Possible development of the following undesirable effects associated with therapy with this drug.
Organs of digestion: indigestion, a feeling of dryness in the oral cavity, gastroduodenal hemorrhages (isolated cases).
Nervous system and psyche: dizziness, asthenia, agitation, headache, drowsiness, insomnia, increased anxiety, static or dynamic ataxia, trembling in the extremities, extrapyramidal disorders. Single cases of development of convulsive, manic and serotonin syndrome, hallucinations, paresthesias and taste distortion are known.
Allergic manifestations: urticaria, rashes, itching, hypersensitivity to ultraviolet radiation, angioedema.
Heart and blood vessels: arrhythmia, minor bradycardia, tachycardia, orthostatic hypotension.
Other: galactorrhea, myalgia, arthralgia, hyperhidrosis, purpura, ejaculation, lack of orgasm, weight loss, urination disorders, development of hyponatremia (passes after cancellation).
The drug is addictive. The medication is stopped, gradually reducing the dose, a sudden discontinuation may cause withdrawal symptoms: nausea, dizziness, paresthesia, increased anxiety and headache.
Suicidal intentions, often accompanying depressive disorders, can persist for a long time before a sufficient remission (such patients should be regularly monitored).
Symptoms of serotonin syndrome (extremely rarely developing) are expressed in hyperthermia, muscular rigidity, mental disorders, lability in the autonomic nervous system, development of coma.