Ulsepan

Ulsepan is a medicine that successfully helps to fight the ulcer of the gastrointestinal tract. The drug has a pronounced antisecretory action. Ulsepan has a second, non-proprietary name - pantoprazole. Being a representative of a group of proton pump inhibitors, is one of the effective drugs for the treatment of ulcerative colitis. The drug is also designed to treat diseases that are associated with a violation of acidity in the gastrointestinal tract.  

Indications Ulsepan

Ulsepan is suitable for adults and children over 12 years of age in case of reflux esophagitis.

For adults, indications for use by Ulsepan are also spread in cases of the following diseases:

• stomach ulcer;
• duodenal ulcer;
• pathological hypersecretory diseases;
• gastroesophageal disease;
• erosive-ulcerative - reflux esophagitis;
• ulcerative lesions of the gastrointestinal tract, due to admission; non-steroidal medicines.

[1], [2], [3], [4]

Release form

The medication is a biconvex tablet that is coated with an enteric-soluble yellow coating. The form of the release involves oval-shaped tablets. Each tablet contains 40 mg of the medicinal medicine - pantoprazole, which is the necessary daily dose of the medication. It can be produced in two forms - two or four blasters (plates). Each blaster has seven tablets. 

Pharmacodynamics

Ulsepan is one of the antiulcer drugs that works thanks to the antisecretory effect of the lanthopper. There is a process of inhibition of the proton pump. Pharmacodynamics of Ulsepan suggests the accumulation of lantoprazole among the tubules of parietal cells. There is interaction with hydrogen ions. Further, the drug transforms the sulfenamide production reactions, covalent bonds are formed with the group of the proton pump on the surface of the apical membrane.

As a result of these processes, the last phase of hydrochloric acid secretion is blocked and the level of acid secretion in the stomach decreases.

Pharmacodynamics Ulsepan conducts antibacterial activity, which contributes to the anti-Helicobacter effect of other medications used by the patient. 

[5], [6], [7], [8], [9]

Pharmacokinetics

After the medication enters the stomach, Ulsepan is absorbed for several minutes in the gastrointestinal tract. The percentage of bioavailability is up to 80%. The maximum concentration of the tablet occurs after 4 hours. The first withdrawal period takes place within one hour. Tablets pantoprazole to a small degree penetrate the blood-brain barrier.

Pharmacokinetics Ulcepan does not change under the influence of antacid medicines. 

[10], [11], [12], [13], [14], [15],

Dosing and administration

The drug is taken orally, one hour before a meal, with plenty of water. The drug is not recommended for taking with food, as well as simultaneously with any other medical product.

One tablet of ulsepana contains 40 mg of working medicine - one daily dose. In some cases, according to a special doctor's instructions, the dose can be doubled. 

[22], [23], [24]

Use Ulsepan during pregnancy

Tests on the use of medication during pregnancy of women were not conducted. Data on the use of pregnant pantprazole and subsequent anomalies are absent.

According to the results of studies that were conducted with pregnant animals, reproductive toxicity was observed.

However, it is not recommended to use Ulcepan during pregnancy, except for the prescription of the doctor in cases of obvious acute necessity. 

Contraindications

It is not recommended to take the medication in case of hypersensitivity to pantoprazole and one of the auxiliary preparations. Before the beginning of the reception, the doctor should be informed about any medications that the patient takes to avoid a negative reaction in the body of the components of various drugs.

Contraindications to the use of Ulsepan include the prohibition of taking medication for hepatitis and cirrhosis, which is accompanied by acute renal failure. 

[16], [17], [18], [19], [20]

Side effects Ulsepan

The occurrence of side effects after taking Ulsepan manifests itself in about 5% of patients. The most common symptoms that can manifest themselves are diarrhea and headache.

When taking Ulsepan, the following side effects may occur:

• Infrequent side effects - sleep disorder, headache, dizziness, flatulence, constipation, dry mouth, discomfort in the abdomen, eczema, asthenia, fatigue.
•  Rare side effects - increased sensitivity of receptors, change in body weight, urticaria, myalgia, gynecomastia, fever, peripheral edema.
• Very rare side effects - violations of the orientation of the body, thrombocytopenia, leukopenia. 

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Overdose

There is no evidence of an overdose of the drug. But, there may be an increase in the effect of side effects. When one of the symptoms of drug overdose manifests, it is necessary to consult an attending physician immediately, describing the symptoms in detail and calling the period and exact doses of Ulsepan. Treatment is symptomatic. To enhance the effect of treatment, it is necessary to perform usual detoxification measures.
 

[25], [26]

Interactions with other drugs

With the simultaneous administration of Ulsepan with other drugs that depend on the pH of the stomach, there may be a decrease in their absorption and a decrease in efficacy. There was no negative Ulsepan interaction with other drugs, when taking:

• Cardiac glycosides and calcium channel blockers, beta-blockers
• Antacids, antibiotics for the digestive tract
• Oral contraceptives  
• Non-steroidal anti-inflammatory drugs
•  Admission of glibencamide and levothyroxine
• Diazepam
• Carbamazelin, phenytoin
• Indirect anticoagulants

There is also no information on the interaction with caffeine, etalon and theophylline.  

[27], [28], [29], [30], [31], [32]

Storage conditions

The drug should be stored in a dry, dark place. Storage conditions of Ulsepan provide a maximum temperature of 25 ° C. Be sure to provide a place that will be reliably protected from children. Also, the storage area of Ulsepan should be dry and well protected from moisture.

Special instructions

Analogues

At the moment, a sufficient number of antiulcer drugs have been developed on the market of pharmacology, which have a antisecretory effect. However, the following tablets and pills: Zovanta, Zolopent, Control, Nolpaz, Panocid, Pantaz, Pantasan, Panto Zentiva, Pantokar, Pantokar, Pantoprazole, Panum, Proxium, Protera and Pulcet are the closest in composition and active preparation.  

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Shelf life

The shelf life of Ulsepan is two years, from the date of manufacture. Under all conditions of storage of Ulsepan, the drug does not lose its medicinal properties. If the temperature for which the product is stored for a long time, high humidity in the room or the sealing of the package is exceeded, the shelf life of the Ulsepan is shortened. You should always look at the manufacturing date and shelf life of Ulsepan before taking it to avoid the negative effects of components on the human body, poisoning or overdose.

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