Central nervous system: spasmodic contractions of the muscles, diffuse headache and dizziness, anxiety, fatigue, hyper- (akinesia), fainting, weakness, disorientation, ataxia, irritability, depression, nightmares, insomnia and other psychoneurological disorders.
Respiratory organs: respiratory failure, respiratory arrest.
Organs of digestion: dyspepsia, liver dysfunction.
Hemopoiesis: a decrease in the level of platelets, leukocytes, B12-folic deficiency anemia.
Heart and blood vessels: decreased heart rate, hypotension, thrombophlebitis.
In addition: visual dysfunction, allergic rashes, febrile condition.
Long-term use of drugs with phenobarbital is addictive, the symptoms of which are expressed in disorientation in space, overexcitation, sleep disorders, psychosomatic disorders. In patients, there is a reluctance to stop taking the drug, a tendency to increase the dose of the drug, withdrawal can lead to abstinence, therefore, cancellation after prolonged reception should be done gradually.
A highly dosed, long-term administration can lead to chronic bromism, which is manifested by the oppressed state of the psyche, respiratory reactions, inflammation of the outer shell of the eye, movement dissociation, spontaneous bleeding and hemorrhage.
It should be taken into account that the components of the drug can reduce the speed of psychomotor reactions, and that the lethal dose of barbiturates in combination with alcohol is significantly reduced.
Caution should be given to patients with acute or chronic pain syndrome.