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Teofedrin
Last reviewed: 23.04.2024
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Teofedrin is a complex medication with antispasmodic and bronchodilating activity.
Indications Teofedrina
It is used for the treatment of obstructive bronchitis, having a chronic stage, and also for asthma. Also, the drug can be prescribed for pulmonary emphysema.
Release form
The release of the drug is implemented in tablets, in the amount of 10 pieces inside the pack.
Pharmacodynamics
Teofedrin helps to relax the smooth muscles of the bronchi. The influence of the drug leads to an increase in the bronchial lumen, the expansion of the pulmonary vessels, and besides, an increase in the strength of heart contractions and heart rate indicators, as well as an increase in cardiac blood circulation.
The drug has anti-inflammatory activity, and in addition it has m-anticholinergic and moderate diuretic effects. The caffeine contained in the medicine removes the feeling of drowsiness and fatigue, stimulates the work of psychomotor brain centers, potentiates the effect of painkillers and has analeptic effect.
An analgesic of non-narcotic nature, a substance paracetamol, blocks the activity of COX within the central nervous system, and with it affects the pain and thermoregulation centers.
Phenobarbital has an antispasmodic and muscle relaxant effect, and in addition it provides a mild and long-lasting sedative effect and corrects the psycho-emotional reactions of a patient with broncho-obstruction syndrome, which has a different nature.
Ephedrine hydrochloride stimulates the activity of bronchial adrenoreceptors, leading to their expansion, and also increases the excitability of the respiratory center. Citizin, which is an analeptic of the respiratory type, contributes to the reflex stimulation of the respiratory center - with the help of potentiated impulses from the carotid glomeruli.
Extract of belladonna vulgaris contains alkaloids from the category of atropines. This element has antispasmodic and analgesic properties.
Pharmacokinetics
Paracetamol is well absorbed inside the gastrointestinal tract after the use of drugs inside. Plasma Cmax values are noted after the 1st hour. The period of excretion of metabolic products of paracetamol is in the range of 1-4 hours. Basically this process is carried out by the kidneys. Half-life is 3 hours. This period can be prolonged in people with kidney or liver failure, as well as in connection with drug overdose.
Peak blood levels of theophylline are observed after 2.5 hours. Half-life is 11 hours.
After oral administration, atropine synthesizes 18% with blood protein. Approximately half of the portion used is excreted unchanged through the kidneys.
Ephedrine has good absorption inside the digestive system. Inside the plasma, the desired therapeutic values of the substance are maintained. Biotransformation of ephedrine occurs inside the liver. Excretion - mainly with urine.
Dosing and administration
An adult should use the 0.5-1st tablet 1 times a day. If required, the daily portion can be tripled. Allowed and the increase in 1 single dose of drugs (2 tablets, a maximum of 3 times per day).
Children from the age group of 2-5 years are required to take 0.25-0.5 tablets, and children at the age of 6-12 years old - 0.5-0.75 tablets.
The medication must be taken in the morning or in the afternoon. The duration of the therapeutic cycle is chosen by the physician.
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Use Teofedrina during pregnancy
It is forbidden to use Teofedrin during lactation or pregnancy.
Contraindications
Main contraindications:
- sleep disorders;
- atherosclerosis in the coronary and cerebral vessels;
- convulsive states;
- severe heart disease;
- glaucoma;
- thyrotoxicosis;
- liver disease;
- the presence of intolerance regarding the elements of the drug.
Side effects Teofedrina
When using Teofedrin, nausea, insomnia, epigastric pain, tremor, vomiting, tachycardia, and difficulty urinating can occur.
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Overdose
Poisoning with Teofedrin can lead to headaches, abnormal heart function, nystagmus, a feeling of weakness, and also convulsions, ataxia, hyperhidrosis, nervous agitation and a decrease in blood pressure values.
To eliminate overdose, you need to hold a gastric lavage. In addition, symptomatic procedures are performed along with constant monitoring of vital body functions (pulse, respiratory processes, blood pressure indicators).
Interactions with other drugs
Negative symptoms of Teofedrin are potentiated when it is combined with furosemide, indirect anticoagulants, antibiotics, cimetidine, and in addition with fluoroquinolones, MAOI, carbamazepine, β-adrenergic blockers and hormonal contraception.
Paracetamol contained in the drug can cause intoxication in the case of a combination of drugs with barbiturates or inducers of hepatic enzymes.
Ephedrine reduces the drug efficacy of analgesics and tranquilizers.
The bronchodilator effect of the drug is weakened in the case of a combination with β-blockers.
When combined with rifampicin, blood values of theophylline are reduced, and when combined with erythromycin, oleandomycin or ciprofloxacin - on the contrary, they increase.
The drug reduces the therapeutic activity of doxycycline, as well as its absorption.
The use of the drug together with lincomycin is prohibited.
It is necessary to abandon the combined use of drugs with psychotropic drugs and anticonvulsants.
The properties of oral contraception, antihypertensive drugs and antidepressants are weakened when combined with Teofedrin, while the effect of diuretics and hypnotics may increase.
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Storage conditions
Teofedrin must be kept in a dark place with temperature indicators within the limits of 15-25 ° C.
Shelf life
Teofedrin can be used within 24 months from the date of manufacture of the pharmaceutical agent.
Analogs
Analogues of the medication are such drugs as Trifedrin IP and Bronchophilin with T-Fedrin.
Reviews
Teofedrin, if we proceed from the reviews, is considered to be quite an effective drug. But many patients note that doctors are rather reluctant to write him out - because it is potent and its use creates a high risk of developing psychological dependence.
Attention!
To simplify the perception of information, this instruction for use of the drug "Teofedrin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.