Yodoxide

Active substance Yodoxidum is povidone-iodine - an antiseptic and disinfectant with a wide spectrum of action.

The drug is an antiseptic and is used for local treatment in gynecology. 

Indications Yodoxide

Yodoksid is prescribed for acute and chronic vaginal infections (bacterial vaginosis, fungal infections, infections that have developed against antibiotics and steroid drugs).

The drug can be used as a preventive agent during the diagnosis or before gynecological operations.

[1], [2], [3]

Release form

Iodoxide is available in the form of vaginal suppositories, which have the form of a torpedo, color - brown or dark brown. 

Suppositories Iodoxide

Suppositories Iodoxide are used to treat infectious and inflammatory diseases of the vagina in acute and chronic form.

Iodine suppositories can be prescribed to reduce the risk of complications before setting or removing intrauterine contraceptives, abortion, x-ray examination of the uterus, electrocoagulation of cervical erosion (cauterization), etc.

[4], [5], [6], [7]

Vaginal Suppository Yodoxide

Suppositories Yodoxide, like other drugs in this form, are the most convenient way to "deliver" the active substance directly to the affected area.

This form of release has several advantages, in comparison with creams or vaginal tablets:

• thanks to a soft base, the suppository smoothly covers the entire mucous membrane of the vagina, and the active substance is evenly distributed over the surface
• iodine suppository softens the mucous membrane and flushes the pathogenic flora from the vagina
• candles do not damage the mucous membrane upon administration (as opposed to tablets)

Pharmacodynamics

Iodide is a complex of iodine and polyvinylpromidone (PVP), which releases iodine for a certain time after application to the skin or mucous membranes.

Iodine has a powerful bactericidal effect, has a broad antimicrobial effect, destroys viruses and protozoan microorganisms.

Upon contact with the skin or mucous membranes, PVP releases a significant amount of iodine, which reacts with proteins of the pathogenic flora and destroys them.

Most of the pathogenic microorganisms die in the first minutes after iodine hits the skin or mucous, while iodine loses its rich brown color.

With prolonged use of the drug in pathogenic microorganisms, resistance to the active substance does not develop.

[8], [9], [10], [11], [12], [13], [14], [15], [16], [17]

Pharmacokinetics

Iodine oxide may cause an increase in the amount of iodine in the blood in prolonged use. Normally, the iodine level returns after 1-2 weeks after discontinuation of the drug.

When the thyroid gland is working normally, the drug does not cause an increase in iodine reserves and does not affect the hormonal background.

After vaginal administration, the elimination half-life is approximately 48 hours. It is excreted from the body mainly by the kidneys.

[18], [19], [20], [21]

Dosing and administration

Iodine oxide is used vaginally.

It is recommended to inject the suppository into the vagina once a day for a week.

In severe infections, the drug is used for 2 weeks.

With persistent infections, administration of suppositories is prescribed 2 times a day.

Before the introduction of the suppository to pull out of the shell, lightly moisten and insert deeply into the vagina in the supine position. During treatment it is recommended to use disposable sanitary napkins.

Suppositories should be administered overnight. The drug is used regardless of the menstrual cycle. 

[29], [30], [31], [32]

Use Yodoxide during pregnancy

Iodoxide does not affect embryonic development. Iodine suppositories are contraindicated after the second month of pregnancy and during breastfeeding, as iodine is able to penetrate the placenta and into breast milk.

Contraindications

Iodoxide is contraindicated in case of strong susceptibility of the body to iodine or other components of the drug (or suspected of increased sensitivity).

Also, iodine suppositories are not prescribed for thyroid dysfunction, before and after treatment with radioactive iodine, with Dühring's disease (skin damage), kidney failure. 

[22],

Side effects Yodoxide

Iodine oxide is usually well tolerated by patients, in some cases local reactions are observed (hypersensitivity, itching, burning, swelling, rash, redness, etc.).

Iodine suppositories can cause an increase in the level of iodine in the blood, kidney failure, disruption of the kidneys.

In some cases, acute reactions to the drug, including anaphylactic shock, lowering blood pressure, difficulty breathing. 

[23], [24], [25], [26], [27], [28]

Overdose

Iodine oxide in case of exceeding the dose may cause a taste of metal in the mouth, severe salivation, skin reactions (rash, itching), digestive disorders, renal dysfunction, renal tubular dysfunction, urinary incontinence, larynx, lungs, eyes. 

[33], [34], [35],

Interactions with other drugs

With simultaneous use of Yodoxide and antiseptic agents, a mutual decrease in therapeutic effectiveness is possible.

Iodine suppositories are not used with mercury-containing drugs, do not prescribe a long course for patients receiving lithium preparations.

Due to the oxidative properties of iodine, the results of some diagnostic tests may be incorrect. 

[36], [37], [38]

Storage conditions

Iodioxide must be stored in a place where sunlight does not penetrate, at a temperature of no more than 25 ° C. 

[39], [40]

Special instructions

Instructions for use

Iodoxide is used in gynecology for the treatment of bacterial infections, and as a preventive measure before surgery in the vagina or in diagnostic procedures.

The drug is available in the form of vaginal suppositories, which are recommended to be slightly moistened before introduction into the vagina.

Usually prescribed 1-2 candles per day (depending on the causative agent of the infection). 

Iodoxide for thrush

Yodoksid is used to treat candidiasis (thrush). Iodine suppositories have a broad antimicrobial effect and help get rid of the disease within a week.

To treat thrush, the suppository is recommended to be injected deep into the vagina in a lying position in the morning and evening. 

Price

The cost of vaginal suppositories Iodoxide in the region of 100 -130 UAH.

Analogues

The following preparations have the analogous action of Yodoxide:

Vokadin, Betadin.

[41], [42], [43], [44],

Yodoxide or Betadine

Iodoxide and Betadine include the same active ingredient. Both drugs are antiseptic, have a wide range of antiviral and antimicrobial effects.

Reviews

Reviews about the drug Yodoxid mostly positive.

Some patients note that during treatment, burning occurs at the site of treatment (sometimes quite strong), in addition, the suppository can be stained with laundry, so it is better to additionally use sanitary napkins.

During treatment, brownish discoloration may appear throughout the course of treatment.

Iodoxide is used for vaginal infections. The drug effectively destroys fungi, viruses and bacteria.

Iodine suppositories contain iodine, so during the treatment there may be a slight burning and brownish discharge from the vagina. 

Shelf life

The medication is suitable for use 36 months from the date of manufacture. 

[45], [46], [47], [48], [49]