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Valordine
Last reviewed: 03.07.2025
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Soothing drops, watery-transparent, with a distinct aroma of valerian and menthol. The active ingredients of this drug are ethylbromisovalerianate and phenobarbital, as additional components the composition contains essential oils of peppermint and hops, ethyl alcohol and distilled water.
Indications Valordina
Short-term (no more than two weeks) therapy for painful sensations in the heart area due to neuroses, overexcitement, anxiety and sleep disorders caused in this way.
Release form
Oral drops in 25 ml dark glass bottles with dropper stoppers or in 35 (50) ml polymer bottles, placed in cardboard boxes with instructions for use included inside.
Pharmacodynamics
This drug has a calming and moderate hypnotic effect on the human body. These properties are due to the active ingredients of the drug. Ethyl bromisovalerianate has the greatest effect on the cells of the cerebral cortex, this substance causes inhibition of the processes of inhibition and excitation, as well as suppression of the activity of the spinal cord and medulla oblongata with some weakening of the function of external respiration. It exhibits a calming, anesthetic and moderate hypnotic effect, in addition - eliminates spasms of smooth muscles.
Phenobarbital is a barbiturate that, in small doses, has a sedative effect and dilates blood vessels. When dosed correctly, its hypnotic effect is virtually nonexistent.
Additional ingredients – essential oils of mint and hops – enhance the antispasmodic and vasodilating effects.
Pharmacokinetics
Not presented.
Dosing and administration
Drop 15 to 20 drops into a quarter glass of water and drink three times a day before meals; in case of insomnia, it may be recommended to increase the dosage to 30 drops. The course duration is no more than two weeks.
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Use Valordina during pregnancy
Phenobarbital is contraindicated for pregnant women because this substance is not retained by the placental barrier and is found in all tissues of the embryo, especially in the placenta, liver and brain, and can cause developmental defects.
It is not prescribed during lactation, as it is found in breast milk.
Contraindications
Sensitization to the ingredients of the drug, porphyria, age group of patients 0-17 years, pregnant and lactating women, severe liver and/or kidney failure, conditions with a high probability of seizures: epilepsy, chronic alcoholism, traumatic and other pathologies of the brain.
Side effects Valordina
Central nervous system: muscle spasms, diffuse headache and dizziness, anxiety, fatigue, hyper- (akinesia), fainting, weakness, disorientation, ataxia, irritability, depression, nightmares, insomnia and other psychoneurological disorders.
Respiratory system: respiratory failure, respiratory arrest.
Digestive organs: dyspepsia, liver dysfunction.
Hematopoiesis: decreased levels of platelets, leukocytes, B12-folate deficiency anemia.
Heart and blood vessels: decreased heart rate, hypotension, thrombophlebitis.
In addition: visual dysfunction, allergic rashes, fever.
Long-term use of phenobarbital-containing drugs causes addiction, the symptoms of which are expressed in disorientation in space, overexcitation, sleep disorders, psychosomatic disorders. Patients are reluctant to stop taking the drug, tend to increase the dose, and withdrawal may develop when discontinuing, so discontinuation after long-term use should be done gradually.
High-dose, prolonged use can lead to chronic bromism, which manifests itself as a depressed mental state, respiratory reactions, inflammation of the outer shell of the eye, lack of coordination of movements, spontaneous bleeding and hemorrhages.
It should be taken into account that the components of the drug can reduce the speed of psychomotor reactions, and also that the lethal dose of barbiturates in combination with alcohol is significantly reduced.
It should be prescribed with caution to patients with acute or chronic pain syndrome.
Overdose
The active components of the drug can cause intoxication of varying degrees of severity.
Mild and moderate acute phenobarbital poisoning is characterized by dizziness, apathy, and dead sleep. Severe poisoning is characterized by a comatose state combined with oxygen starvation of tissue cells; rapid, shallow breathing that gradually slows down, tachycardia, arrhythmia, hypotension, collapse, and very weak, fading reflexes. Lack of medical care is fatal; death occurs from paralysis of the respiratory muscles, pulmonary edema, or circulatory shock.
At the first signs of acute barbiturate poisoning, it is necessary to call an ambulance and take the patient to a hospital, where resuscitation measures will be carried out.
The development of bromine poisoning is manifested by disorientation in space, muscle weakness, apathy, respiratory symptoms, inflammation of the outer shell of the eye, bromine acne and spontaneous hematomas on the skin.
Help with bromism consists of taking a saturated solution of table salt (10-20 g) in combination with furosemide, bufenox, and diacarb.
Interactions with other drugs
Combined use with other sedatives, as well as tranquilizers and neuroleptics, mutually enhances their effect. With drugs that stimulate the nervous system, in particular, caffeine and nicotine, it weakens the effectiveness of each of them.
Drinking alcohol potentiates the effects of the drug and may lead to intoxication.
It is not advisable to combine the use of Valordin with indirect anticoagulants, antibiotics, sulfonamides, and other drugs whose metabolism occurs in the liver due to the mutual reduction in the effectiveness of these drugs.
In combination with coumarin derivatives, griseofulvin, glucocorticosteroids, and oral contraceptives, there is a mutual decrease in the effectiveness of the drugs.
Combination with methotrexate is undesirable due to increased toxicity of the latter.
When phenytoin and the Valordin component phenobarbital are used in combination, regular monitoring of the concentrations of these substances in the patient’s blood is necessary.
Valproic acid and its derivatives inhibit the metabolism of phenobarbital, and in this combination, the serum level of phenobarbital should be monitored to adjust the dosage. MAO inhibitors also inhibit the process of phenobarbital degradation.
Storage conditions
Shelf life
2 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Valordine" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.