteril in children under 12 years of age is not recommended.
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Use Yonosteril during pregnancy
The infusion solution Jonosteril is permitted for intravenous infusion in pregnant and lactating patients. The features of subcutaneous administration of the solution during pregnancy have not been studied.
If a pregnant woman is diagnosed with eclampsia, the use of Jonosteril is permitted only with an adequate assessment of the degree of probable benefit and possible risk to the fetus.
Contraindications
Jonosteril infusion solution is not used:
- in case of hypersensitivity to the composition of the drug;
- if the patient is in a state of hyperhydration;
- in hyperkalemia;
- if the patient has fluid accumulation in the tissues, signs of hypertensive dehydration, as well as severe renal and cardiovascular disorders.
Subcutaneous injections of Jonosteril are not performed:
- in case of severe dehydration;
- if the patient is in one of the critical conditions - for example, in collapse, shock, or in the presence of septic complications;
- in case of infectious or allergic lesions of the skin at the site of drug administration.
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Side effects Yonosteril
The frequency of adverse events when using Jonosteril is relatively low. However, sometimes the following may develop:
- hypersensitive response processes;
- febrile reactions;
- inflammatory process in the injection area;
- irritation and formation of blood clots at the injection site;
- swelling;
- increased heart rate.
Subcutaneous injections of Jonosteril may be accompanied by slight local swelling.
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Overdose
If an excessive amount of the drug is accidentally injected or the rate of administration of Jonosteril is incorrectly selected, hyperhydration or sodium overload may develop, with the appearance of edema and partial impairment of renal sodium excretion, as well as electrolyte and acid-base imbalance.
Treatment measures in case of overdose:
- discontinuation of administration of Jonosteril solution;
- stimulation of kidney function and assessment of volume balance.
If oliguria or anuria is detected, hemodialysis may be used.
Interactions with other drugs
The liquid solution Jonosteril contains calcium. Therefore, the drug may precipitate when used simultaneously with medications containing oxalates, phosphates, carbonates or bicarbonates.
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Storage conditions
Packages with Jonosteril infusion solution are stored away from sunlight, in rooms with a temperature not exceeding +25°C.
Children should not be allowed near places where medicines are stored.
Shelf life
Jonosteril solution can be stored for up to 5 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Yonosteril" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.