You need to inject the medicine into the vein or artery, with the condition that the doctor performing the procedure has experience in the field of angiology, and he is familiar with modern ways of regularly monitoring the values of the SSS and has the equipment required for this purpose. Do not administer the solution by the bolus method intravenously.
In the treatment of / in the method of pathologies of the third degree.
There is the following scheme of intravenous treatment: dissolve the contents of 2 ampoules (equal to 40 micrograms of drug) in a solution of sodium chloride (0.9%, take 50-250 ml), and then inject the obtained substance in a period of 2 hours. This dosage is applied 2 times a day.
Alternative route: once-daily infusion for 3 hours. Enter 3 ampoules (amount of 60 μg alprostadil), which are dissolved using the same amount of the above solvent.
People with disorders in the work of the kidneys (insufficiency with KK> 1.5 mg / dL) should start IV therapy with the introduction of the 1st ampoule twice a day (twice 20 μg Wap 20 ). Each of the procedures is 2 hours. Taking into account the general clinical picture, it is allowed to increase the dosage to the above standard dose in the period of 2-3 days.
People with kidney failure, and also those who are included in the risk of heart function disorder, need to limit the daily infusion volume to 50-100 ml, and the introduction must necessarily be performed with the help of an infusion device.
Treatment of pathologies of 3rd and 4th degree by the introduction of drugs into the arteries.
Below is indicated the following scheme of the intra-arterial treatment course: dissolve within a solution of sodium chloride (0.9%) 1-ounce ampoule (20 μg of substance). In this case, the volume of the finished solution will be half of the drug ampoule (in 25 ml of this solution - 10 μg of the drug). Infusion is carried out with the help of a special device in the period of 1-2 hours. If the tolerability of the drug remains satisfactory, it is permitted to increase the dose to the 1st ampoule (or 20 μg of the active ingredient), especially if necrosis is present on the body. Often a day requires 1 infusion.
When the infusion is performed by means of an inserted catheter, taking into account the severity of the disease and the tolerability of the drug, a dosage of 0.1-0.6 ng / kg / minute (about a quarter / half of the drug ampoule) is prescribed. In this case, the duration of the infusion using the device is 12 hours.
At the end of 3 weeks of therapy, it is necessary to determine the feasibility of subsequent use of drugs. If there is no result, it is necessary to cancel the drug. The therapeutic course can last no more than 1 month.