Veloz

Veloz is a drug that slows down the activity of the proton pump.

Indications Veloza

It is used to eliminate pathologies in the gastrointestinal tract that develop under the influence of gastric juice: intestinal or gastric (peptic) ulcers, hyperacid gastritis, gastrinoma, as well as functional dyspepsia.

It is also used in the treatment of GERD and to destroy the Helicobacter pylori microbe (in combination therapy).

Release form

The release is made in tablets, in the amount of 10 pieces inside a strip. The box contains 2 or 3 such strips.

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Pharmacodynamics

The component rabeprazole belongs to the category of drugs that slow down the function of the proton pump, it has an antisecretory effect and is an antiulcer substance.

Rabeprazole inhibits the action of the enzyme H ⁺ /K ⁺ -ATPase, slowing the rate of secretion of gastric juice. The uncharged form of the drug passes through the walls of the parietal glandulocytes, penetrating into the secretory canals, where the processes of concentration and protonation of rabeprazole occur. Also, an intracellular restructuring of the active substance occurs inside them, as a result of which a cyclic sulfenamide is formed.

After this, a covalent SS compound is formed with the SH category of the H ⁺ /K ⁺ pump, after which it slows down. The formed covalent compound does not change the severity of the drug effect, taking into account the level of rabeprazole.

Irreversible blocking lasts up to 40 hours. After 1 hour, acid-suppressive effect is observed. Stable suppression of secretory processes occurs after 72 hours. This function is restored 48-72 hours after discontinuation of rabeprazole.

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Pharmacokinetics

The drug is absorbed through the intestines. Peak values are noted after 3-4 hours after oral administration. The substance indicators in the blood are determined depending on the portion size. Rabeprazole is 97% synthesized with albumin.

Bioavailability values are 52%. These values do not increase with increasing frequency of administration.

Metabolism occurs with the participation of the hemoprotein P450 system. Half-life is 1.5 hours.

The pharmacological effect lasts for a maximum of 48 hours. Elimination occurs via the hemoprotein system.

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Dosing and administration

The medicine is taken orally, without chewing the tablet or breaking its shell - it must be swallowed whole. The use of the medicine is not tied to the time of day or to food intake.

Elimination of GERD and peptic ulcers - use 20 mg of the drug twice a day. Duration of therapy:

• in case of gastric ulcer – about 2-8 weeks;
• for duodenal ulcers – approximately 0.5-1 month;
• for GERD – approximately 1-2 months.

The maintenance dose for GERD is a single dose of 10-20 mg for up to 1 year.

Elimination of functional dyspepsia, as well as hyperacid gastritis - a single dose of 40 mg or twice a day of 20 mg for 2-3 weeks.

Therapy for gastrinoma is a single daily dose of 60 mg of the drug. If necessary, the portion size can be increased until the desired treatment result is achieved.

Destruction of the Helicobacter pylori bacteria - in combination therapy, a two-time dose of 20 mg of the drug is prescribed together with an antimicrobial drug or a bismuth drug. The therapy lasts a maximum of 1 week.

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Use Veloza during pregnancy

Rabeprazole should not be administered to nursing mothers or pregnant women because it crosses the placenta and is partially excreted in breast milk.

Contraindications

Veloz should not be prescribed to children under 12 years of age, and should not be taken if there is hypersensitivity to rabeprazole or other components of the medication. The combination of the drug with atazanavir is also contraindicated.

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Side effects Veloza

The medication is well tolerated. Most often, its side effects manifest themselves in the form of bowel disorders, dyspepsia, intestinal flatulence and dry mouth mucous membranes. Occasionally, a change in the activity of liver enzymes may be noted.

Sometimes headaches, drowsiness and depression occur, and loss of consciousness may also occur.

Allergy symptoms develop with hypersensitivity to the drug elements. They appear as itching, skin rash and bronchial spasm. If the patient has such symptoms, it is necessary to stop taking Veloz.

There are isolated complaints about the development of complications such as pain in the sternum or back, myalgia, muscle cramps, hyperhidrosis, visual disturbances, weight gain, pharyngitis, decreased platelet and leukocyte counts, and in addition, infection in the urinary tract.

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Overdose

Intoxication causes the following complications: nausea, turning into vomiting, dry mouth, hyperhidrosis, a feeling of drowsiness, headache, and loss of consciousness.

There is no specific antidote; if such manifestations develop, symptomatic procedures must be performed.

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Interactions with other drugs

It is prohibited to prescribe rabeprazole with drugs that inhibit the action of hemoprotein P450, because the metabolism of the drug occurs with the participation of this system.

Veloz reduces ketoconazole levels by 33%, thereby reducing the medicinal effect of the latter.

The combination with dioxin potentiates its properties and prolongs the duration of exposure – by increasing its levels in the blood by 22%.

Rabeprazole affects the metabolism of cyclosporines.

The medication interacts with agents whose absorption rate depends on the pH level of the stomach.

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Storage conditions

Veloz should be kept in a place protected from sunlight. Temperature values should not exceed 25°C.

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Shelf life

Veloz can be used for 2 years from the date of release of the drug.

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