Gangleron

Gangleron refers to antispasmodics of the group of anticholinergics - blockers of n-cholinergic receptors of the ganglion of the autonomic nervous system and the central nervous system.

Other names: Ganglefen, Ganglefen hydrochloride.

[1], [2], [3]

Indications Gangleron

Gangleron is used for such diseases as:

• acute and chronic cholecystitis,
• cholangitis,
• hepatitis,
• peptic ulcer of the stomach and duodenum,
• dyskinesia of the digestive system with spasms, a violation of the motility of the gastrointestinal tract,
• defeat of the nodes of the sympathetic trunk of different localization (ganglionvrit, ganglionitis),
• angina (to prevent seizures).

Release form

Gangleron is available in the form of capsules (0.04 grams) and as a solution (1.5%) for injections (in 2 ml ampoules).

[4], [5], [6]

Pharmacodynamics

The active substance of the ganglionic Gangleron -3-diethylamino-1,2-dimethylpropyl ester, parabutoxybenzoic acid in the form of hydrochloride, prevents the effect of acetylcholine on the nicotinic receptors (n-cholinergic receptors) of autonomic nerve nodes (ganglia) located on their membranes and disrupts the process of polarization and excitation postganglionic neurons.

As a result, the passage of nerve impulses from peripheral organs through the ganglia to the central nervous system occurs, which in turn inhibits their functions (including motor and secretory ones). At the same time, reflex spasms of the smooth muscle tissues of the organs and walls of the vessels are removed.

In addition, Gangleron promotes vasodilation and a reduction in peripheral resistance to blood flow, which reduces systolic blood pressure.

[7], [8]

Dosing and administration

Ganglionone in capsules is taken orally - one capsule three times a day (before meals): the maximum daily dose is 0.3 g.

Solution for injection is injected intramuscularly or subcutaneously - 4 ml; the maximum daily dose is 12 ml.

[11]

Use Gangleron during pregnancy

Not provided.

Contraindications

Among the contraindications of the drug Gangleron, renal and hepatic insufficiency, vascular hypotension, decreased motility of the gastrointestinal tract, atony of the bladder, glaucoma, thrombosis, children's age are noted.

[9]

Side effects Gangleron

The use of Gangleron may cause general weakness, dizziness, orthostatic BP depression, increased heart rate, dry mouth, constipation, decreased tonus of the muscular walls of the bladder, accommodation disorder, dilated pupils.

[10]

Overdose

Although gangliobloktorav in large doses can cause respiratory depression, Gangleron's instructions indicate that there are no cases of his overdose.

Interactions with other drugs

Not specified.

[12], [13], [14],

Storage conditions

Ganglerone should be stored at room temperature, in a dark place.

Shelf life

Gangleron capsules - 24 months, in ampoules - 36 months.