The active component of Tarcev is well absorbed after oral administration. The limiting content in the serum is observed after four hours. Biological availability in a healthy person is estimated at 59%. The presence of food masses in the stomach can increase the bioavailability of the drug.
The limiting content in the serum is 1.995 ng / ml. Concentration equilibrium is observed after 7-8 days. Before using the subsequent dose of Tarcev, the minimum level of the active ingredient in the serum is 1.238 ng / ml.
In samples of cancer tissues after 9 days of treatment, the level of the active ingredient is found to average 1.158 ng / g. This is about 63% of the limit level in the serum in a state of equilibrium. After 60 minutes after taking Tarcev, the limiting content of the drug in the plasma can reach 73%. Binding to plasma proteins is 95%.
Metabolism of Tarceva occurs in the liver, with the involvement of enzymes in the process. Extrahepatic metabolic processes are observed in the intestinal cavity, in the lungs, directly in tumor tissues.
The average clearance is close to 4.47 l / h. The half-life is 36.2 hours. Metabolism products and unchanged drug residues are excreted mainly with calves (more than 90%), and to a lesser extent - through the kidneys.
The combined treatment of Tarceva and Gemcitabine has no effect on the clearance of the substance erlotinib in the serum.
, , , , ,