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Health

Yarina plus

, medical expert
Last reviewed: 23.04.2024
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We offer you the instruction on the use of medication Jarina plus - a representative of monophasic oral contraceptives.

The manufacturer of the drug is the German company Bayer Pharma AG.

Indications Yarina plus

  • Prevention of conception in women who have signs of hormone-dependent swelling of tissues.
  • Prevention of unwanted pregnancy and therapy of mild acne.
  • Prevention of unwanted conception in women with a deficiency of folic acid derivatives and B vitamins.

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Release form

The drug Yarina plus is available in tablet form in the form of two kinds of tablets:

  • active complex tablets: rounded, convex on both sides, having on the surface a thin film of orange color. On one of the surfaces the designation "Y +" is made, enclosed in a hexagon;
  • additional multivitamin preparations: rounded, convex on both sides, with a thin film coating of a light orange color. On one of the surfaces is made the designation "M +", enclosed in a hexagon.

The composition of the active complex tablet is:

  • drospirenone (a derivative of spironolactone) in an amount of 3 mg;
  • ethinyl estradiol (hormonal estrogenic agent) 0.03 mg;
  • calcium levomefolate (an analogue of folates) 0.451 mg;
  • additional components: lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, giprolose;
  • components of the outer film: lacquer coating, or hypromellose, macrogol, talc, dyes (red and yellow iron oxide), titanium dioxide.

Composition of an additional vitamin preparation is presented:

  • levomefolatom sodium, lactose, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, giprolose;
  • components of the outer film: lacquer coating, macrogol, talc, dyes (red and yellow iron oxide), titanium dioxide.

In the cell packaging there are 21 active tablets and 7 additional ones, sealed in aluminum foil. A set of stickers is included in the kit for the convenience of keeping a calendar of tablets.

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Pharmacodynamics

Contraceptive Yarin plus is a low-concentration single-phase complex hormonal preparation for internal use. It includes active ingredients and additional tablets containing calcium levomolephate.

Contraceptive ability of Yarina plus is explained by oppression of the ovulation process and increased density of cervical mucus. In patients who use complex contraceptives, the monthly cycle stabilizes, menstruation becomes easier, the risk of anemia is eliminated. Experts argue that the use of such contraceptives can serve as a prevention of malignant disease of the endometrium and appendages.

One of the main components of the drug - drospirenone - shows an antimineralocorticoid effect and prevents hormone-dependent swelling of the tissues. This serves to prevent weight gain and fluid retention in the body. Another ability of the drpyrenone is to eliminate acne and relieve the fatiness of the hair and skin. This is explained by the similar action of this substance with the natural property of progesterone.

If the drug is used and taken correctly, the incidence of pregnancy in women may be less than 1%. If the tablets are taken chaotically or missed, the probability of pregnancy against the background of the use of Yarin plus significantly increases.

Another of their components - levomefolat - can be imagined as a bioactive form of folate. This form allows the substance to be metabolized more fully than folic acid. Usually, levomefolat is prescribed in order to provide the body of a pregnant or nursing woman with the right amount of folate. The presence of the same substance in the contraceptive drug is explained by the fact that levomefolat can reduce the risk of neural tube pathology in the embryo, if the patient wants to become pregnant immediately after the termination of the contraceptive course.

Pharmacokinetics

When ingested, the active ingredient of the drug is soon absorbed into the blood. After a single internal use, the limiting level of drospirenone and ethinylestradiol is observed after 60-120 minutes and reaches 37 ng / ml and 54-100 pg / ml, respectively. The biological availability of the substance drospirenone - 76-85%, ethinyl estradiol - 20-65%. Simultaneous eating does not affect the bioavailability of the drug, only in some cases it can be reduced to 25%.

The active substance comes into contact with the serum protein. Only up to 5% of the total level appears in the plasma in the form of a free hormonal substance, while about 95% enters the protein in a non-specific way. An increase in the level of sex hormones does not affect the connection of drospirenone with plasma proteins.

After internal use, drospirenone leaves the body through the digestive system and kidneys. The level of sex hormones does not affect the pharmacokinetic properties of drospirenone.

If the drug is taken according to the schedule, then the daily level of drospirenone in the serum will increase by two or even three times. A stable level is observed in the II phase of the treatment cycle.

Dosing and administration

How and according to what scheme should I use Yarina plus?

The drug is administered orally following the instructions attached to the contraceptive. The regimen assumes the use of the drug at the same time, swallowing whole, washed down with clean water. Tablets are used in an amount of one piece per day, without missing a dose, for 28 days. After the exhaustion of the package, the following is started.

Begin receiving a contraceptive from the first day of menstruation.

With the phenomena of dyspepsia (attacks of vomiting and diarrhea), the absorption of the drug can be disrupted, therefore in this situation it is necessary to take additional contraceptive measures.

The drug is used in women of childbearing age category, which does not include children and patients with the onset of menopause.

In disorders of hepatic and renal function, the drug is not used.

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Use Yarina plus during pregnancy

Yarina plus is not used in pregnancy. In cases where pregnancy is detected during the course of taking a contraceptive, the use of the drug should be stopped immediately.

There is practically no information on how and to what extent the drug affects the fetus and course of pregnancy. Nevertheless, in the course of observations, specialists did not find any developmental defects in children born to women who used Yarin plus before pregnancy or in the first weeks of pregnancy. However, it should be borne in mind that no special studies have been conducted on this issue.

Yarina plus not taken with breastfeeding. The use of the drug can reduce the amount of milk in a nursing woman, and also affect its composition. In addition, sex hormones in small amounts can get into the milk, although the degree of their effect on the baby is not determined.

Contraindications

  • Propensity to allergic reactions to any component of the contraceptive Yarina plus.
  • Propensity to formation of thrombi, thromboembolism, vascular wall integrity disorders, cerebrovascular disorders.
  • Ischemia, stenocardia and other pre-thrombotic conditions.
  • Migraine conditions with neurological symptoms.
  • Vascular complications of diabetes mellitus.
  • Hepatitis, signs of liver failure.
  • Inadequate kidney function.
  • Various neoplasms in the liver.
  • Hormonal-dependent tumor processes, or tumors of unknown origin.
  • Bleeding from the genitals of unexplained etiology.
  • The period of pregnancy and breastfeeding.
  • Intolerance of some components of the drug, for example, lactose.

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Side effects Yarina plus

Side effects Yarina plus can occur with varying frequency and intensity, sometimes not manifesting at all. We will tell you about the most frequent of them.

  • Allergic reactions to the drug.
  • Weight fluctuations in one direction or another, often due to swelling.
  • Oppressed state, violation of sexual activity, mood change.
  • Migraine headaches.
  • Aversion of contact lenses.
  • Development of deafness.
  • Disorders of vascular circulation, fluctuations in blood pressure, the likelihood of blood clots.
  • Diseases of the respiratory system, asthmatic conditions.
  • Dyspeptic phenomena.
  • Skin lesions, eczematous eruptions, hives.
  • Soreness of the mammary glands, thrush, disorder of the monthly cycle, inflammatory processes in the vagina, the appearance of discharge from the chest, swelling of the glands.

Among the more complex side effects are the following:

  • thromboembolism, both in veins and in arteries;
  • disorders of the cerebral vascular system;
  • hypertension;
  • increased levels of potassium and triglycerides in the blood;
  • impaired glucose susceptibility and insulin resistance;
  • neoplasms in the liver, violations of its function;
  • the appearance of hyperpigmentation of the skin;
  • angioedema;
  • calculous cholecystitis, systemic lupus erythematosus, herpetic eruptions, deafness (otosclerosis), ulcerative lesions of the intestinal mucosa, oncology of the cervix.

Overdose

The situation with an overdose of contraceptive Yarin plus was not observed.

Presumably, an overdose can be manifested in the form of dyspeptic disorders, bleeding from the genital tract, metrorrhagia.

A special drug that neutralizes the effect of a contraceptive has not been developed.

As a rule, Yarina plus well tolerated by patients.

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Interactions with other drugs

The combined use of drugs that boost the induction of microsomal hepatic enzymes leads to an increase in the clearance of certain hormones. Among such drugs are allocated hypnotic drugs, carbamazepine, griseofulvin, preparations of St. John's Wort, rifampicin. With the combined use of these drugs, additional barrier methods of contraception must be applied.

Many antibacterial drugs (mainly penicillin and tetracycline) have the ability to lower the hepatic-intestinal recurrent circulation of estrogens, which leads to a decrease in the level of ethinyl estradiol. In connection with this, it is recommended that additional external methods of contraception be used for treatment with antibiotics and for a week after the end of the course of treatment.

Antiepileptic drugs, methotrexate, triamterene, cholestyramine can lower the level of folate in the blood and depress the action of one of the active substances Yarin plus - levomefolata.

Yarina plus can influence the metabolism of other drugs, such as antiepileptic drugs, pyrethmamine, etc.

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Storage conditions

Yarina plus can be stored at a moderate temperature, not more than 25 ° C, always in places where children can not reach.

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Shelf life

The period of validity of the contraceptive Yarin Plus - up to 3 years.

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Attention!

To simplify the perception of information, this instruction for use of the drug "Yarina plus" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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