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Tibinil p500
Last reviewed: 04.07.2025
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Tibinil p500 belongs to the medicinal subgroup of second-line anti-tuberculosis drugs.
In case of prescribing therapy using the specified drug, it is necessary to take into account that monotherapy can provoke rapid development of pronounced resistance to it in tuberculosis mycobacteria. In this regard, the drug is usually used in combination with other anti-tuberculosis substances. [ 1 ]
Indications Tibinil p500
It is used for all types of tuberculosis (as part of combination treatment).
Release form
The medicinal element is released in tablets.
Pharmacodynamics
The medicine penetrates into the foci of tuberculosis lesions without complications. The therapeutic effect is not weakened by the acidic environment of caseous masses, which allows the drug to be used in cases of caseous lymphadenitis, as well as caseous-pneumonic infections and tuberculomas. [ 2 ]
Pharmacokinetics
Pyrazinamide is almost completely absorbed in the gastrointestinal tract. After oral administration of 1 g of the substance, its plasma level is 45 mcg/ml (after 2 hours) and 10 mcg/ml (after 15 hours).
Tibinil p500 undergoes hydrolysis to form the active metabolic element pyrazinoic acid. It is then transformed into an inactive metabolite. [ 3 ]
The half-life of the drug with healthy renal function is 9-10 hours. Pyrazinamide is excreted by the kidneys by 70%. Excretion occurs over a period of 24 hours (most of it in the form of metabolic components).
Dosing and administration
For individuals over 15 years of age and adults, the medication is administered in doses of 20-35 mg/kg (in 1-3 doses, after meals).
The medicine can be used in a dosage of 90 mg/kg once a week or in a portion of 2-2.5 g, 3 times a week. In addition, a dosage of 3-3.5 g can be used, 2 times a week, taking into account the patient's weight (for a weight below 50 kg, the portion is 165-1500 mg, and for a weight over 50 kg - 2000 mg).
The daily dose for people weighing less than 50 kg and over 60 years of age is 1.5 g. A child can take a maximum of 1.5 g of the medicine per day.
- Application for children
Not for use by persons under 15 years of age.
Use Tibinil p500 during pregnancy
It is prohibited to prescribe the medication during pregnancy or breastfeeding.
Contraindications
Among the contraindications:
- severe intolerance associated with a medicinal substance;
- liver pathologies;
- gout.
Side effects Tibinil p500
Main side effects:
- problems with digestion: nausea, diarrhea, vomiting and liver dysfunction;
- signs of allergy: itching, epidermal rash and arthralgia;
- Others: active gout or hyperuricemia. Photosensitivity is observed occasionally.
Interactions with other drugs
Pyrazinamide reduces plasma levels of cyclosporine.
The drug increases plasma uric acid levels and weakens the activity of anti-gout drugs (including sulfinpyrazone and allopurinol) when combined with them.
Storage conditions
Tibinil p500 should be stored in a place closed to small children and sunlight. The temperature is standard for medicinal substances.
Shelf life
Tibinil p500 can be used within a 3-year period from the moment of implementation of the therapeutic element.
Analogues
Analogues of the drug are the drugs Payzina, Phenazid with Teriz, as well as Inbutol and Pira.
Attention!
To simplify the perception of information, this instruction for use of the drug "Tibinil p500" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.