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Urorek
Last reviewed: 03.07.2025
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The encapsulated drug Urorek belongs to the group of α-adrenergic receptor antagonists, with the main active ingredient silodosin.
Release form
Urorek is produced in the form of dense capsules, containing 4 or 8 mg of the active ingredient silodosin.
The packaging may include one, three, five or nine blister plates, with 10 capsules in each plate.
Pharmacodynamics
The active ingredient Urorek is a highly selective competitive α 1a -adrenoreceptor antagonist. Silodosin provides blockade of postsynaptic α 1a -adrenoreceptors, which are localized in the smooth muscle structures of the prostate and urinary system.
Urorek reduces the tone of the smooth muscles of the prostate, which leads to easier outflow of urine. Along with such processes, signs of infringement and irritation caused by benign proliferation of prostate tissue are eliminated.
The affinity for α 1a -adrenoreceptors, which are located in the bladder, is 162 times greater than its ability to interact with α 1b -adrenoreceptors, localized in the smooth muscle structures of blood vessels.
As a result of its high selectivity, Urorek does not produce a clinically important reduction in blood pressure in individuals with normal blood pressure values.
Pharmacokinetics
After oral administration, Urorek is well absorbed in the digestive system. Complete bioavailability is estimated at 32%. Food masses in the stomach can reduce the maximum concentration by 30%, increasing the time to reach peak content to 60 minutes.
The distribution volume of the active ingredient Urorek is close to 0.81 liter/kg. The binding of silodosin to plasma proteins is 96.6%, while the binding of the metabolite can be 91%.
The active ingredient Urorek is metabolized by glucuronidation, with the participation of such components as alcohol dehydrogenase and aldehyde dehydrogenase.
The active major metabolite in serum is considered to be carbamoyl glucuronide, which approaches serum concentrations 4 times higher than silodosin. However, the active ingredient has no induction potential and does not inhibit cytochrome P450 isoenzymes.
Most of the active ingredient Urorek (almost 55%) is excreted from the body with feces, and a smaller part (more than 33%) with urine.
The main amount of the active ingredient Urorek is excreted as residual metabolic products, and a small amount in unchanged form.
The half-life of the active ingredient and metabolite is estimated to be 11 h and 18 h, respectively.
Dosing and administration
Urorek is used only for the treatment of adult male patients. The standard daily dose of the drug is 8 mg at a time. In some cases, a dosage of 4 mg once a day may be prescribed.
Urorek is taken with food, preferably at the same time every day.
The Urorek capsule must not be damaged or crushed: it must be swallowed whole with a glass of water.
For the treatment of elderly patients, the same dosage is used, which does not require adjustment.
In case of kidney disease, correction is also not required. The exception is severe renal pathologies, with creatinine clearance less than 30 ml per minute: in such circumstances, Urorek should not be used.
In case of liver pathologies, treatment with Urorek is not recommended only in severe forms of the disease.
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Use Uroreka during pregnancy
Urorek is not intended for use by female patients.
Contraindications
You should not take Urorek if you are prone to allergic reactions to the ingredients of the medication.
Side effects Uroreka
The most common side effects during the use of Urorek are ejaculation disorders - in particular, deterioration or complete absence of ejaculation. The frequency of such disorders is 23%, but they are transient and disappear after the discontinuation of treatment with Urorek.
Less frequently, other undesirable side effects may also be observed:
- decreased sexual desire;
- dizziness;
- increased heart rate;
- lowering blood pressure;
- feeling of nasal congestion;
- diarrhea, thirst, nausea;
- laboratory changes in liver function tests;
- erectile dysfunction.
Overdose
The potential for overdose has been studied with up to 48 mg of Urorek per day in males. The main symptom was a sharp drop in blood pressure.
If Urorek was taken in an increased dose relatively recently, then vomiting should be induced in the victim or the stomach should be washed. In case of severe hypotension, measures should be taken to ensure normal functioning of the cardiovascular system.
Dialysis is not used in this case, since the active ingredient Urorek almost completely forms bonds with plasma proteins (more than 96%).
Interactions with other drugs
Urorek should not be combined with other drugs from the α-blocker group to avoid possible mutual enhancement of effects.
Concomitant administration of drugs that inhibit the CYP3A4 isoenzyme (such as Ketoconazole, Ritonavir, Clarithromycin, Itraconazole) is undesirable due to an increase in the concentration of silodosin in the serum.
Combining Urorek with phosphodiesterase inhibitors (eg, Sildenafil or Tadalafil) may cause dizziness.
Medicines with hypotensive activity, calcium antagonists, agents affecting the renin-angiotensin-aldosterone system, as well as diuretics in combination with Urorek can accelerate and worsen the development of hypotension.
When using Urorek along with digoxin preparations, there is no need to adjust the dosage.
Storage conditions
Urorek is stored in the original packaging, in a dark, dry place, at a maximum temperature of up to +30°C. Children should not be allowed near places where medicines are stored.
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Shelf life
Urorek can be stored for up to 3 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Urorek" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.