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Valocordin
Last reviewed: 23.04.2024
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The drug Valocordin refers to the pharmacological group of sedatives that have an effect on the central nervous system and vascular system.
Other trade names: Corvaldin, Valordin, Valoferin, Valoserdin, Lavokordin.
Indications Valocordin
Release form
Valocordin is available in the form of alcohol-containing drops (in dark glass bottles with a dropper, capacity - 20 or 50 ml).
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Pharmacodynamics
The action of the drug Valocordin is provided by its constituent components.
The barbituric acid derivative phenobarbital (5-phenyl5-ethylbarbituric acid), interacting with receptors inhibiting nerve impulses of GABA neurotransmitters, reduces the excitability of the central nervous system and thus soothes, helps to fall asleep and relaxes the muscular walls of blood vessels.
The hypnotic, sedative, and spasmolytic effects of ethyl bromoisovalerianate (a-bromisovaleric acid ester) in its mechanism-the slowing down of the passage of nerve signals-are close to the action of isovaleric acid contained in the roots of valerian drug.
Peppermint oil (menthol) irritates receptors of mucous membranes and promotes reflex vasodilation, removing vascular spasms (including coronary vessels) and reducing pain sensations.
The hip hop oil contained in the Valocordin preparation contains the ketone compound, which inhibits the central nervous system, methylnonyl ketone (butanone). As an unsafe irritant organic matter enters the ATSDR register (USA).
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Pharmacokinetics
After internal use, phenobarbital adsorbs from the gastrointestinal tract into the systemic circulation, binding to proteins is 20-45%; the maximum concentration in plasma is noted after 8-12 hours; the level of bioavailability is about 90%. Prolonged use of Valocordin leads to the accumulation of 5-phenyl 5-ethylbarbituric acid in the blood plasma.
Phenobarbital refers to long-acting barbiturates, so its effects last from four hours to two days. The half-life can be 2-7 days. Metabolized in the liver (by hydroxylation and glucuronization), metabolites are excreted mainly by the kidneys.
Concerning the pharmacokinetics of ethyl bromizovalerianate, only that the removal of this substance occurs very slowly is indicated, and this creates conditions for the cumulation of bromine and its toxic effects on the body.
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Dosing and administration
Valocordin is recommended to be taken by dissolving 18-20 drops in a small amount of water and washing the preparation with several sips of liquid. In cases of an attack of spasms, the dose can be increased by a factor of two.
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Use Valocordin during pregnancy
Use during pregnancy and lactation of this drug is contraindicated (hazard category D).
Contraindications
Valokordin is contraindicated in cases of impaired kidney and liver function, with all forms of baked porphyria (acute stage), epilepsy, craniocerebral trauma, alcohol dependence. Do not apply this drug to patients under the age of 18 years.
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Side effects Valocordin
It should be borne in mind that drops of Valocordin taken on a regular basis can lead to such undesirable actions as lowering blood pressure and heart rate; headache and fainting; nausea, vomiting and constipation; skin allergic reactions.
In addition, in case of prolonged use of Valocordin, the combined cumulative effect of phenobarbital and ethyl bromizovalerianate can provoke not only drug dependence, but also such problems on the part of the central nervous system as overexcitement, increased nervousness, deterioration of sleep and memory; violation of coordination of movements (including walking); sexual dysfunction and speech disorders.
A depressive condition, the appearance of inflammation of the mucous membranes of the nose and conjunctiva, as well as increased bleeding of the skin (in the form of hemorrhagic diathesis) may indicate the accumulation of bromine in the body.
Overdose
In case of an overdose, Valocordin causes intoxication of varying severity - from dizziness and falling BP to apnea and coma, requiring urgent resuscitative measures.
In mild cases of bromide poisoning, it is sufficient to rinse the stomach and ingest the solution of table salt and diuretics of the thiazide group.
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Storage conditions
Drops Valocordin should be stored in a dark place at room temperature.
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Shelf life
Attention!
To simplify the perception of information, this instruction for use of the drug "Valocordin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.