Warfarex has an interaction with vitamin K. When this element is contained in food products in large quantities, the effectiveness of the drug may be weakened. Antibiotics with a large range of activity inhibit the binding of the vitamin to the intestinal microflora, but the increase in anticoagulant activity in the case of combination with antibiotics occurs rarely, because as with food, the vitamin K enters the body in the required amount.
The delayed effect of the drug on the blood circulation process may increase due to a combination with such substances as urokinase and streptokinase, and in addition heparin with quinidine and methyldopa, as well as amiodarone with diazoxide. It also includes clofibrate and erythromycin, and along with this cefmandol and ethacrynic acid with cefoperazone and chloramphenicol. In addition, such properties are metronidazole and ketoconazole with itraconazole and sulfonamides, as well as nalidixic acid, paracetamol (long-term use in large doses), and fluconazole. In addition, miconazole and aspirin, allopurinol and NSAIDs with propoxyphene and chloral hydrate, as well as sulfinpyrazone and anesthetics, tamoxifen with methylphenidate and danazol. Also included in this list are valproates, and MAO, cimetidine, quinine, thyroid hormone drugs, anabolic and androgenic drugs, glucagon with disulfiram and oral hypoglycemic drugs, and in addition vitamins such as E and A, PASK and the flu vaccine.
Individual drugs that slow platelet aggregation (such as aspirin, other NSAIDs, and in addition ticarcillin with piperacillin and dipyridamole), combined with Warfarex increase the likelihood of bleeding, although the testimony may show a normal prothrombin level.
The anticoagulant effect of the drug may have a weakening effect on nafcillin, griseofulvin with rifampicin, and in addition to antacid and diuretic drugs, carbamazepine with etchlorvinol and barbiturates, as well as primidone with estrogens, aminogluthemide with glutetimide and ascorbic acid (in high doses).
Alcoholic drinks and individual drugs (cyclophosphamide with cholestyramine and disopyramide, as well as phenytoin with glucocorticoids, corticotropin and oral contraception) are able to potentiate and weaken the properties of Warfarex.