Ganglerone

Gangleron belongs to the antispasmodic drugs of the anticholinergic group – blockers of n-cholinergic receptors of the ganglia of the autonomic nervous system and the central nervous system.

Other names: Ganglefen, Ganglefen hydrochloride.

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Indications Ganglerone

Gangleron is used for such diseases as:

• acute and chronic cholecystitis,
• cholangitis,
• hepatitis,
• gastric ulcer and duodenal ulcer,
• dyskinesia of the digestive organs with spasms, gastrointestinal motility disorder,
• damage to the nodes of the sympathetic trunk of various localizations (ganglioneuritis, ganglionitis),
• angina (to prevent attacks).

Release form

Gangleron is available in the form of capsules (0.04 g) and as a solution (1.5%) for injection (in 2 ml ampoules).

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Pharmacodynamics

The active substance of the ganglionic blocker Gangleron is 3-diethylamino-1,2-dimethylpropyl ether parabutoxybenzoic acid in the form of hydrochloride. It prevents the effect of acetylcholine on nicotine-sensitive receptors (n-cholinergic receptors) of the autonomic nerve nodes (ganglions) located on their membranes and disrupts the process of polarization and excitation of postganglionic neurons.

As a result, there is a delay in the passage of nerve impulses from peripheral organs through the ganglia to the central nervous system, which, in turn, suppresses their functions (including motor and secretory). At the same time, reflex spasms of smooth muscle tissues of organs and vessel walls are removed.

In addition, Gangleron promotes vasodilation and a reduction in their peripheral resistance to blood flow, which reduces systolic blood pressure.

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Dosing and administration

Gangleron capsules are taken orally - one capsule three times a day (before meals): the maximum daily dose is 0.3 g.

The injection solution is administered intramuscularly or subcutaneously – 4 ml; the maximum daily dose is 12 ml.

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Use Ganglerone during pregnancy

Not provided.

Contraindications

Contraindications to the drug Gangleron include renal and hepatic insufficiency, vascular hypotension, decreased gastrointestinal motility, atony of the bladder, glaucoma, thrombosis, and childhood.

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Side effects Ganglerone

The use of Gangleron can cause general weakness, dizziness, orthostatic drop in blood pressure, increased heart rate, dry mouth, constipation, decreased tone of the bladder muscle walls, impaired accommodation, and dilated pupils.

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Overdose

Although ganglionic blockers in large doses can cause respiratory depression, the instructions for Gangleron indicate that there is no information on cases of its overdose.

Interactions with other drugs

Not specified.

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Storage conditions

Gangleron should be stored at room temperature, in a dark place.

Shelf life

Gangleron in capsules – 24 months, in ampoules – 36 months.