Treatment of cystitis in women and men with metronidazole

Manifestations of cystitis (pain in the lower abdomen, cramps when urinating, frequent urging to the toilet) cannot be ignored, it should be treated. The most common cause of the disease are infectious pathogens - gram-positive and gram-negative enterobacteria, fungi, viruses, and hypothermia, injury, hormonal disorders, and vitamin deficiencies are the impetus for their development. One of the effective drugs of antibacterial action is metronidazole. Can it be used to treat inflammation of the bladder mucosa and does it help with cystitis?

Indications Metronidazole

Under the action of the drug are infections caused by a large group of organisms that are sensitive to it, called aero-organisms, including those resulting from surgery. They are treated with urogenital trichomoniasis, giardiasis, amebic dysentery, nonspecific vaginitis. Successfully used the tool and urinary tract infections.

[1]

Release form

Metronidazole is produced in tablets, suppositories, gels. Usually it is prescribed in tablet form for oral administration, but other forms are included in the treatment of cystitis in women. This is caused by the special physiological structure of their urinary organs: the urethra is located in close proximity to the anus, it is short and wide, and therefore vulnerable to the penetration of E. Coli. The introduction of a gel or suppository into the vagina speeds up the healing process.

[2], [3]

Pharmacodynamics

The mechanism of action of the drug is based on the suppression of the DNA of bacteria, which prevents their reproduction, as well as a violation of the transmission of electronic signals in the neurons on which their respiratory process is based. As a result, they are dying.

[4], [5], [6], [7], [8]

Pharmacokinetics

Once in the body, metronidazole creates high concentrations in tissues and biological fluids. Just an hour after taking 80% of the substance is absorbed into the blood. The average half-life is 10 hours. Metabolism is carried out in the liver by oxidation. It is excreted mainly by the kidneys (the urine turns brown in this case), partly with feces.

[9], [10], [11]

Use Metronidazole during pregnancy

Studies on the effect of the drug on the development of the fetus during pregnancy were carried out only on animals and did not reveal its teratogenic effect. Probably, to give a clear answer regarding people, additional observations are needed. It is believed that if there is a real threat to the life of the future mother, it can still be used and this is decided by the doctor.

Metronidazole penetrates into breast milk, which becomes an obstacle to its appointment during breastfeeding. Another option is to stop lactation at the time of treatment.

Contraindications

Metronidazole is not prescribed or immediately discontinued in case of an allergic reaction to it. It is contraindicated in children under 6 years of age, pregnant, lactating mothers.

[12], [13]

Side effects Metronidazole

This antimicrobial agent can cause adverse reactions from many human systems and organs, including:

• digestive tract (nausea, epigastric pain, exacerbation of pancreatitis);
• skin (rash, itching, swelling);
• nervous system (dizziness, headache, seizures in some cases);
• loss of visual acuity, hearing loss, tinnitus;
• psyche (depression, hallucinations);
• irregularities in the blood count.

The appearance of one of the symptoms - a signal of dose adjustment or cancel it with the replacement of other drugs.

Dosing and administration

The dose of drug treatment is determined by the doctor individually, depending on the severity of the disease, other features of the body. Usually it is 1 tablet (250mg), 2 times a day. If necessary, the intensity of treatment is increased up to 3 times with intervals between doses of the drug for at least 8 hours.

For women, the treatment with metronidazole for cystitis can be supplemented with suppositories or gel in the first 2 days of therapy (morning and evening). Before their use, hygiene procedures are required.

Treatment of children with a drug is carried out with a dose calculated by the formula of 30-40 mg per kilogram of body weight in 2-3 doses.

How much do metronidazole drink with cystitis? The time of therapy takes up to 10 days, it is impossible to exceed this period.

[14], [15]

Application for children

Children under 6 years old are not prescribed. For older age, the dosage is calculated based on body weight.

[16], [17], [18], [19], [20], [21], [22], [23]

Overdose

Excess single dose several times causes an overdose, the symptoms of which are expressed in nausea, a violation of the coordination of movements of various muscles, disorientation in space.

[24], [25], [26], [27]

Interactions with other drugs

Metronidazole is not recommended at the same time to take with drugs based on alcohol and the alcoholic beverages themselves, because it causes tachycardia, hot flashes, vomiting.

Anticonvulsants, which induce enzymes, rifampicin (an antibiotic), lead to a decrease in serum concentrations of the drug, and its lithium increases.

Joint reception with disulfiramom, intended for the treatment of alcoholism, causes confusion, and with fluorouracil (used for cancer) increases the toxicity of the latter.

[28], [29], [30]

Storage conditions

Metronidazole in all forms is stored in its original packaging in the usual conditions for medical preparations (temperature not higher than +25 ⁰ C, away from children and sunlight).

[31], [32]

Shelf life

Tablets are stored for 3 years, suppository and ointment two.

[33], [34]

Analogs

The antibacterial drugs that have a similar effect include: metrogyl, trihopol, efloran, orzol, tinidazole, etc.

[35], [36], [37]

Reviews

Reviews of people treated with metronidazole indicate the effectiveness of the drug in the fight against cystitis. Improvement was observed literally 2-3 days after the start of therapy.

[38], [39], [40]