Vermox

Vermox has anthelmintic activity.

Indications Vermox

It is used for the following disorders:

• anguillulosis;
• trichinosis or hookworm disease;
• ascariasis or enterobiasis;
• teniasis or trichuriasis;
• echinococcosis or multilocular echinococcosis;
• capillariasis;
• helminthiases of a mixed nature.

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Release form

The therapeutic agent is released in the form of a 2% suspension, as well as 0.1 g tablets.

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Pharmacodynamics

An anthelmintic substance with a wide range of therapeutic activity. It demonstrates an effective effect in ascariasis with enterobiasis, as well as trichuriasis. It mainly affects energetic parasitic processes. It leads to a disorder of glucose consumption and ATP binding processes, and at the same time depletes glycogen reserves. It selectively slows down the binding of β-tubulin of helminth muscle cells, which causes their paralysis and a disorder of the transport systems.

It has a detrimental effect on hookworm eggs and roundworms. Large doses of the drug are used for echinococcosis or trichinosis (extraintestinal helminths). The drug is well tolerated.

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Pharmacokinetics

The substance is practically not absorbed inside the intestine. Synthesis with blood protein is 90%.

Half-life is within 2.5-5 hours. The drug accumulates inside the fatty tissue with the liver, as well as inside the helminth larvae. Metabolic processes occur inside the liver. Approximately 5-10% of the drug is absorbed and then excreted through the kidneys. More than 90% of the drug is excreted with feces.

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Dosing and administration

The medicine must be taken orally, after eating.

In case of diagnosed enterobiasis, an adult should take 0.1 g of the drug once. In parallel, it is necessary to treat everyone living in the house. If there is a high risk of re-invasion, it is necessary to take a similar portion again after 14 days.

For teniasis, ascariasis, trichuriasis, ancylostomiasis, and also anguillulosis or helminthiasis of a mixed nature, take 0.1 g of the medicine twice a day (over a 3-day period).

For trichinosis, take 0.2-0.4 g of the preparation 3 times a day for 3 days in a row. Starting from the 4th day, increase the dose to 0.4-0.5 g 3 times a day. This dosage is taken until the 10th day.

It is necessary to take into account that within 24 hours after taking Vermox it is forbidden to eat fatty foods, drink alcoholic beverages and use laxatives. After completing the therapy, it is necessary to submit feces and smears for analysis for a 7-day period to check for the presence of helminths or their eggs. During long-term therapy, it is necessary to monitor the functioning of the kidneys and liver, as well as take a blood test.

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Use Vermox during pregnancy

The use of the drug in pregnant or lactating women is prohibited.

Contraindications

Main contraindications:

• liver failure;
• ulcerative colitis;
• the presence of intolerance to the medication;
• regional enteritis.

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Side effects Vermox

The introduction of the drug causes dizziness, abdominal pain and nausea.

Long-term use in large doses leads to the appearance of the following side effects:

• bowel movement disorder and vomiting;
• alopecia;
• headaches;
• increased creatinine levels;
• angioedema or rash;
• increased activity of liver enzymes;
• cylindruria or hematuria;
• anemia, leukopenia, and eosinophilia.

Overdose

In case of poisoning, vomiting, diarrhea, abdominal pain and nausea occur.

Long-term therapy with large doses leads to temporary liver dysfunction, hepatitis or neutropenia.

To eliminate the disorders, it is necessary to perform gastric lavage, use sorbents and perform symptomatic procedures, if necessary.

Interactions with other drugs

Combined use with cimetidine increases blood levels of mebendazole; carbamazepine, on the contrary, decreases them.

Mebendazole reduces the need for insulin in diabetics.

It is necessary to avoid combining the drug with lipophilic medications.

Storage conditions

Vermox must be maintained at temperatures of no more than 30°C.

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Shelf life

Vermox can be used for a period of 5 years from the date of release of the pharmaceutical product.

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Application for children

Vermox should not be given to infants under 2 years of age.

Most often, children are infected with enterobiasis, and in addition to this, ascariasis or giardiasis. The peaks of these diseases are often noted in 2-3-, 4-7- and 10-14-year-old children (due to enzyme deficiency, acid-base imbalances in the gastrointestinal tract, as well as its motility and healthy microflora). The time after a child has suffered an intestinal infection, and in addition after treatment with antibiotics, is considered more vulnerable to invasions.

In the case of treating ascariasis, the drug efficiency is 100%. The drug is prescribed to a child in the following doses: 2-10 year olds take 0.05 g per day, dividing the dosage into 3 doses; over 10 years old – 100 mg per day in 3 doses. Therapy lasts 3 days.

During enterobiasis (pinworm infestation), therapy lasts 1 day: a 2-5-year-old child should take a quarter of a tablet once; 5-10-year-olds – 0.5 tablet; children over 10 years old – 1 tablet. It is necessary to take the medicine again in the same portion after 14 days. In addition, the linen of all residents of the house should be washed at a high temperature (90 ^o C).

It is important to remember that the medication increases the functional activity of helminths, which sometimes causes vomiting, antiperistalsis, and the release of roundworms into the respiratory tract. In this regard, in case of intensive forms of invasion, it should be used with caution in children.

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Analogues

Analogues of the drug are Mebendazole, Vormin, Telmox 100 with Mebex, as well as Vermakar and Vero-Mebendazole.

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Reviews

Vermox copes well with the treatment of enterobiasis and ascariasis in both adults and children. Parasitologists confirm this fact in their comments. With such invasions, 100% deworming is noted. In the case of scabies, it is 91%, with teniasis - 80%, anguillulosis - 67%. Doctors believe that this drug is more effective than Pirantel in the treatment of enterobiasis, but at the same time it is much more toxic. Because of this, it is prohibited to use it as a preventive (especially for children).

Parental reviews regarding the use of drugs in children are often positive. It is noted that with therapy, improvement occurs quickly: elimination of abdominal pain, complete disappearance of allergy symptoms and stabilization of gastrointestinal function.

Negative comments usually highlight the presence of negative symptoms, although they develop rarely: pain in the abdominal area and stool disturbance. It should also be remembered that children are prescribed medication by a doctor after examination. In addition, therapy requires the use of enterosorbents and timely bowel movements.