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Valordin
Last reviewed: 23.04.2024
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Soothing drops, watery-transparent, with a pronounced aroma of valerian and menthol. Active ingredients of this drug - ethyl bromizovalerianate and phenobarbital, as additional components in the composition contain essential oils of peppermint and hops, ethyl alcohol and distilled water.
Indications of the valordina
Short-term (no more than two weeks) therapy of painful sensations in the heart area with neuroses, overexcitation, anxiety and sleep disorders so provoked.
Release form
Oral drops in bottles of dark glass with a volume of 25 ml with stoppers-droppers or in bottles with a capacity of 35 (50) ml of polymer material, placed in cardboard boxes with an enclosed instruction for use.
Pharmacodynamics
This drug has a soothing and moderate hypnotic effect on the human body. These properties are due to the active ingredients of the drug. Ethyl bromizovalerianate most influences the cells of the cerebral cortex, this substance causes inhibition of inhibition and excitation, as well as suppression of the activity of the spinal cord and the medulla oblongata with a certain weakening of the function of external respiration. It shows a soothing, anesthetic and moderate hypnotic effect, besides - it eliminates spasms of smooth muscles.
Phenobarbital is barbiturate, which in small doses has a sedative effect and dilates the vessels. When the dosages are observed, the hypnotic effect is practically not manifested.
Additional ingredients - essential oils from mint and hops, enhance the spasmolytic and vasodilating effects.
Pharmacokinetics
Not presented.
Dosing and administration
Drink 15 to 20 drops in a quarter of a glass of water and drink three times a day before meals; when insomnia can be recommended to increase the dosage to 30 drops. The duration of the course is not more than two weeks.
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Use of the valordina during pregnancy
The intake of phenobarbital is contraindicated in pregnant women, since this substance is not retained by the placental barrier and is found in all tissues of the embryo, especially in the placenta, liver and brain, and can cause malformations.
It is not prescribed during lactation, as it is found in breast milk.
Contraindications
Sensitization to the ingredients of the drug, porphyria, age group of patients 0-17 years, pregnant and lactating women, severe hepatic and / or renal insufficiency, conditions with high likelihood of seizures: epilepsy, chronic alcoholism, traumatic and other pathologies of the brain.
Side effects of the valordina
Central nervous system: spasmodic contractions of the muscles, diffuse headache and dizziness, anxiety, fatigue, hyper- (akinesia), fainting, weakness, disorientation, ataxia, irritability, depression, nightmares, insomnia and other psychoneurological disorders.
Respiratory organs: respiratory failure, respiratory arrest.
Organs of digestion: dyspepsia, liver dysfunction.
Hemopoiesis: a decrease in the level of platelets, leukocytes, B12-folic deficiency anemia.
Heart and blood vessels: decreased heart rate, hypotension, thrombophlebitis.
In addition: visual dysfunction, allergic rashes, febrile condition.
Long-term use of drugs with phenobarbital is addictive, the symptoms of which are expressed in disorientation in space, overexcitation, sleep disorders, psychosomatic disorders. In patients, there is a reluctance to stop taking the drug, a tendency to increase the dose of the drug, withdrawal can lead to abstinence, therefore, cancellation after prolonged reception should be done gradually.
A highly dosed, long-term administration can lead to chronic bromism, which is manifested by the oppressed state of the psyche, respiratory reactions, inflammation of the outer shell of the eye, movement dissociation, spontaneous bleeding and hemorrhage.
It should be taken into account that the components of the drug can reduce the speed of psychomotor reactions, and that the lethal dose of barbiturates in combination with alcohol is significantly reduced.
Caution should be given to patients with acute or chronic pain syndrome.
Overdose
Effective components of the drug can cause intoxication of varying severity.
The mild and moderate severity of acute poisoning with phenobarbital is manifested by dizziness, apathy, dead sleep. Severe degree - a coma in combination with oxygen starvation of tissue cells; first a shallow breathing, gradually slowing down, tachycardia, arrhythmia, hypotension, collapse, very weak fading reflexes. Lack of medical care leads to death; death comes from paralysis of the respiratory musculature, pulmonary edema or circulatory shock.
At the first signs of acute poisoning with barbiturates, it is necessary to call an ambulance and take the patient to the hospital, where he will be resuscitated.
The development of bromine poisoning is manifested by disorientation in space, muscle weakness, apathy, respiratory symptoms, inflammation of the outer shell of the eye, bromine acne and spontaneous hematomas on the skin.
The help with bromism consists in taking a saturated solution of table salt (10-20 g) in combination with furosemide, bufenox, diacarb.
Interactions with other drugs
Combined use with other sedative medications, as well as with tranquilizers and neuroleptics mutually reinforces their effect. With agents that stimulate the nervous system, in particular, caffeine and nicotine, weaken the effectiveness of each of them.
Drinking alcohol potentiates the effects of the drug and can lead to intoxication.
It is undesirable to combine the use of Valodin with indirect anticoagulants, antibiotics, sulfonamides, and other drugs, the metabolism of which occurs in the liver due to a mutual decrease in the effectiveness of these drugs.
In combination with coumarin derivatives, griseofulvin, glucocorticosteroids, oral contraceptives, there is a mutual decrease in the effectiveness of the drugs.
The combination with methotrexate is undesirable because of the increased toxicity of the latter.
With the combined use of phenytoin and Valordine-phenobarbital component, regular monitoring of the concentrations of these substances in the blood of the patient is necessary.
Valproic acid and its derivatives interfere with the metabolism of phenobarbital, with this combination of the serum level of phenobarbital should be controlled in order to adjust the dosing. Also inhibit the decomposition of phenobarbital MAO inhibitors.
Storage conditions
Shelf life
2 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Valordin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.