Visine

Vizin contains the active component tetryzoline, which is an α-adrenergic stimulant. Its effect provides a vasoconstrictor effect, which helps to reduce swelling in the conjunctiva. The α-adrenergic stimulating effect of tetryzoline leads to dilation of the eye pupil and a decrease in the volume of intraocular fluid produced.

After the instillation procedure, the therapeutic effect develops after a few minutes. The duration of the effect is within 4-8 hours. [ 1 ]

Indications Visine

It is used in cases of swelling, hyperemia and lacrimation that occur due to the influence of physical or chemical agents (light, smoke, chlorinated liquid, dust, cosmetics and contact lenses) on the conjunctiva.

It is also prescribed to people with conjunctivitis of allergic origin.

Release form

The drug is released in the form of eye drops, in bottles with a capacity of 15 ml. The content of tetryzoline in 1 bottle is 0.05%.

Pharmacodynamics

Tetryzoline is a sympathomimetic, which belongs to the subgroup of imidazoline decongestants. The substance has a direct stimulation of the α-adrenoreceptors of the sympathetic nervous system; however, the effect on the β-adrenoreceptors either does not develop at all or is very weak.

After local application to the conjunctival mucosa, the drug causes a temporary vasoconstrictor effect on relatively small blood vessels, reducing vasodilation and conjunctival edema.

Pharmacokinetics

Testing involving 10 volunteers revealed that when the drug is used therapeutically in the eye, tetryzoline is found in urine and blood serum.

The serum half-life of the element is approximately 6 hours.

Total absorption in volunteers was variable, with serum Cmax values ranging from 0.068–0.380 ng/mL.

After 24 hours, tetryzoline was detected in the urine of all study participants.

Dosing and administration

It is necessary to turn the bottle with drops upside down, and then drip 1-2 drops into the conjunctival sac. During the period of 24 hours, this procedure can be repeated 2-3 times. Before performing instillation, contact lenses must be removed.

It is prohibited to use the medicine for more than 4 days in a row.

• Application for children

The medication is not prescribed in pediatrics to persons under 2 years of age.

Use Visine during pregnancy

There is a possibility of negative symptoms when using Vizin in pregnant women. Because of this, it is prescribed only when the probability of benefit from using the drops is higher than the possible risks.

Contraindications

Among the contraindications:

• closed-angle glaucoma;
• severe intolerance to the medication;
• dystrophy affecting the cornea.
• Use with great caution in individuals with coronary heart disease, high blood pressure, pheochromocytoma and thyrotoxicosis, as well as in diabetics.

Side effects Visine

The main side effects are burning, pain or redness in the eye area, irritation affecting the conjunctiva, blurred vision, signs of allergy and dilation of the pupil.

Overdose

Accidental oral ingestion of Visine may cause tachycardia, nausea, convulsions, increased blood pressure, arrhythmia, cessation of blood flow, dilation of the pupils, pulmonary edema, fever, respiratory distress, and coma.

Gastric lavage, oxygen inhalation and activated carbon are performed. In addition, phentolamine is administered intravenously at a low rate or anticonvulsants are used to stop hypertension.

Storage conditions

Vizin must be stored at a temperature that does not exceed +30°C.

Shelf life

Vizin can be used within a 3-year period from the date of production of the medicinal substance. The shelf life of an opened bottle is 1 month.

Analogues

Analogues of the drug are Visoptic and Vial with Oktilia.