Ulsepan

Ulsepan is a medicine that successfully helps to fight gastrointestinal ulcers. The drug has a pronounced antisecretory effect. Ulsepan has a second, non-proprietary name - pantoprazole. As a representative of the group of proton pump inhibitors, it is one of the effective drugs for the treatment of ulcerative colitis. The drug is also intended for the treatment of diseases associated with acidity disorders in the gastrointestinal tract.

Indications Ulsepan

Ulsepan is suitable for use in adults and children over twelve years of age in case of reflux esophagitis.

For adults, indications for the use of Ulsepan also apply to the following diseases:

• stomach ulcer;
• duodenal ulcer;
• pathological hypersecretory diseases;
• gastroesophageal disease;
• erosive-ulcerative - reflux esophagitis;
• ulcerative lesions of the gastrointestinal tract due to the use of non-steroidal drugs.

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Release form

The medicine is biconvex tablets, which are covered with a yellow enteric coating. The release form assumes oval-shaped tablets. Each tablet contains 40 mg of the therapeutic drug - pantoprazole, which is the required daily dose of the drug. It can be released in two forms - two or four blasters (plates). Each blaster contains seven tablets.

Pharmacodynamics

Ulsepan is one of the antiulcer drugs that works due to the antisecretory effect of lantprasor. The process of inhibition of the proton pump occurs. Pharmacodynamics of Ulsepan involves the accumulation of lantraprazole among the tubules of parietal cells. Interaction with hydrogen ions occurs. Then the drug transforms sulfenamide production reactions, covalent bonds are formed with the proton pump group on the surface of the apical membrane.

As a result of these processes, the last phase of hydrochloric acid secretion is blocked and the level of acid secretion in the stomach decreases.

Pharmacodynamics Ulsepan has antibacterial activity, which contributes to the anti-Helicobacter effect of other medications used by the patient.

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Pharmacokinetics

After the drug enters the stomach, Ulsepan is absorbed in the gastrointestinal tract within a few minutes. The percentage of bioavailability is up to 80%. The maximum concentration of the tablet occurs after 4 hours. The first period of elimination occurs within one hour. Pantoprazole tablets penetrate the blood-brain barrier to a small extent.

The pharmacokinetics of Ulsepan are not altered by antacid medications.

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Dosing and administration

The drug is taken orally, an hour before meals, with a sufficient amount of water. It is not recommended to take the drug with food, or simultaneously with any other medication.

One Ulsepan tablet contains 40 mg of the active drug – one daily dose. In some cases, the dose may be doubled according to a doctor’s special prescription.

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Use Ulsepan during pregnancy

There are no trials on the use of the drug during pregnancy. There are no data on the use of pantoprazole in pregnant women and subsequent abnormalities.

Studies conducted with pregnant animals have shown reproductive toxicity.

However, the use of Ulsepan during pregnancy is not recommended, except as prescribed by a doctor in cases of obvious urgent need.

Contraindications

The medication is not recommended for use in case of hypersensitivity to pantoprazole and one of the auxiliary drugs. Before starting the treatment, the attending physician should be informed about any medications that the patient is taking to avoid a negative reaction in the body to the components of various drugs.

Contraindications to the use of Ulsepan include a ban on taking the drug in case of hepatitis and liver cirrhosis, which is accompanied by acute renal failure.

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Side effects Ulsepan

Side effects after taking Ulsepan occur in approximately 5% of patients. The most common symptoms that may occur are diarrhea and headache.

When taking Ulsepan, the following side effects may occur:

• Uncommon side effects include sleep disturbance, headache, dizziness, flatulence, constipation, dry mouth, abdominal discomfort, eczema, asthenia, fatigue.
• Rare side effects include increased receptor sensitivity, changes in body weight, urticaria, myalgia, gynecomastia, increased body temperature, and peripheral edema.
• Very rare side effects include disturbances in body orientation, thrombocytopenia, and leukopenia.

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Overdose

There is no data on drug overdose. However, the side effects may increase. If one of the symptoms of drug overdose appears, you should immediately consult your doctor, describing the symptoms in detail and naming the period and exact doses of Ulsepan. Treatment is symptomatic. To enhance the effect of treatment, it is necessary to carry out the usual detoxification measures.

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Interactions with other drugs

When taking Ulsepan with other drugs that depend on the pH of the stomach, their absorption and effectiveness may decrease. No negative interactions of Ulsepan with other drugs have been identified when taken:

• Cardiac glycosides and calcium channel blockers, beta-blockers
• Antacids, antibiotics for the gastrointestinal tract
• Oral contraceptives
• Non-steroidal anti-inflammatory drugs
• Taking glibencamide and levothyroxine
• Diazepam
• Carbamazeline, phenytoin
• Indirect anticoagulants

There is also no information on interactions with caffeine, standard and theophylline.

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Storage conditions

The drug should be stored in a dry, dark place. Storage conditions for Ulsepan provide for a maximum temperature of 25°C. It is imperative to provide a place that will be reliably protected from children. Also, the storage place for Ulsepan should be dry and reliably protected from moisture.

Special instructions

Analogues

At the moment, the pharmacology market has developed a sufficient number of antiulcer drugs that have an antisecretory effect. However, the closest in composition and active drug are the following tablets and pills: Zovanta, Zolopant, Kontrolok, Nolpaza, Panocid, Pantaz, Pantasan, Panto Zentiva, Pantokar, Pantokar, Pantoprazole, Panum, Proxium, Protera and Pulzet.

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Shelf life

The shelf life of Ulsepan is two years from the date of manufacture. If all storage conditions of Ulsepan are met, the drug does not lose its medicinal properties. If the temperature at which the drug must be stored has been exceeded for a long time, the humidity in the room is high, or the seal of the package has been broken, the shelf life of Ulsepan is reduced. You should always look at the date of manufacture and the expiration date of Ulsepan before taking it to avoid the negative impact of the components on the human body, poisoning or overdose.

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