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Validol
Last reviewed: 23.04.2024
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Validol is a combined sedative and is included in the pharmacological group of psycholeptics - soothing drugs. In fact, this drug refers to drugs for the treatment of diseases of the nervous system.
Validol also has a reflex effect of vasodilation (reduces the tone of the vascular walls and promotes the widening of the lumen of the vessels), and on this basis this drug has the code C01EX (other combination drugs for the treatment of heart diseases). However, it should be borne in mind that according to the mechanism of action, Validol is not a cardiopreparation and relieves pain spasm without treatment of myocardial ischemia.
Other names: Korvalment, Kormenthal, Valofin, Menthoval, Menthylisovalerat.
Indications Validol
In the first place, Validol is prescribed for the treatment of anxiety disorders and panic attacks; This symptomatic remedy can also be used for neurasthenia, uncontrolled hysterical states, neurocirculatory dystonia, kinetosis (nausea in motion sickness in transport), pain in the heart (caused by cardiovascular reflexes that occur in various psychoemotional states).
The instructions indicate that with the help of Validol, you can stop an attack of angina, but in cardiology, antianginal drugs of the nitrate group (nitroglycerin, etc.) are used for this.
Pharmacodynamics
Farmakodinamiku Validol provides its active substance - a solution of menthol in the methyl ester of isovaleric (3-methylbutanoic acid), which acts on the plasma membranes of the cells of the oral mucosa and stimulates its nerve receptors according to the principle of allosteric modulation of enzyme metabolism.
In response to stimulation of the receptors, synthesis of endogenous polypeptide neurotransmitters is increased after a few minutes. In particular, opioid peptides endorphin and enkephalin stabilize the emotional state (soothe) and reduce epicritic pain (with angina pectoris); Bradykinin dilates blood vessels (including coronary vessels), etc.
[3]
Dosing and administration
A tablet or capsule of Validol should be placed under the tongue; the drug in liquid form is applied five drops per piece of sugar, which (as in the case of a tablet) should be kept in the mouth until it is completely absorbed.
The maximum daily dose is 200-240 mg.
[7]
Use Validol during pregnancy
Use during pregnancy is considered permissible. But it should be borne in mind that menthol to pregnant women is contraindicated (in official instructions to Validol about it is held back), as the use of essential oil of mint affects the level of sex hormones.
Contraindications
Validol is contraindicated in case of intolerance to menthol, low blood pressure, acute violation of cerebral circulation (stroke).
Not applicable Validol in childhood (up to 12 years).
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Overdose
Exceeding the daily dose of Validol causes CNS depression, nausea and vomiting.
[8]
Storage conditions
Validol is recommended to store at a temperature of + 15-20 ° C.
[12],
Shelf life
4 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Validol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.