Urosept

Urological antiseptic – suppositories Urosept – is a representative of antibacterial drugs of the quinolone group.

Indications Urosepta

Urosept suppositories are usually prescribed for the treatment of inflammatory infectious pathologies that were provoked by bacteria sensitive to the drug - for example, this could be an inflammatory process in the urethra, in the bladder, in the prostate gland, or in the kidneys.

Release form

Urosept is produced in the form of suppositories of a whitish-yellowish hue, with a possible slight coating on the surface.

The active ingredient of Urosept is pipemidic acid.

The package contains ten suppositories, sealed in blister packs of five pieces.

Pharmacodynamics

Urosept suppositories belong to the group of antiseptic agents of the quinolone series.

Urosept has a high-quality bactericidal effect, especially against gram-negative microbes, as well as against individual gram-positive bacteria (for example, Staphylococcus aureus).

Pharmacokinetics

The maximum possible level of Urosept in the blood serum is detected 2-3 hours after using the drug. Such a maximum level is simultaneously detected in the urine.

The ingredients of Urosept are excreted from the body through the urinary system unchanged.

Dosing and administration

Before you start using Urosept, you need to perform a series of sequential steps:

• along the perforated line of the blister, it is necessary to separate one suppository from the common plate;
• After this, you should tear the edges of the film and release the candle.

Urosept can be used both rectally in the rectum and intravaginally in the vagina: 1 piece twice a day, for ten days in a row.

If necessary, the daily amount of Urosept can be increased to 3 suppositories (morning, afternoon and night).

Use Urosepta during pregnancy

It is not permitted to use Urosept suppositories during pregnancy or while breastfeeding.

Contraindications

Urosept suppositories should not be used if you are prone to an allergic reaction to the components of the drug, in severe kidney pathologies (creatinine clearance less than 10 ml per minute), in severe liver diseases (cirrhosis), in CNS pathologies (epilepsy, decreased seizure threshold).

Side effects Urosepta

Side effects include local and systemic manifestations:

• irritation of the mucous membranes, pain and burning in the area where the Urosept suppository was inserted;
• development of anemia, eosinophilia, thrombocytopenia;
• state of excitement, depression, hallucinations;
• trembling in the arms and legs, insomnia, sensory disturbances, convulsions, headaches;
• visual impairment;
• allergic reactions – rash, itching, photosensitivity;
• joint pain, tendinitis;
• weight loss, abdominal pain, heartburn, nausea, bloating, diarrhea or constipation;
• feeling of weakness;
• formation of resistance, development of superinfection.

If the side effects are severe, Urosept treatment should be discontinued. First of all, this applies to cases with allergic processes, as well as with the development of toxic epidermonecrolysis.

Overdose

Signs of a possible overdose of Urosept may include:

• attacks of vomiting and nausea;
• dizziness, impaired consciousness;
• trembling in the limbs and fingers, muscle cramps.

If the patient who suffered an overdose is conscious, it is necessary to wash out his stomach and give him a sufficient amount of sorbent drugs.

In severe cases, hemodialysis may be used, which is 90% effective within six hours.

If the patient has CNS disorders, such as seizures, then symptomatic treatment with diazepam is appropriate.

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Interactions with other drugs

If treatment with Urosept is prolonged, the half-life of theophylline may be extended due to an increase in its content in the blood to 40-80%.

Urosept increases plasma caffeine content (increase factor 2-4).

Urosept can potentiate the action of such medications as Warfarin, Cimetidine, Rifampicin.

When combining Urosept and non-steroidal anti-inflammatory drugs, the likelihood of developing a convulsive syndrome may increase.

Antacid agents and Sucralfate impair the absorption of Urosept, so the interval between taking such drugs should be about 2.5 hours.

Combination with aminoglycosides results in a synergistic antimicrobial effect.

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Storage conditions

Urosept suppositories are stored in normal room conditions, out of reach of children, away from sunlight and heating devices. The optimal temperature for storage is from +20 to +24°C.

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Shelf life

Urosept can be stored for up to 3 years.